Conserved Protein Domain Family
Ski2_N

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pfam17911: Ski2_N (This model is not part of the current CDD release)
Ski2 N-terminal region
This region is the N-terminal extended region found in the Ski2 protein. The Ski complex is a conserved multiprotein assembly required for the cytoplasmic functions of the exosome, including RNA turnover, surveillance, and interference. Ski2, Ski3, and Ski8 assemble in a tetramer with 1:1:2 stoichiometry.
Statistics
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PSSM-Id: 523017
Aligned: 32 rows
Threshold Bit Score: 108.15
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6CWL5         62 DLLQsmpdmntsneikpnAVKNNNTVYSSFLHCPDPV--SRTSYHFHRLGIDGKITSYEEKvNIEDVVNANSANSLSLTR 139  Kluyveromyces...
XP_032521182   42 ERSQ--------------THWHRKSDIDSLFKSDDEElgIDTTLEVVRDPRTGEIIGLEEI--NIP--VQDDEDNLSMSR 103 
XP_008195520   37 ETNQ--------------EFWPRTPDLKELLFFEESP--LCTTLKVQRDPNTGEIIEFREI--PIQSAGANATNSMSLTR 98  
XP_046447350   35 EMVQ--------------QYWKHDANMKQLCQTEVAA--TPTTLLVERDINTGALAEVVEI--VTPHAGMTNKTSMSLQR 96  
KOX77059       41 DNAQ--------------CYWPRKLDILSFLNCDIAP--LGTTLKFDRDPVTGKLGEMHEV--PLKSAGETARNSMSMTR 102 
KPP75355      115 DSAFqk----------flRVVQRKRQVESLLHCAVSP--MHSGLSVVRDPTTGMLLDFNEV--LLEDTGLSSKNSLSLLR 180 
XP_009056510   70 NRAQ--------------RCWSRDKKAERLYSVDVCP--VQTTIQVDRNPTTGQLIGFKES--GIKDIGKLANNSLSLHR 131 
KOF76953       64 KKHQ--------------KYWPRTKHSENLLEMDVTP--VQTTITVERNPTTGKLLGYQEE--LLTNTMSTIKNSMSFKR 125 
KXN66079       41 SKYQrvv---------piKEAPRIHDLTLGLDVQELN--TKLDLEFERDTITNKVINFKQH---VK-SLDTSSTDQSFQR 105 
2_pfamImport    1 EKTQ--------------QRWDLQVDKSLLFEIDPPD--IGTQTLFYRGGRNFRIVNYEEVpAPKEA-NGD---AQAVAP 60  
Q6CWL5        140 KINHQGDLIRGTTNQLPFTPGGLG---Q-DVvetts--eslqiNAESAGKLLPR-D-------KFGLFNVPPGLERGIVP 205  Kluyveromyces...
XP_032521182  104 APLPPNLATRGTTTQNPFLPAGFE---E-ELqkml-----deaAQSSEIEINFE-DdepgkflGEDILSTAPGSKEAVLF 173 
XP_008195520   99 QPAPPSEATRGNASFIPFWPASFP---D-PVsq---------lPKQELL--------------DTELLTVPPGFTRGIVF 151 
XP_046447350   97 IPGPPSEWVRGSASNVPFWPGGLEwnpS-ETmsd-------llQMDELLEE-LC-F-------KKDLKTVPPGFKNGMNF 159 
KOX77059      103 APGPSSDNIRGNTSNIPFWPGGFD---E-PEivi-------dssVE-----EID-F-------ENNLRTLAKGFSAGVEF 158 
KPP75355      181 PPGPPSESLRGSNTNYPFLPGGME---E-LTleq--------ikKKSEQEEEID-F-------ENGLLTVAPGLKAGMDF 240 
XP_009056510  132 TPGNNYDDIRGSTTNYPFWPGGMD---E-PIidn-------inQTD--SQLGLN-L-------STELLSTAPNMPAGMVF 190 
KOF76953      126 PPGPPTQDVRGCATNYPFWPGGMD---KiPSyk---------gLIAKGKYDVID-F-------EKNLLYNAPGLKAGMDY 185 
KXN66079      106 PLGK--NYVRGSSNQMPFLPGGIDqqdD-QNmkdllqqrknwlNFDEFVDNLKS-S-------DPQSTIVLEGFDRGLYL 174 
2_pfamImport   61 SNLTAGLALAGRGHGIEDAAAEAE---E-EWlqrsilarenakSDASGLQRVIQaG-------TGGLLEVAPGLQRGIRF 129 
Q6CWL5        206 RVEAGSNDDE 215  Kluyveromyces lactis
XP_032521182  174 AEDGMTLLDH 183 
XP_008195520  152 ASDGRTVLSK 161 
XP_046447350  160 GSSDVNLNLA 169 
KOX77059      159 KSDNCTPKER 168 
KPP75355      241 AAKEPRTSRG 250 
XP_009056510  191 KEKEESIDNF 200 
KOF76953      186 DGEVPKEIPA 195 
KXN66079      175 PETGSGQADI 184 
2_pfamImport  130 MGDRPKPKPK 139 
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