Conserved Protein Domain Family
GCP_N_terminal

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pfam17681: GCP_N_terminal (This model is not part of the current CDD release)
Gamma tubulin complex component N-terminal
This is the N-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast. Furthermore, family members such as human GCP4 (Gamma-tubulin complex component 4) have been structurally elucidated. Functional studies have shown that the N-terminal domain defines the functional identity of GCPs, suggesting that all GCPs are incorporated into the helix of gamma-tubulin small complexes (gTURCs) via lateral interactions between their N-terminal domains. Thereby, they define the direct neighbors and position the GCPs within the helical wall of gTuRC. Sequence alignment of human GCPs based on the GCP4 structure helped delineate conserved regions in the N- and C-terminal domains. In addition to the conserved sequences, the N-terminal domains carry specific insertions of various sizes depending on the GCP, i.e. internal insertions or N-terminal extensions. These insertions may equally contribute to the function of individual GCPs as they have been implied in specific interactions with regulatory or structural proteins. For instance, GCP6 carries a large internal insertion phosphorylated by Plk4 and containing a domain of interaction with keratins, whereas the N-terminal extension of GCP3 interacts with the recruitment protein MOZART1.
Statistics
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PSSM-Id: 522884
Aligned: 157 rows
Threshold Bit Score: 104.676
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4WSG8       169 FHALFRLgL-GWN-SVLFRYNKqRKAferv-sdnIRV---SGVSLAVVN---GLTEEVLRCGTAMYNLRDFARR------ 233  Aspergillus fu...
KXN65469      86 IEDCLNI-LlGIN-GNFIGFNV-DRNtnt---ieLVM---SNLIPIRYL---ALIEQITKGGIFLYYIKLYLNQfskykf 153 
XP_011124834 199 VYCLLHL-VkGWD-SMLFKFNE--AN--------MEF---EAT-REGLRlsgTLISHYLKCGNRLRALQAFAKTv----- 257 
EPS45319     186 IYCLLHL-AqGHD-SFLFRFNA-DKMefemtrenLRI---SGASVGATE---KVVGKYRKCGNQLRTLQAFAas------ 250 
GAD96537     178 FQSLFRL-GlGWN-SIFFRYNE-QKRifdkelrdVRI---SGVSLPAVD---GVIRDISQCGTGLQRIRAFVRT------ 242 
CEO58992     174 IRSLLRLgL-GWS-SSFFRYNEqTKTferc-mndVRV---SGVSLAMLD---SVISSVLQCGTNMQHIRAFVKN------ 238 
KGO68243     174 IRSLLRLgL-GWS-SAFFRYDPhTNQferh-lnnIRI---SGISLLALE---NMIQSVVQCGTKMQHMRMFAQD------ 238 
XP_014536274 174 IRSLLRLgL-GWS-SAFFRYDQrTNEfkrh-lkdIRV---SGTSSMVLE---NVIEHVAQCGTNMQRMRLFAQD------ 238 
Q0D0R6       173 FRSLFRLgL-GWS-SMFFRYNQ-QQAqfervfkdVRV---SGISLTALS---GLVDEMIRCGTDMQRVRNFVIKtp---- 239  Aspergillus te...
Q383E4       202 ISDMLFM-WmGVDkTKYFAYDN--AC--------CRYemnSGYGTVRQR---QAFSAFQECGCLAHQIDDALRGgtse-r 266  Trypanosoma br...
Q4WSG8       234 ---TRIKPEGFSaRSaFASAVAMiIYTLEKQIInyfkevSSLIQIMTLFQRCGDLVGALSNIVE-----AVQkaAS---- 301  Aspergillus fu...
KXN65469     154 glvHQALGASIN-LL-LEDYYLL-VNQLEFQLKqk--tlTNLSQLIYYLNSNLLILEYLTKLLSkfthpDVDeqGKatev 228 
XP_011124834 258 ---yADIGSCCKtRVgLAHCIQIiTVAVQHRLTvlftsiQSILQLDDIIKVPTMILEALLKIVE-----RVKdtRL---- 325 
EPS45319     251 --vyADSSNACKtRVaLAACVQIvNVAVQHRLTvvftdiKSLLQLDDIVNVPALILDALLQIVD-----KVKskKL---- 319 
GAD96537     243 ---NPAVSDQPTaLStLAAAVAIlVYSLEKQLSeryyqqGSLLQIQTLFQRCGDLVGTLVNILD-----GVEkvKS---- 310 
CEO58992     239 ---APTKPKDLFsLFtLRGTVAIiIYNLEQQILlysqniVSVLRVMTLFQRCGDLISALADVVN-----MAEkaKS---- 306 
KGO68243     239 ---PPAKCKELPaLFtLSSTVAViIINLEQQISdhskniASLLQIKALFHRCGDLIGVLAGIVG-----AAQkaVS---- 306 
XP_014536274 239 ---PPAKCRKLSaLFtLSSTVAViIFNLEQQISdqsksiASLLQIKAMFHRCGDLIGVLAAVVG-----AAQkaVS---- 306 
Q0D0R6       240 --sGSGIPSALS-TL-SSAAAVI-VYTLEAQLVrnykqaVSVLRIKSLFEPCREIVAALANIIE-----SIEgpTT---- 305  Aspergillus te...
