2X2U,7AML


Conserved Protein Domain Family
RET_CLD1
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pfam17756: RET_CLD1 (This model is not part of the current CDD release)
RET Cadherin like domain 1
RET is a single transmembrane-spanning receptor tyrosine kinase (RTK) that plays critical roles in the development of vertebrates. Structural analysis indicate that RET contains four consecutive cadherin-like domains (CLD). This entry relates to the first CLD at the N-terminal. Several regions within RET-CLD1 have been shown to be important for ligand-coreceptor binding. CLD1 and CLD2 have a distinctive clamshell shape and CLD1 is essential for CLD2 folding. CLD1 contains 2 sites for GDNF receptor alpha 1 binding.
Links
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Statistics
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PSSM-Id: 522928
Aligned: 19 rows
Threshold Bit Score: 179.045
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2X2U_A          1 LYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHlygTYRTRLHENNWIRIQEDTGLLYLQRSLDHSSWEK 80   human
1_pfamImport    1 LYFPQNEYTETVYVGQLAGTPILQVHAMLDSDSERSHFYLCWT---NPLRRPAYSSWFNLDINTGTLSLNKTLEESDFAS 77  
XP_005473896   27 LYVPQNEYIETVYVGQQAGTPVLQVHAMQDNKSEKPHFYLCPT---KTAMPSHYGSWFYMNINTGTLFLNKTLEESDFAQ 103 
XP_015462110   26 LYFPQNLYSETIYVGQPAGAPLLQVHSMRETSSERPYFSLCWR---NVQKPPLIAAWFHIDPVSGVLYMNKTLEWTDFDS 102 
NP_858048      23 LYFPQRLYTENIYVGQQQGSPLLQVISMREFPTERPYFFLCSH-------RDAFTSWFHIDEASGVLYLNKTLEWSDFSS 95  
XP_069045218   24 LYFPQKKYSENVFVGQPAGTPILQLHVMLDNESETAHFCLRQLt-eYPKIKL-----FHLDERTGLLSLNRTLDWSDFAP 97  
4_pfamImport    1 LYFPRKDYHENVYLDQPGGSPLLQIHALKDSEKEKIYFWLCPQl-hIPGVGIKDNLWFQIKEKTGLLFLNKSLDREDFET 79  
XP_004077559   30 LYFPQKEYIETVYVGQPAGTPVLQVHAMQDSAAERPHFSLCWA------RRPYYASWFHMDVTTGVLYLNRTLEPADFSS 103 
XP_023183794   30 LYFPQKEYTETVYVGQPAGTPVLQVHAMLDGRSERPHFYLCGS------RRPPYALWFQMDVQTGELSLSKTLEETDFAS 103 
7AML_A          2 LYFPQRLYTENIYVGQQQGSPLLQVISMREFPTERPYFFLCSH-------RDAFTSWFHIDEASGVLYLNKTLEWSDFSS 74   zebrafish

2X2U_A         81 LSvRNrGf-PLLTVYLKVFLSPTSLREGECq-WPGC----ARVYFSFFNTSF 126  human
1_pfamImport   78 LQ-HS-W--SVKKLFLLAMVIPTFTRKSQC--IRNS----PRITLDFVNATM 119 
XP_005473896  104 L--YQ-RsrSVRKLFLQTMVRSEFTNKPLCl-MRKP----VQIILDFVNATL 147 
XP_015462110  103 LSsSA-Fg-HAKKLILKVVAA-PGNQRSICl-HHTK----VDVSLTFLNTTA 146 
NP_858048      96 LRsGS-VrsP-KDLTLKVGVSSTPPMKVMCt-ILPT----VEVKLSFINDTA 140 
XP_069045218   98 PS-NS-WtgPVKKLPLLARASQKPFRDKSCh-GQTVhgqdVSIYINFYNTTA 146 
4_pfamImport   80 LFaGN-Wm-SMPKLILQVYLTSQPLQGKDCreSYNK----ALVKLSVINGTM 125 
XP_004077559  104 QYpTS-W--PVKRLSVQAVVSNSFIKGSQCa-AKRK----ALITLDFVNATM 147 
XP_023183794  104 LYqNS-W--PAKRLTLQVMALNSVSKRAPC--SRNS----AHITLDFVNGSM 146 
7AML_A         75 LRsGS-Vr-SPKDLTLKVGVSSTPPMKVMCt-ILPT----VEVKLSFINDTA 119  zebrafish
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