4UX8


Conserved Protein Domain Family
RET_CLD4
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pfam17813: RET_CLD4 (This model is not part of the current CDD release)
RET Cadherin like domain 4
RET is a single transmembrane-spanning receptor tyrosine kinase (RTK) that plays critical roles in the development of vertebrates. Structural analysis indicate that the ligand-binding RET ectodomain (RET-ECD) contains four consecutive cadherin-like domains (CLD1-CLD4) followed by a membrane-proximal cysteine-rich domain (CRD). This entry relates to CLD4 which is required for CRD folding.
Links
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Statistics
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PSSM-Id: 522962
Aligned: 21 rows
Threshold Bit Score: 167.507
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4UX8_A        376 LPS-TYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGAN-------CS-TLGVVTSAEDTSGILFVNDTKALR 446  human
XP_031812239  394 FPNiSYSFSVNRNAHRYAQIGKVCIENCKEFHGVNITYKLQSLSVN-------CT-ALGIITTPESTTGNLFVNDTSMLQ 465 
XP_007478546  394 FPNnTYYFSVNRNAHRYAQIGKVCIENCKEFHGVNVTYRLQSPSTN-------CT-ALGIITTPESTTGTLFVNDSSVLQ 465 
XP_069045218  393 FTNvSFLFTVDRKAAPYTQIGTVCVDNCKKFQGIEVTYKLNI-DRNasllvktCYaAVAIEQSREDSSAILYVNRTDSLR 471 
4_pfamImport    1 FANvTHMFPLARRASFYAQVGRVCVENCHRFDGFRVTYRLQVPDKNasadvqsCYaAISITQAPDDMWGLLYVNDSEVLC 80  
XP_004077559  394 FANtTQEFTVSRRASVYAQVGRICVENCLEFGGFRVTYWLEVLDKNasasslsCHaAISITQAPDGMWGLLYVNDSEPLH 473 
XP_023183794  395 FANiTHVFTLSRKASIYAQVGRICVENCLEFDGFSVSYQLEVPDKNmssellsCYsAISITQAPDRMLGLLYVNNSGALS 474 
XP_015462110  394 FSNiTY-VSLSRKSTLYSQIGKVCVDNCLKFKGIDIAYEIEIADRNvsadvlsCYsAVSVARSLEEMSGVLYVNDTKPFQ 472 
KPP59675      352 FPSaTSLFTVSRQSTAFAQIGRVCVDNCLKFHGISVVYRLVPAEKNssalersCYtAVGITPSSSDISAVLYIIHTEPLQ 431 
G3V9H8        405 LPM-AYSFPVNRRARRYAQIGKVCVENCQEFSGVSIQYKLQPSSTN-------CS-ALGVVTSTEDTSGTLYVNDTEALR 475  Norway rat

4UX8_A        447 RPKC-AELHYMVVATDQQTSR-QAQAQLLVTVEGS 479  human
XP_031812239  466 RPEC-TGMKYLVIASDRQSKK-QSRTTSTISVEGN 498 
XP_007478546  466 RSEC-TEMQYTVVASDRQSKK-QAKTLLIISIEGN 498 
XP_069045218  472 NKDC-QDLQYIVVAQERQNKQtQAKTQLTITLVGT 505 
4_pfamImport   81 RPEC-QDLQYLVVAEEEHTQL-EASTQIHIILDAN 113 
XP_004077559  474 RPEC-QDLRYAVVAQEEFKEL-ETSTQIQVLLDGE 506 
XP_023183794  475 KPGC-QDLDYTVVAQEEQTQL-VASTQIRILLHGE 507 
XP_015462110  473 RQECfQDLEFVLIAKEQQRHL-EAKTQLLIRFEGE 506 
KPP59675      432 QPEC-RKLHFTLEAQEKKTQL-QAKTELVIQFNGN 464 
G3V9H8        476 RPEC-TELQYTVVATDRQTRR-QTQASLVVTVEGT 508  Norway rat
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