8U5Y


Conserved Protein Domain Family
RADX

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pfam17659: RADX (This model is not part of the current CDD release)
RPA-related protein RADX
This entry includes RPA-related protein RADX from animals, the human member is also known as CXorf57. High-throughput sequencing used to identify genes driving tumorigenesis in Avian leukosis virus (ALV)-induced B-cell lymphomas, showed CXorf57 as the 10th most frequently targeted common integration site by ALV. ALV induces B-cell lymphoma and other neoplasms in chickens by integrating within or near cancer genes and perturbing their expression. RADX is a replication factor A protein-like (RPA-like), single-stranded DNA binding protein recruited to replication forks to maintain genome stability. It also modulates stalled fork protection by antagonising RAD51. These proteins consist of four tandem OB fold domains.
Statistics
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PSSM-Id: 522866
Aligned: 8 rows
Threshold Bit Score: 1710.84
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8U5Y_B         2 SGESGQPEAGPSHAGLDWPNPERNRAGVPGGVIRRAGSQGPRSWIQKVLEQIMDSPRQCVTPSEVVPVTVLAVQRYLLED 81  human
XP_006082405   2 PGELDQPQAGASHAGMVRQDSEVNGPWVPGGVRPKAGALGPRSWIQTVLEQVRDSPLQWVTPSEVAPVAVLAVQRYLLED 81 
1_pfamImport   1 SGKSGQPEAGPSHAGQDQRRRERDRAGVSGGVIRRAGAQGPRSWIQKVFEQIIDTPRQWVSLSEVVPVAVLAVQRYLLED 80 
XP_002720218   2 SDESEQPQEGPSGAGLDWSNLERNRAGVPGGVIRRARGQGCMSWIQKVLEQIIDSPLKWVTPKEVAFVSVLAVQRYLLEE 81 
B2GV47         2 SGESDQPQPGPSHAGLYLEHRERDQAGVPGGVIRRAGSQRHRSWIQTVIEQITGSPRQCVTLSEVVPVSVLAVQRYLLED 81  Norway rat
XP_003918135   2 SGESGQPEAGPSHAGLDWPNPERNRAGVPGGVIRRAGAQGPRSWIQKVLEQIMDSPRQCVTPSEVVPVTVLAVQRYLLED 81 
2_pfamImport   1 SGESVQPQAGPSHAGFDFPYPEPIRAAIVPGGVIRRAAPAPKSWIQKVLDQIIGSPRQWVTPSEVVPVTVLAVQRYLLED 80 
XP_005227896   2 SGESGQPQADPSQAGVDMPHPERNGAAVPRGVVRRVGALGRRSWIQKVFEQVIDSPRRWVTPLEVVPVAVLAVQRYLLED 81 
8U5Y_B        82 EPRDTVPKPPLYCYDVTISDGVYQEKCYLDPSLNSLVYQNILKVGIQMRISRVSCLYNEKRIGQGILCIDNVHC-GETSD 160 human
XP_006082405  82 EPGDILPKPSRYGYDVTISDGVYQEKCCLHPRLNFLVSKNILRPGIKMRIFRVSCLYNEKRLGQGILCIDNIDCkEETLD 161
1_pfamImport  81 EPRDMLPKLPLYCYDVTISDGVYQEKCYLDPRLNSLVYKNILKVGKEVRITRVSCVYNEKRIGQGTLCINKVHC-GETLK 159
XP_002720218  82 EPNDTVRGGPLYCYDVTISDGVYQEKCYLDPSLNSLVYKNILKVGIEMKISRVSCLYNEKRLGQGILCIDNVQC-GRTLD 160
B2GV47        82 EPRDTVPKPPLYCYDVTISDGVYQEKCYLDPSLNFLVYQNILKVGIEMRISRVSCLYNEKRLGQGILCIDKVHC-GEPLD 160 Norway rat
XP_003918135  82 EPRDTVPKPPLYCYDVTISDGVYQEKCYLDPSLNSLVYQNILKVGIQMRISRVSCLYNEKRIGQGILCIDNVHC-GETSD 160
2_pfamImport  81 EPRDIIPNLPLYCYDVTISDGVYQEKCYLDPSLNFLIYQNILKVGIEMRISRVSCVYNEKRLGQGILCIDNVHC-GETLD 159
XP_005227896  82 EPRNVKPKPPLYCFDVTISDGVYQEKCYLDPSLNSLVYKNILKVGIEVRIFRVSCIYNEKRIGQGILCIDNVLC-GELLE 160
8U5Y_B       161 SISLETPFRNRAHQEKPERPLRGGKSHYLALWNNEDPYGDIWLTDKQPEEHNFSDTKIISLSHLEMTWTNRRNFPALLVR 240 human
