CDD Conserved Protein Domain Family: Insulin

pfam17870: Insulin_TMD (This model is not part of the current CDD release)

Insulin receptor trans-membrane segment

This entry represents the trans-membrane domain (TMD) found in insulin receptor proteins. The TMD of the insulin receptor is within the beta-subunit and contains 23 amino acids. Mutations in the TMD were shown to have effects on receptor biosynthetic processing and kinase activation. Substitution of the entire TMD of the insulin receptor (IR) resulted in constitutive kinase activation in vitro, while replacing the TMD with that of glycophorin A inhibited insulin action. Structural studies show that TMD contains a helix and a kink when it is purified in dodecylphosphocholine (DPC) micelles. The residues 942-948 preceding the TMD have a propensity to be a short helix and may interact with membrane.

7PG0_A 928 TYFYVTDyLDvPsNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGP 975 human 3_pfamImport 1 THFFVPN-PD-P-GLVWIVMGPIICFILLLFVGVGVFVVFKKKQTEGP 45 XP_040040008 721 TYFYMPN-SD-P-GLIWIVMGPVICFILLLFIGGGVFVILKKRQTEGP 765 KPP59640 708 TYFYVPDrTD-R-NLMKIVIGPVVCLILLLLVGAGVFVMFKKKQIEGP 753 5_pfamImport 1 TYFYVQDpRD-PsSVMKIAIGSVICIVLILVVAGAVFMVVRKKQTEGP 47 4_pfamImport 1 TYFYMADyLN-PqSNLAVVIVPVVFSIIIAGIIGATYVFVKKRQTEGP 47 XP_023196058 922 TYFFMPS-PD-T-GIALIVSAPIVSSILLLFVGVIAFYVFKKRQTEGP 966 XP_028906071 947 TYFYVADyYV-PsNIAKIIIGPVIFAIFVVGMIGAIYVFVKKRQTEGP 993 platypus

7PG0

Conserved Protein Domain FamilyInsulin_TMD

Conserved Protein Domain Family
Insulin_TMD