Conserved Protein Domain Family
DUF5575
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pfam17738: DUF5575 
DUF5575 central RNaseH like domain
This entry represents the central domain from a family of Chordate proteins that includes C19orf68. These proteins appear to be transposon related. This domain appears to be closely related to the MULE RNaseH domain pfam10551.
Links
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Statistics
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PSSM-Id: 496687
Aligned: 3 rows
Threshold Bit Score: 324.943
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007492705 288 IRTTNKISKQFVAPEDIHRLLSYCKSRDHGVLDALRVLEGLFQADPEAKVKLVFVEDQAIVETVFFLTSSMMALLRRYPL 367 
2_pfamImport   1 VRTTNKISKQFVGGPDVRRLLSYCKSRDHGVLDVLTVLDGLFASDPGAKVKLVFMEDKVIVQTIFFLSSRMMALSRRFPL 80  
Q86XI8       148 VRTTNKISKQFVAPADVRRLLSYCKGRDHGVLDALHVLEGLFRTDPEAKVKLVFVEDQAVVETVFFLTSRTRALLRRFPR 227  human

XP_007492705 368 MLFFDRLPGLQGTFDLSTVLCVDDFGQGREVACCLTRQTSPNLLRFTLASLVQSVPEIKGRVGCVTVGPEVgTQLEAVRE 447 
2_pfamImport  81 MLFFDRMVGLNEEFDLYSVLCVDGAWHGRAVAYCLTQQDTPDLLRFMLASLVQSVPEVKLQVRCVTLGMEI-AHLEAVKE 159 
Q86XI8       228 MLLVDRLPGLQGALDLLAVLCVDGSGRARQAACCVARPGTPSLLRFALASLLQSAPDVKGRVRCLTAGPEVaAQLPAVRQ 307  human

XP_007492705 448 LLPGARVQIC 457 
2_pfamImport 160 LLPNARVQIC 169 
Q86XI8       308 LLPCARVQIC 317  human
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