Conserved Protein Domain Family
Crystall_4
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pfam17945: Crystall_4 
Beta/Gamma crystallin
This is the C-terminal domain found in mucin glycoproteins such as secreted protease of C1 esterase inhibitor from EHEC (StcE). This domain adopts a beta/gamma crystallin fold and has been shown to be dispensable for substrate binding. Furthermore, deletion analysis suggest that lack of the C-terminal resulted in impaired association with the cell surface.
Links
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Statistics
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PSSM-Id: 496861
Aligned: 9 rows
Threshold Bit Score: 169.51
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_040680899 387 GCITSLLSGARYCLPPGQRSGYSLPAWIYAHDVQVHAAPGTAVMLSDVENLAYHRFASFTGFVQNWELTKVRARNGKHVD 466 
2_pfamImport   1 GCIVSLDSAQKYCLPAGQQPVQQLPAWIKGQDVFVQADQGVAVRLSDRPNFAYNRVATFSGTVSHDKLIKVRADNGEDLD 80  
KGQ11607     291 GCIVNIDNDDKYCLQAGERSPYSLPSWIYNKQVYVDAAPGTAVVLSDWDNLSYNRLARFEGTVENDRLKAVKADNGETLD 370 
KGQ03577     291 ACIVSTQTNDRYCMSPGDKAEYALPEWIRGHTVRVDAGPGTAVELCDMDNLSYNRVAKFVGSVDNSTLKAVKANNGETLD 370 
1_pfamImport   1 GCIVSLRTSARYCLSADQEAEYSLPPWIYEHDVYVDAAPGTAVQLSDFDNLSYHRIATFVGTVDNGRLKSVRAANGVLLD 80  
Q1LIQ7       382 GCIVSLVSVDKYCLPAGERSAYSLPAWIYAHDVVVQADAGIGVMLSDWDNLSYNRLAVFSDVVENENMKRVQAYDGQTLD 461  Cupriavidus me...
Q9KTH2       126 ACIVSRQTGERFCLKEGERSGYSLPAYIYGHEVDVEAPLGLGVMLSDWDNLSYNRLAVFGGNTQNEQMRAVKAYNGETLD 205  Vibrio cholerae
3_pfamImport   1 ACIVSRDTGAKYCLQAGQRSGYSLPSYIRGHDVDVIAPEGLGVMLSDWDNLSYNRLAVFERHTHNEAMEHVLARNGQYLD 80  
4_pfamImport   1 ACIVSRQTGAEYCLKAGQRSGYSLPYYIRGHQVDVIAPEGLAVMLSDWDNLSYNRLAVFTKDTNNEDMKNVRAYNGRYLD 80  

XP_040680899 467 FSRPRSMRVI 476 
2_pfamImport  81 FSRPVSMEVI 90  
KGQ11607     371 FSHPKSMRVV 380 
KGQ03577     371 FSRPHSMRVL 380 
1_pfamImport  81 FSRPHSMRVV 90  
Q1LIQ7       462 FSKPRSMRVV 471  Cupriavidus metallidurans CH34
Q9KTH2       206 FSKPRSMRVV 215  Vibrio cholerae
3_pfamImport  81 FSNPRSMRVV 90  
4_pfamImport  81 FSHPRSMRVL 90
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