Q383E4       267 sflQQSLRGAVR-RH-LSQYHTL-VASFRGRQTp----pMAFGDLVVAFKRVQPKLRVLHTMLK-----ETE--NVk--- 329  Trypanosoma br...
Q4WSG8       302 --DAQVISAVIEk--AAH-YSEAfgSMENLFRELVARVIAPWLQYVEAWVGlRTETpaLvDLAakSE-GFVAVERYEGRA 375  Aspergillus fu...
KXN65469     229 lvGAKVIDYLYDqmlKMS--GFQ--TIKSLYGYLLSQTIIPYLSMTYSWIF-RAEL--T-DPF--NE-FLVYLKTSTQTQ 297 
XP_011124834 326 --DFQLLSAIFEq-iQRSeYKSD--WLRYLLLLMLQRITRPWLTMVSKAIGiTVEKtpFvDDIfeDEgFFIELGDPVLQ- 399 
EPS45319     320 --DYQLLSVTFNq-iQQSeYQSD--WLRKLLLLMLQRITHPWLTMVSKAIGiLIEKsaFsDDIfeDEgFFIELEEPSPR- 393 
GAD96537     311 --EGEVVSTVLAk--CDH-FSQRfvWMADLLSELTFRVTQPWLGLVETWLGlRGEErgLpELT--SN-GFIEAEYFEDPT 382 
CEO58992     307 --DAQVISAVIEr--ATV-FTHMfgWMENLLQEIVFRVTSPWFEFVERWIGlRSDEgaLsELVasGR-MFVQLEHHHDPT 380 
KGO68243     307 --DAQVMSIVTEr--AAF-FAQQfgWMENLVHEIVIRVTRPWFKFIETWIGlRPEDtaIkASMasGK-TFVRLDTHDAVK 380 
XP_014536274 307 --DAQAMSIVVEr--AAF-FAQKfgWMENLLHETVIRVTRPWFKFIENWIGlTPEEtaLtASMasGK-TFVRLDTHDAAK 380 
Q0D0R6       306 --ESQIISIVLAr--AAH-FSQTfaHMENLFREIATRVARPFLDHIESWVGfRSETptSkEFArsGR-SFVSLRHPEESD 379  Aspergillus te...
Q383E4       330 --GGELASKLQR---LVQ-QGSR--RLCALLSDVYMEAVSPLLHMTVSSII-KGDV--S-DPF--NE-FFVKSDPRVED- 393  Trypanosoma br...
Q4WSG8       376 GS--------------------------------RSMKASSLQYRYHPEQMPTFIPAEQADLIFETGRSLRLLRRYhpqh 423  Aspergillus fu...
KXN65469     298 AQnqqnltnlsiqtspqyqqatlntsnlpsqlelEEKKINPEDYEFNPDNLPKIMGN-LGEKIWLSGKHLLLLKSC---- 372 
XP_011124834 400 ----------------------------------EGEEEPHTDLIFAPSNIPSFLMLEEAERVHETSRGLRLLRRFhpdh 445 
EPS45319     394 ----------------------------------EGEEEPHIDLVFIPSNIPSFLTLEEAERIYETARGLRLIRRFypeh 439 
GAD96537     383 GRktep---------------------------------kivDYIYHPEMMPSFIPEQQARLIFESGRSLRILKQShprh 429 
CEO58992     381 KFktgs---------------------------------ertEYIYVDAHMPSFIPKDQARTIFESGRSLRLLKRSdphh 427 
KGO68243     381 LKtrp----------------------------------ariDHIYQEDHMPSFIPADQARSIFESGRSLQLLKRShprh 426 
XP_014536274 381 ----------------------------------IKTGLARIDHMYQADHMPSFIPADQARSIFESGRSLQLLKRShprh 426 
Q0D0R6       380 KQiska---------------------------------emdHYIYCPEQMPSFVPSDQAKLIFESGRSLRLLKRFhprh 426  Aspergillus te...
