Conserved Protein Domain Family
Bep_C_terminal
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pfam17841: Bep_C_terminal 
BID domain of Bartonella effector protein (Bep)
This entry is the BID (Bep intracellular delivery) domain located at the C-terminal of Bartonella effector proteins (Beps). It functions as a secretion signal in a subfamily of protein substrates of bacterial type IV secretion (T4S) systems. It mediates transfer of (1) relaxases and the attached DNA during bacterial conjugation, and (2) numerous Beps during protein transfer into host cells infected by pathogenic Bartonella species. Crystal structure of several representative BID domains show a conserved fold characterized by a compact, antiparallel four-helix bundle topped with a hook.
Links
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Statistics
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PSSM-Id: 496777
Aligned: 12 rows
Threshold Bit Score: 69.3613
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_062553622  862 KLASDPALKKQWEEVSMRFHHVYAQPEAAFKAANVDAMLsDPATAEKMLSritaePEAFGSLKGKTSVFAs-RADKADRD 940  Rhizobium sp....
2_pfamImport    1 KLDASARLEKKRGEIERLARLVYGDTAVASLTRQIGSAS-EGALAAEDVR-----NGKLGPLAGESGSWF--RAESFARQ 72  
1_pfamImport    1 RLTADPGLKKQWQEVTTRFTQVFAEPETAFKAVNVDAMLkDPARAQTTLAkiaaePEKFGALKGKTGIFAg-ANEKAARD 79  
WP_056320195  858 KLAADPALKKQWEEVSMRFHHVYAQPESAFKTVDVDAMLrDQAIAARTITriasePETFGALKGKTGLLAs-RSDRVDRD 936  unclassified ...
WP_046135188  858 KLSTDPALSKQWDDLSTRLRLVYADPEAAFRAMRFEALLaDPSVATERLGqldrePQSFGALRGRDGVFAa-KRDREDRR 936  Devosia limi
EJN05987      867 KLLADPAVKKQWEEVSIRFRYVFADPETAFRAMDFNAVLtDRQAARETLDrlvaaPASLGPLSGKTGMLAs-RSDRQARR 945 
WP_062557456  855 KLGNDPALKQQWDEVSTRFRYVFADPETAFRAMNFDAVLtDRQTANQVLHrlvdnPGTIGALNGKTGLLAg-RSEKEARR 933  Rhizobium sp....
vbi:Avi_9189  878 KLGADPTLKQQWEEVSVRFRYVFADPETAFRAINFDTVLaDKEAAKAVLQkleaePASIGALKGKTGILAs-KTEREARR 956 
4_pfamImport    1 KLDTDPALKKQWEEVSTRFVYVYADPETAFRAMNFDAVLaDKDSARQVLQtleaePAFIGPLKGKTGILAs-KADREDRR 79  
WP_013913803  858 KIVADPACRKQWQDMSARFALVFSNPEVAFKAMNFDAVLhNPAMRKATLNrlakePESFGDLRGAKGILTg-QAAARERH 936  Afipia carbox...
3_pfamImport    1 RITDIPRYRQERSVLADSAAKVWRDPAAALAMI--EDLLrKGAMPERLARavandPSAYGALRGSGRILDrlNASGRERR 78  
Q1QF79        863 RILADPAIKKQWKEVSTRFRLVFADPERAFRAVNFDAMLkDSAAAVSTIQqlaanPESFGALRGKTGLLAg-KADKQERQ 941  Nitrobacter h...

WP_062553622  941 RALKNVTPLADSIRDYLR 958  Rhizobium sp. Root149
2_pfamImport   73 TAKAHAPHLAAALADYGQ 90  
1_pfamImport   80 TALVNAPALARNLERYVT 97  
WP_056320195  937 RALKNVTPLADSISDYLR 954  unclassified Rhizobium
WP_046135188  937 VAEVNISALRRDIERYLK 954  Devosia limi
EJN05987      946 IAEVNVPALKRGIERYVD 963 
WP_062557456  934 VAEVNLPALKRDIEHYLT 951  Rhizobium sp. Root149
vbi:Avi_9189  957 VAEVNVPALKRDLEQYLR 974 
4_pfamImport   80 VAELNVPVLKRDLEHYLR 97  
WP_013913803  937 EAETNVAALSRDIERYAR 954  Afipia carboxidovorans
3_pfamImport   79 AAIVTVETTVDRIRSLGH 96  
Q1QF79        942 RAEANVPALKSDIERYLR 959  Nitrobacter hamburgensis X14
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