8FVU,7RAV,5AJ2


Conserved Protein Domain Family
NLRC4_HD
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pfam17889: NLRC4_HD (This model is not part of the current CDD release)
NLRC4 helical domain
This is a helical domain found in NLRC4 , Nucleotide-binding and oligomerization domain-like receptor (NLR) proteins. Structural and functional studies indicate that the helical domain HD2 repressively contacted a conserved and functionally important alpha-helix of the NBD (nucleotide binding domain). Furthermore, the HD2 domain was shown to cap the N-terminal side of the LRR (leucine-rich repeat) domain via extensive interactions. Other family members carrying this domain include baculoviral IAP repeat-containing protein 1 (Birc1) also known as neuronal apoptosis inhibitory protein (Naip).
Links
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Statistics
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PSSM-Id: 523005
Aligned: 25 rows
Threshold Bit Score: 108.134
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8FVU_A        772 EHQDLGLYHLKQINSPMMTVSAYNNFLNYvSSLPSTKAGPKIVSHLLHLVDNkESLENIS---------ENDDYLKHQPE 842  human
7_pfamImport    1 EEVAKGNAYLQKMVCISDITSLYSNLLLY-TCGSSAAATRAVLRHLTGVCQH-GSLDGLSvtrrplwrqASIQSMNNTTD 78  
XP_015219364  765 AEREKSQNDLKRIDSVAKFVY-FKLFLLF-TCTMSQTAATVIVDFVLNKLNRnTDS-------------RADEVINKYPE 829 
F1M649        465 EEVSKGNSYLKKMVSISDITSLYGNLLLY-TCGSSTEATRAIMRHLAMVCEH-GSLQGLSvtkrplwrqESIQNLRNTTE 542  Norway rat
XP_003908534  465 EEVTKGNGYLQKMVSISDITSTYSSLLRY-TCGSSVEATRAVMKHLAAVYQH-GCLLGLSitkrplwrqESLQSVKNTTE 542 
XP_023475038  494 EEVTKGNSHLQKMAFISDITSKYSNLLLY-TCGSSAEATRTVLRHLAAVCQH-GSLHGLSitkrplwrqESKENVKNTTV 571 
4_pfamImport    1 EDVDRGLQYLQQINTFVKISGRYQYILRY-ACVEASKAVPQIVTHLLSLPSCeKSFESQI---------KNDLYLQQTPE 70  
KFR06549      535 EKLERGLQYLQQINTFRKVAGRYNFLLAY-TCSFSSKAVPQIISYLFKLIDCkESLESQS---------EDDEHLQHHSD 604 
6_pfamImport    1 EDQDLGLYYLKQINSPMLAVSSYYNFLKYvCSYSSTKVGPNIVSHLLHLADSkESLEYLP---------RNGDSLKHEEE 71  
5AJ2_B        110 EEVSKGNSYLNKMVSISDITSLYGNLLLY-TCGSSTEATRAVMRHLAMVYQH-GSLQGLSvtkrplwrqESIQSLRNTTE 187  house mouse

8FVU_A        843 ISLQMQ-LLRGLWQICPQaYFSMVSEHLLVLALKTAY 878  human
7_pfamImport   79 QEILKAiNINSFAECGINlFQESVSKSTLSHEFETFF 115 
XP_015219364  830 TTDMNNhIIQFLYEF-PEcRDSSVDTYLLNEVLDVLY 865 
F1M649        543 QDVLKAiNVNSFVECGINlFSESISKSELSQEFEAFF 579  Norway rat
XP_003908534  543 QEILKAiNINSFVECGIHlYHESTSKSALSQEFEAFF 579 
XP_023475038  572 QETLKAiNINSFTECGINlFHESRFESALSEEFEAFF 608 
4_pfamImport   71 LKLRQQeLLSVTLTLFPEvYLSTFSDFVLELVTELAY 107 
KFR06549      605 LPIRML-FIDQLSSINPKlLLPVFMQYLLGFATSVAY 640 
6_pfamImport   72 MPLDTQ-AIRLLWQLCPEqCFLLLSEFLLDFALMIAY 107 
5AJ2_B        188 QDVLKAiNVNSFVECGINlFSESMSKSDLSQEFEAFF 224  house mouse
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