Q383E4       394 ----------------------------------TSDTFWSSKFSLLPDMLPTTVSYSLAERIRLVAKNVSFIRNCc--- 436  Trypanosoma br...
Q4WSG8       424 pianda-iltkdspnlrCAGswsdierIQKKAQqyetqlrseilkysqgqrvgqvemd---------kvlaeeqmqkfvs 493  Aspergillus fu...
KXN65469     373 -----------------GVRld---ssIEDNLP----------------------------------------------- 385 
XP_011124834 446 pllsg---hgvervkmrWSfswdelqaID-LEAaahekrlqlamqafnltkrsrfsrltdhp-qlggndgfsfdfigkse 520 
EPS45319     440 pllvd---hsierhvmrWNfsweelqaID-LEAathekrlqlamqsfnlnrnsrfrkpsnpsratgihrtyefecfgktd 515 
GAD96537     430 pigrddilrttsppalhCAIsfqdierIQDKASdyehrlrseilryirgdsseakc------------llpanggdirdv 497 
CEO58992     428 piarhdvlpgaknlrlyCATtwsdierIQRQANeheaslrheilkyhrghnskq----------------paeldtpasr 491 
KGO68243     427 piarrdvllrtgglhlhCATtwadieqIQTKAQeyesslraeikryhkgdtglqdp-------------psnvithgvdk 493 
XP_014536274 427 piarpdvlfrtgglhlhCATtwagiehIQTKAQeyesilraeikryqdgdadlqds-------------psnvasrdvgh 493 
Q0D0R6       427 piang----kfrnstldCARswaeierIQSKAQtyerelraeilkynrhgsfeke---------------rcdftpehlv 487  Aspergillus te...
Q383E4       437 ----------------rCKQwhm-dpsIVAAAQ----------------------------------------------- 452  Trypanosoma br...
Q4WSG8       494 agddpaispafELf-dIDDSKhttgllasdsslendelgplfdastlevsrpihphrknfgpemisavslsLAPLLSSQA 572  Aspergillus fu...
KXN65469     386 -----------EIrkggv-------------------------------------------------ncpdYIKAIDTAY 405 
XP_011124834 521 eeikaslaaslEN---MN-FEpqrqfgfegaaddklgnealtve----pitsnqpttaryppplsvtfslsINPILQAQA 592 
EPS45319     516 deiqtglatslSN---MN-IEperkfgfegdtdhslgneaftve----ptqpqrmssakyppplsitfslsLNPILQAQA 587 
GAD96537     498 emaddpikstfEIi-dVDDARhvtglladssslesdklyriltgsdgldieqamtsdspfgppltsafhlsLAPIISAQA 576 
CEO58992     492 qpscgnlngtyELf-dLDDEKiisgsvvdqralvndkinqllektr-epasdyvddasrfgpelssalylsLAPVISSQA 569 
KGO68243     494 tadkevttaafELf-eIDDEKnaswpvtdhralsksdfkqlldkar-rsdieninetsylgpeftsglhlsLAPILSSQA 571 
XP_014536274 494 taetevttaafELfdlDEknasgpvtdhkalskddfkhlldka---rgfeidhtsegthlgpelmsglhlsIAPILSSQA 570 
Q0D0R6       488 ldgdnvvsgafDLf-dMDSAKvtgllnnqasvesdplgqlvda------gsivtgnenafgpelaaslylsMAPFLSSQA 560  Aspergillus te...
Q383E4       453 ----------------SATFDt-------------------------------------------------LDSVVRDAM 467  Trypanosoma br...
Q4WSG8       573 LLVDFSCLHLLFKE 586  Aspergillus fumigatus
KXN65469     406 SYANTTLLNYIFRE 419 
XP_011124834 593 RLTNMACMRLLFKE 606 
EPS45319     588 RLANMACMRLLFKE 601 
GAD96537     577 RLIDFSCLHLLFKE 590 
CEO58992     570 QLIDFSYLHHLFKE 583 
KGO68243     572 LLIDYSCLHLLFKE 585 
XP_014536274 571 LLIDYSCLHLLFKE 584 
Q0D0R6       561 SLIDFSCLHMLFKE 574  Aspergillus terreus NIH2624
Q383E4       468 RFTNTAVLRLIREE 481  Trypanosoma brucei
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