2RJP,2RJQ


Conserved Protein Domain Family
ADAMTS_CR_2

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pfam17771: ADAMTS_CR_2 (This model is not part of the current CDD release)
ADAMTS cysteine-rich domain 2
This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.
Statistics
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PSSM-Id: 522938
Aligned: 69 rows
Threshold Bit Score: 56.9648
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2RJP_A        227 PGKDYDADRQCQLTFGP-D-SRHCPQL-P-----P-PCAALWCSGhlngHAMCQT-KH-SPWADGTPCGPAQACMGGRCL 295  human
XP_009030721   80 PGQKFSVDQQCQFVFGP-G-SYFCSAGeEs---dEkVCEEMFCKNl--dEGQCKGgKM-YRAYDGTPCGNKRWCMGGKCV 151 
XP_009044635  288 PGQVYAPDQQCQMIRGS-N-SYFYRDGtQg----DnVCTNMKCVIgn------nY-TE-YTAAEGTSCGSKKWCHLGRCV 353 
XP_009062315  404 PGQEFTPDQQCTNIYGN-T-SYLCRGTsFgl--gEsICKAMFCRNph-tTRKCV---L-HSAAEGTSCGDRKWCHQGHCV 474 
XP_009056241  257 PGQYLDADEQCRIFYGNtK-SYFCRNEqLegfgfDlMCQRMYCYDps--sSSCQT-VI---AKDFTSCGSEMWCFQGACV 329 
XP_009046642  369 PGQYFNLDEQCAMKYNE-S-FTFCSFPyTsd--kDqLCYILYCFDg---KSNCL---S-ARVMEYTTCDVNKWCHRGLCI 437 
KOF93529      328 PGEVHNVHDQCRQIYGP-D-SFMCPPAyP-----SqICYKMMCYVps--tSKCVT-ESgLRAAIGTPCGHQKGCYFGNCL 397 
XP_009047018  357 PGQIYNAGNQCKLIFGP-K-SGFCSKGkMr----SsMCGQLWCKDpv-nNRTCRT-HSyLTALPGTKCAGGKVCHLGECL 428 
XP_009012964  282 PGRVLDPNVQCKLIFGS-Y-SYYYHYS-D-----KnVCNELTCRFyn------kT-NYvYLAYPNTTCGAHKSCQNGQCL 346 
XP_024349889  132 PGLRFTLNEQCALAMRQ-RgARFCGHS-------SpVCKQLHCYDvq--rGMCLP-VE-APWAEGSRCGYKRWCVMGQCL 199  Echinococcus ...
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