Conserved Protein Domain Family
YBD
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pfam17725: YBD (This model is not part of the current CDD release)
YAP binding domain
TEA domain transcription factors contain an N-terminal TEA domain pfam01285 and a C-terminal YAP binding domain (YBD). This entry corresponds to the YBD that binds to the oncoproteins YAP and TAZ. The structure of the YBD shows that it has an Ig-like beta sandwich fold.
Links
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Statistics
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PSSM-Id: 522908
Aligned: 5 rows
Threshold Bit Score: 321.351
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_004995253 203 LRLALDYFSAGITyp--fhQGVHKFFELsgsyhfaDPSMEC--IDLYQIADKFPQ-LEELYRAGP-KEAFFLVKVWADLN 276
XP_045092271 267 SKLSLHGFSAYVQcn--ktLERTELVKI-------DNTLEKdhIDISLFYEKYPRlLRELFEKAErKDVFFLAKCWANIN 337
XP_001746963 189 LRLALDYFHAFVDyp--mgAGSHNFVELtgsyhfaDPQMEC--IELSQIADKFPR-LHEAYLQGP-PEAFFLVKFWVDMT 262
VDN06351     165 SMLTLCGFIAYVEpipsdiTSRVDLVRIpk---laDEPLEAhtFKLEDIAEKYPPvLGELFAAGP-RDGFFLVKCWANID 240
XP_024510141 236 SKLVLCGFTAYIRen---tGEQIDIVKInq---isDEPLES--IKFDLIASKFPEeFRVLFDEGP-PDSFFLAKCWGNLA 306 Strongyloides r...

XP_004995253 277 ydaeqttqiaHEDDNGNinpqpsdAIFNLATRFESLERMPVECRTSAISLGNVAAEKIQVTEPRYEGGRFLYDLTSGTMC 356
XP_045092271 338 ----------VSDDVQN-------CQYAVDSLYASREKFQLKVSTMACSFGSQAVEKIEQYFPIEVDGSYSFMLNNSPMC 400
XP_001746963 263 fdpnq-tmhaMADTETPghgindrSFFGLTCRFESLECMVVEISMCAIQLGKPVVEKIHVEEPIHDQSRYVYAMNRSPLC 341
VDN06351     241 f--------nLPDDNS--------ALYAVDSFYESTQRFDITVSTKVCSFGKQVIEKVEIYSPVENGRKFNFRLEGSPMC 304
XP_024510141 307 f--------nLPSEDRKa-----nVIYAVDSFYDSLTKFDISVSTKAITFAKQIVEKVEVYSSVQKDNRYHFALESSPMC 373 Strongyloides r...

XP_004995253 357 EYMTQFISHL-HGVNGVDVINLVLENFAVMQVVRSQTTGEVLFSMACLFEAVPPGTPTgVHVYKL 420
XP_045092271 401 DYMVKFIAEL-KKLNAIETMNNVLENFTVLQIVTNSETDELLMVLCFVFEVSQEPEPS-CSVYRL 463
XP_001746963 342 EYMATFAQRL-RALDDIDMMNKVLENFHVTQTVRNQSTGEVLFSFACVFEVAKPGLGCgHHVYKL 405
VDN06351     305 EYMVKFVAEL-KKLQSHDLMNSVLYNFTVLQVVTNRETKEPLMVIGFVFEVSPVPEST-CRLYRL 367
XP_024510141 374 EYMVDFITKLiKEVSGNELKNRVLENFTVLQVIKNRQTNETVMTIAFMFEVSPDPDPT-SRLYRL 437 Strongyloides ratti
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