Conserved Protein Domain Family
GH101_N
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pfam17995: GH101_N 
Endo-alpha-N-acetylgalactosaminidase N-terminal
This is the N-terminal domain found in Streptococcus pneumoniae endo-alpha-N-acetylgalactosaminidase (EC:3.2.1.97), a cell surface-anchored glycoside hydrolase from family GH101 involved in the breakdown of mucin type O-linked glycans. This is a twisted beta-sandwich domain composed of two sheets of six and seven antiparallel beta-strands. The domain appears to be missing the extended metal and carbohydrate-binding loops.
Links
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Statistics
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PSSM-Id: 407838
Aligned: 6 rows
Threshold Bit Score: 279.373
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_005399044             114 WVPVElagVPKGTVEVVEEKGVRYNLLSSVDGQDNGSKLALFTKpEGWKTSDDGSATVKLTFVEKSADDQGRFGVFLHYG 193  He...
EGV04666                 411 WKTVDk-kEQQGTVAIREEKGVRYNQLASTAQNDNGKNPALFEK-EGLTVDANGNATVDLTFKEESETGKSRFGVFMKFK 488 
ESK65031                 125 WTATG---SRKGTVEVVEEGGVRYNKLASTAQNDNGQNPALFEK-KGLEVDQDGNASVNLTFKDLSTEKQSRFGVFLKYK 200 
EEW38171                 183 WDSSS---RVKGKVEVVEEGGVRYNKLTSTSSNDNGANEALFEK-QGLQADEEGNVNIDLTFKANTAPAETRFGVYLKYK 258 
PRJNA308559:AWM72_00235  140 WSLVS----GDGQKQVIEEQNTRYLRLSSNSTDSESS--SLYKK-DGMEVNEDGTANYTLNFIDRTEADSSKFGLFLSRD 212 
EEU12177                 126 WNKAS----KEGEVEETIVDNTRYNNLKSTQKNDNGQNTANFKK-EGVESNPSGNTNVNVDFIDNSNENQSRFGVFLYHK 200 

WP_005399044             194 DPNNNIFVGYDKEGWFWQVKSSKVSAgtgWYQGKRVSAPELDSKNELTISLKSDGQLNAYLDGNSLFDTKVIDGALFDAL 273  He...
EGV04666                 489 DTDNNVFVGYDQGGWFWEYKTNGSGL---WYQGGRVAAPVNGSENHLTISLKSDGQLNATNNDVKLFDTLTLPSAVNDKL 565 
ESK65031                 201 DPANHIFVGYDRDGWFWEYKSPKAST---WYQKGRVAAPKAGEVNNLSITYKKDGQLNATNNGKSLFDTLLVPEEVKAAL 277 
EEW38171                 259 DNDNNIFVGYDKGGWFWQYKGPGVNT---WYSKTRVEAPAIGEENHLSIVYKKDGQLNATNNGQNLFSTEVVPEAVKNAL 335 
PRJNA308559:AWM72_00235  213 QENNHLYLGYDTDGWFWSYKTPTVDN---KLTSHRSDAPIKGEQNQVLISLKSDGQLNATNNGENLFDTINLPGSVMDSL 289 
EEU12177                 201 DNSNNIFVGYDRAGWFWEYKLNGKGD---YYGGKRVEAPKKGEKNSLSISIKSDGQLNATNNGNAVFDTKVIPKEIFDAL 277 

WP_005399044             274 KDNKTIVLKATSWG-THRTKSMIETLNQ 300  Helcococcus kunzii
EGV04666                 566 KDEKKIVLKAGTYNsSERTIVNIKTDDQ 593 
ESK65031                 278 EGQNKIYLKAATWG-NERTTVAVQADDQ 304 
EEW38171                 336 AGIKKVYLKAGTWG-SELTSVSIKADNQ 362 
PRJNA308559:AWM72_00235  290 QAHPQAYLHLGSTP-EGPTVIDVKTDNQ 316 
EEU12177                 278 INNRSVLLKLGSYG-NETTNILVKTDNQ 304
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