Conserved Protein Domain Family
dsRBD2
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pfam17842: dsRBD2 
Double-stranded RNA binding domain 2
This domain is found in HEN1 proteins from Arabidopsis. Structural characterization reveal that small RNA substrate bind to two double-stranded RNA (dsRNA)-specific binding domains, dsRBD1 and dsRBD2. This entry relates to dsRBD2 which together with dsRBD1 forms a strong grip on the duplex region of the small RNA substrate, and these interactions help position the other duplex terminus towards the MTase domain pfam13847.
Links
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Statistics
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PSSM-Id: 496778
Aligned: 24 rows
Threshold Bit Score: 204.877
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ESQ55292     333 PNGIYKLSRKALIAAQLPLRFTTKSSWRGPLPREILCMFCRQQELAEPVFTISTAPVKSMSDLLRSYKKLKDSESDNNSN 412 
XP_004955533 353 PDGNCKMSRDAILAAELPSVYS-RFSWKGLSPRDLLCSFCRNQRLSEPLFAVS----RVSCDMLTSAVSSEERGAPAKSV 427 
2_pfamImport   1 PDGNYKMSRDSILVAELPSGYS-RSSWKGLSPRYLLCSFCRLQRLAEPYFNVST--ASASCKVLGSAVSSEGMEVLKNAE 77  
XP_006413840 353 PNGIYKISREALLAAQLPVSFTTKSSWRGPLPREILCMFCHQHRLADPVFSVSADPVKSLSDIYRSHKKLKFSGSDD--- 429 
XP_013586520 336 PNGICKISRKALIAAQLPLLFTRESNWRGPFPREILCMFCHQQQLAEPVFTTSTAPAKSMSDLLSSFNKIKDD------- 408 
5_pfamImport   1 PNGIYKFSRQALIAATLPFSFTTKSSWRGPLPKEMLSIFCRQQQLAEPVFTISTSPVKPLSETLRSLKKLKDSESNDSNN 80  
XP_006283197 344 PNGIYKFSRQVLIAAQLPFSYTTKSNWRGPFPREILSMFCRQQHLAEPIFTITTAPVKPLDGILRSYQKLKDSERED--- 420 
NP_193824    335 PNGIYKLSREAIIAAQLPFSFTTKSTWRGPFPREILCMFCRQQQLVEPIFTISTAPVKPMSCILRSYQKLKDSECDEKDS 414 
3_pfamImport   1 PDGLFKLSREALFVADLPRLFTTKTNWRGSLPRDLLCAFCRQHRLSEPVFNVVC---NSDQDLPGPCKSLANEKSIMGFT 77  
XP_012830195 350 PGGAYKISRDAILAANLPSAFTMKSNWRGSFPRDILSTFCRFHYLSEPVFSTQSNSSEASLDLPGSRKKLKVTQSNKEE- 428 

ESQ55292     413 QYmswetedsdcddtNNHHYKRREKEEEPGSGTGYRCEVKILSKS-QDLVLDCSPGSFYEKENRAIQNASLKALSWFSSL 491 
XP_004955533 428 ---------------ENQFNDVRTDKENSD---SFKCEVKICSRK-QEILLEYSASDTWSKESDAIQNSALKVLIWFNNY 488 
2_pfamImport  78 ---------------NQYGGDGSNGKENPD---MFKCEVKIYSKM-QKLLLEYSTANIWSKESDAIHNSSLKVLIWFHSY 138 
XP_006413840 430 ---------------DDDENLNREKEDAPGLVHGYRCEVKILTKS-QDLVLECSPRKFYEKENDAIQNASLKALLWFSKF 493 
XP_013586520 409 ---------------SDNQYLSRGNWEMPGSGKGYRCEVKIFSKS-QDLVLDCSLKKLYEKENDAIQNAALKALSWFSMF 472 
5_pfamImport  81 QCvneya----gsddSFNHYNSKDEEELPVLESGYKCGVKILSKSlQDLVLDCSPRNFYEKESYAIQNAALKALTWFGSL 156 
XP_006283197 421 --------------------MRRKKLRIPRSGTGYRCEVKILSKS-QDLVLDCSPGDFYEKENHAIQNASLKALSWFNKL 479 
NP_193824    415 ECdekds----ecddSEYQYTSKGKEEIPESGTGYRCEVKILSKS-QDLVLDCSSRKFYEKENHAIQNASLNALSWLSRL 489 
3_pfamImport  78 S--------------KPGGDVATFIPNQNE-VQSFSCEIKVFSKN-RNLILESSPVDNFMKQGDAVQNASLKVLSFLNLY 141 
XP_012830195 429 ------------------------------KTEAFCCEVKIYSKN-QELIVQCSPQETHRKQTDAVQIAALKVLSWLNLF 477 

ESQ55292     492 F 492 
XP_004955533 489 F 489 
2_pfamImport 139 F 139 
XP_006413840 494 F 494 
XP_013586520 473 F 473 
5_pfamImport 157 F 157 
XP_006283197 480 F 480 
NP_193824    490 F 490 
3_pfamImport 142 F 142 
XP_012830195 478 F 478
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