4OVA


Conserved Protein Domain Family
KH_9
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pfam17904: KH_9 (This model is not part of the current CDD release)
FMRP KH0 domain
This entry corresponds to the KH0 domain from the FMRP protein. This is a divergent KH domain that was discovered through solving the structure of an N-terminal fragment of the FMRP protein. KH0 does not have the canonical G-X-X-G motif between helices A and B. It has been suggested that this domain may be involved in RNA binding.
Links
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Statistics
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PSSM-Id: 523012
Aligned: 6 rows
Threshold Bit Score: 120.272
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4OVA_A       123 KDTFHKIKLDVPEDLRQMC---------AKEAAHKDFKKAVGAFSVTYDPENYQLVIL-----SI--------------- 173 human
1_pfamImport   1 KNTFHKIEIEVPEDLREFA---------KMENAHKEFQKAIGAAVCRYVPERGVLLAI-----SR--------------- 51 
EEC03181     132 KSTFTKFELEVPEDLREYQ---------QRLGFCAQLQRNRGDGGLATSDG-SILFLLffwlqAR--------------- 186
KYO32817     123 KDTFHKIKLEVPEDLRQMC---------AKESAHKDFKKAVGAFSVTYDSENHQLIIL-----SI--------------- 173
KPP64538     149 KSTFYRCTVAVPEDLKAACvhslivdgsCSRSARRDFARN--ACSFTSGAKMNSCTKT-----SRkrwrpvgsstamnrg 221
XP_014769063 124 KDSFRKAILDVPSDLREVC---------REESTLAEFKKHCGAAVVIYNSDDNALVVV-----ST--------------- 174

4OVA_A       174 -----NEVTSKRAHMLIDMHFRSLRTKLSLIMRNEEASK 207 human
1_pfamImport  52 -----HENLHRHSTMLQEMHFRNLSQKVLLLKRTEEAAR 85 
EEC03181     187 -----SEAAKKRAEMMSEIYYRNLRQKLILLSKTEEAAR 220
KYO32817     174 -----NDVTTKRANMLIDMHFRSLRTKLSLILRNEEASK 207
KPP64538     222 assywKESTMKRVSILSDMHLRNIRTKLMLMSRNEEATK 260
XP_014769063 175 -----NFSVIKKASLMGDMFLRNLRQKVLLKQRTEEAVK 208
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