Conserved Protein Domain Family
SCP_3
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pfam17844: SCP_3 
Bacterial SCP ortholog
This domain is found in MSMEG_5817 gene product from M. smegmatis. It has been shown to be vital for mycobacterial survival within host macrophages. Crystal structure revealed a Rossmann-like fold alpha/beta two-layer sandwich forming a highly hydrophobic interface cavity and with high structural homology to the SCP family. Hence, it has been suggested that this domain may be involved in the interaction of apolar ligands through its hydrophobic cavity. Alanine-scanning mutagenesis of the hydrophobic cavity of MSMEG_5817 protein demonstrated that the conserved Val82 residue plays an important role in ligand binding.
Links
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Statistics
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PSSM-Id: 496780
Aligned: 85 rows
Threshold Bit Score: 123.399
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_022861508  34 DRSTVAMAVRYSLRLLEMKAPGGAVEVRVAPWGAVKILDGPRSDPHnlTPPDVIELDPTTWLRLASGMTRWDDERRRGAI 113 Bifidobacterium...
WP_056863347  31 DRADLRLLVKHFLAVLEQRAPGHSVEVRVPPYAAVQVIPGVRHTRG--TPPAVVETDALTWIALASGALTWGEADAAGRV 108 Nocardioides sp...
WP_012918271  16 ERADLKLLVKQLLKLLVAKAPGHAVEVRVPPYGAVQCIEGPRHTRG--TPGAVVELPAELWIDLALGRTTWAEARSTGKV 93  Kribbella flavida
WP_033518640  41 DRRAMAMAVRYTLAMMEIKAPGPGVELRVAPFGAVKILEGPASDPHnlTPPDVIELEPDVWLRLACGITDWGQEWHAGHI 120 Bifidobacterium...
WP_021617297  44 DRRGMAMAVRYSLYMLELRAPGPGVEVRVAPFAAVKILEGPQSDPHnlTPPDVIELDPAVWLRLVCGITSWSEEKNAGRI 123 Alloscardovia o...
WP_033497697  39 PRKDYAMAVRYSLYLLTLRAPGGAVEVRVAPWGAVKILDGPSSDPHnlTPPDTIELDPDVWLRVACGITSWSSERDSGHI 118 Bifidobacterium...
WP_394962320  41 PRKDYAMAVRYSLFLMEKLAPGPGVELRIAPYAAVKILEGPKSDPHnlTPPDVIELEPAVWLRMACGFTTWQEEKDAGHI 120 Scardovia wiggsiae
WP_022860198  41 DRRTMAMAVRFSLFVLERKAPGPGVEVRVAPFSAVKILDGPASDPHnlTPPDVIELDPPVWLRLATGITTWDEEREAGHI 120 Bifidobacterium...
WP_034247112  27 DRADVRTAVRFTLEELAARAPGGAVEIRVPPDGAVQAVPGPGHTRG--TPPNVVETDPRTWLELITGRTAWVDAVRDGRV 104 Actinotalea fer...
WP_015750129  28 DRDRVAAAVRASLRWLAQAHPGKAVEIRVPPYAAVQAMGGLSHTRG--TPPNVIETDPATWLALVVGTVSWADALGDGRV 105 Nakamurella mul...

WP_022861508 114 AAMGERDDLSALLPL 128 Bifidobacterium minimum
WP_056863347 109 SASGQRADLAPHLPL 123 Nocardioides sp. Leaf285
WP_012918271  94 RASGERTDLSGLLPL 108 Kribbella flavida
WP_033518640 121 SAVGERDDLSMLLPL 135 Bifidobacterium cuniculi
WP_021617297 124 SAVGERDDLSGLLPL 138 Alloscardovia omnicolens
WP_033497697 119 SAMGERDDLSRLLPL 133 Bifidobacterium psychraerophilum
WP_394962320 121 SAVGVRDDLSRFLPL 135 Scardovia wiggsiae
WP_022860198 121 SAVGERDNLSALLPL 135 Bifidobacterium magnum
WP_034247112 105 SASGLRADLGPALPL 119 Actinotalea fermentans
WP_015750129 106 SASGTRADLSALLPL 120 Nakamurella multipartita
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