Conserved Protein Domain Family
LID

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pfam17916: LID (This model is not part of the current CDD release)
LIM interaction domain (LID)
LIM-homeodomain (LIM-HD) proteins are transcription factors that are critical in the development of many cell types and tissues. The activity of LIM-HD proteins is dependent on the essential cofactor LIM domain-binding protein 1 (Ldb1). This entry represents a 30-residue LIM interaction domain (LID) that binds to the LIM domains of all LIM-HD and closely related LIM-only (LMO) proteins. Isl1 (Insulin gene enhancer protein 1) and Isl2 each contain a LID-like sequence in their C-terminal regions, the Lhx3-binding domain (LBD), which binds the LIM domains Lhx3 and Lhx4.
Statistics
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PSSM-Id: 523019
Aligned: 2 rows
Threshold Bit Score: 58.5923
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_045096226 468 DVMVVGEPSMMGSDFGEGDERTISRVENT 496
NP_509845    364 DVMVVGEPSMMGSEFGENDERTISRVENS 392 Caenorhabditis elegans
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