4PO6,5L04


Conserved Protein Domain Family
Jak1_Phl
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pfam17887: Jak1_Phl (This model is not part of the current CDD release)
Jak1 pleckstrin homology-like domain
This entry is for the pleckstrin homology-like (PHL) subdomain found in Jak1 proteins. JAK1 is a member of the Janus kinase (JAK) family of non-receptor tyrosine kinases that are activated in response to cytokines and interferons. PHL (residues 283-419) together with the N-terminal ubiquitin-like subdomain (residues 36-111) and an acyl-coenzyme A binding protein-like subdomain (residues 148-282), associate into a canonical tri-lobed FERM domain.
Links
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Statistics
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PSSM-Id: 523003
Aligned: 17 rows
Threshold Bit Score: 198.324
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4PO6_A        265 QAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEvnkeegssgSS-GRNPQASLFGKKAKAH-KAV 342  human
2_pfamImport    1 QAEGKLCYIQDHGQATLDPGKESALGPPTHEVLVTGTGGIQWRPVQAEgsg---gsgSG-SRNPQANLSGKKAQAQ-EVD 75  
XP_006928454  286 QAVGDPCYVQDGGQSPPEPGPELAPGPPTHEVLVTGTGGIRWRPVQAEgpg----gdGC-SRNPCAGPSGKKSKAQ-EVG 359 
XP_008107519  284 ELFETTSLLISSENEKS-FNMDDCNIIPHYEVIVTGNQGIQWRVKPyg-------smLQvTQTEKEKHKTKRKKSDgKVK 355 
XP_002931642  270 ESFETNSLIIKSENEQNGFNISDYDSMRRYEVLVTGNSGIQWRRKPTC-------------TTSEKDRKLKRKKTEsKSK 336 
4_pfamImport    1 EIFETSFLLISAENEVNKFNCGDNE---RYEVMVSGNNGIQWRLKP----------------SPVPTEKEKKKKSDsKSK 61  
XP_027319589  284 EIFETSSLLISSENEINRFNCGDNEILPLYEVIVTGNNGIQWRLKP----------------NSVQTEKEKKKKSDgKTK 347 
XP_018608948  280 EVYETSMLQFTSENEKSHVTAFHENDPPVFEVQVSGNNGISWRKKPDP---------T--LPFPKDKNKSKKNKVY---- 344 
5_pfamImport    1 QAEGEPCYIQDSRRASADHNLEPALGSPTHEVLVTGTGGIQWRPVQVEvss---dvnDS-SRNSQTHLSGKKAKAR-EAG 75  
NP_001107236  286 QADGEPCYIREGGQAPPDPGSESAAGPPTHEVLVSGTEGIRWRLVPAEgpad-ggagGG-SRMPDADPSGKKMKAE-EVG 362 

4PO6_A        343 GQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSH 412  human
2_pfamImport   76 LQPASRPKGLPWASFCDFQDISHLVVKEHHVSVYCQDNKCLELTLPSRATALSFVSLVDGYFRLTVDSSH 145 
XP_006928454  360 NQPVDRPQEAPWAYFCDFQDITHVVLKERHVSIHCQD-KCLELTLPSRAVALSLVSLVDGYFRLTADSSH 428 
XP_008107519  356 KNEEKSKRED-WNNFSYFPEITHLVIKESTVSVYKQDNKRMELKLSSHGEALSFAALVDGYFRLTTDAHH 424 
XP_002931642  337 NSDEKGKLKDEWNCFSYYPEITHIAIKEDTVIINNQDNKSMELKLSSQEEALSFAALIDGYFRLTADAHH 406 
4_pfamImport   62 KVEEKHKLREAWNSFSYFPEITHIVIRDCAVSVNKQDNKRMELRLGSHAEALSFTSLVDGYFRLTADAHH 131 
XP_027319589  348 KEEEKHKIRDLWNNFSYFPEITHIVIKESTVSINKQDNKRMELKLSSHDEALSFASLIDGYFRLTADAHH 417 
XP_018608948  345 GKNKNEKKKDSWILFSDFHEIIHVAIRDSTVTINKQD-KKMEMQLAFPAEALSFAALVDGYFRLTVDAHH 413 
5_pfamImport   76 GQPANRPREPPWTYFCDFQDITHLVLKGCRVTIYQQDNKCLELRLPSRAAALSFVALVDGYFRLTADSSH 145 
NP_001107236  363 SEPVDRPRESPWSYFCDFQDITHMVLKERHVSIHCQDNKCLELTLPSRAAALSLVSLVDGYFRLTADSNH 432
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