XP_006082405 162 TISLATPFRNSAHQEIPERPLRGGKSHYLALWNNEDPYGDIWLTNKQPEEYNFNNTKIISLAHLEMSWTKRTNYPALLVR 241
1_pfamImport 160 AISLETPFRNRAHEQKPERPLRGGKSHYMALWNNEDPYGDIWLTSKRAKEYNLSTIKIISLSHLEMTWSTRKNFPALLVR 239
XP_002720218 161 AISLETPFRNRAHGVKPERPLRGGKSHYLALWNNEDPYGDIWLTDKQPKEHNFTNTKIISLSHLETTWTDRNDFPALLVR 240
B2GV47       161 VISVETPFRNRAHEEKPERPLRGSKSHYLALWNNEDPYGDIWKTNKQPEEFNFNNTKIISLSHLEMTWHNRKNFPALLVR 240 Norway rat
XP_003918135 161 SISLETPFRNRAHQEKPERPLRGGKSHYLALWNNEDPYGDIWLTDKQPEEHNFSDTKIISLSHLEMTWTNRRNFPALLVR 240
2_pfamImport 160 TVFVEIPFRNRAHGEKPDRPLRGVKSHYLALWNNEDPYGDIWLTNKQPAEYNFSDTKIIALSHLETTWFNRRTFPALLVR 239
XP_005227896 161 SVSLETPFRNSAHREVPERPLRGEKSHYLPLWNNEDPYGDIWLNNKQPKEHEFNHTKIISLSHLEMTWSNTKNLPPLLVR 240
8U5Y_B       241 ILHKSKLRYYGKPDKKMIEPYQTFLEVADSSGTVSVIMWNALCPEWYKSLRVGLVLLLQDYSVKKSYPFRIQPVPVDPQI 320 human
XP_006082405 242 IMYKSRLRYYGKPDKKMIEPYQTFLEVADSSGTVSVIMWNALCPEWYKCLRVGSVLLLQDYSVKKSFPFRLQPLPVDPQI 321
1_pfamImport 240 ILYKSKLRYYGKPDKKITEPYQTFLEVADSSGMVSVIMWNALCPEWYKSLQVGLVLLLRHYTVKKSYPFRMQPPPVDPQM 319
XP_002720218 241 ILRKSKLRYYGKPDKKTIEPYQTVLEVADRSGTVLVILWNALCPEWYKSLRVGLVLLLQDYSVKKSYQFRMHPLPVDPQI 320
B2GV47       241 ILHKSKLRYYGKPNKKMIEPYQTYLEVADSSGMVSVIMWNALCPEWYKSLRVGLILLLQDYSVKKSYPLRIQPDPVDPQM 320 Norway rat
XP_003918135 241 ILHKSKLRYYGKPDKKMIEPYQTFLEVADSSGTVSVIMWNALCPEWYKSLRVGLVLLLQDYSVKKSYPFRIQPVPVDPQI 320
2_pfamImport 240 ILQKSKLRYYGKPDKKMIEPYQTFLEVADSSGTVSVIMWNTLCPEWYKSLHVGLVLLLQDYSVKKSYPFRMPPLPADPQI 319
XP_005227896 241 ILYKSKLRYYGKPNKKIIEPYQTFLEVADSSGTVSMIMWNTLCPEWYKSLHVGLVLLLQNYSIRKSYPFRMQPLPVDPHI 320
8U5Y_B       321 KLISTMEICLNLRDPPtNIIIIPEKQVKPEWRLPKLNHRFTTRSELDDMPENCICDVIGLLVFVGRVQRSKKKENREDFW 400 human
XP_006082405 322 KLISTMEVCLNLRDPPtNINIIPEGQVKPEWRLPKLNHRFITRSELDDIPEKQICDVVGVLVFVGRVQRLKKKEYGEDFW 401
1_pfamImport 320 KIISKIEICLNLQDPPaNIKIIPETQVQSEWRLPQLNHRFVTRSELDNLPENHLCDVIGILVFVGRVQRLKKKENSEDFW 399
XP_002720218 321 KSISTMEIGLNLRDPPtNIIIIPENQVKPEWKLPKLNYRFITRSELDDMPKDSICDVIGLLVFVGRVQRSKKKENREDFW 400
B2GV47       321 KLISTMEICLNLRDPPtNIVIIPEKQLKSEWKLPKLINRFITRSELDDMPENSICDVIGMLSFVGRVQRSKKKENSEDFW 400 Norway rat
XP_003918135 321 KLISTMEICLNLRDPPtNIIIIPEKQVKPEWRLPKLNHRFTTRSELDDMPENCICDVIGLLVFVGRVQRSKKKENREDFW 400
2_pfamImport 320 KVITTMGICSKLPFNRsNVLMLEDKQLHISFKLEKLRCHFFKESELDDMPENRICDVIGLLVFVGRVQRSKKKESREDYW 399
XP_005227896 321 KLISTMEICLNIRDFP-NIIIIPEKQVKPEWRLPKLNHRFVTRSELDKMPNNYICDVIGVLVFVGRVQRSKKKESREDFW 399
8U5Y_B       401 SYRWIHIADGTSEQPFIVELFSTSQPEIFENIYPMAYFVCTQLKVVRNDNQVPKLLYLTTTNESGVFIT-GHR-GQPYTY 478 human
XP_006082405 402 SYRWIHIADGTSEQPFIVKLFSTSQPEIFENICPMTYFMCTQLKVVRNNNQVPKLLYLTTTNESQIFII-GHR-GQPYAN 479
1_pfamImport 400 TYRWIHIADGTSEQPFIVELFSTSQPEIFENLYPMTYVLCTQLKVVRNNDQVPKLLYLTTTNESQVFIT-GGQkGQPYAY 478
XP_002720218 401 SYRWIHIADGSSEQPFIVELFSTSQPEIFENIHPMTHFMCTQLKVVRNDAQVPKLLYLTTTNESRVFIT-DLN-DQPYTN 478
B2GV47       401 SYRWIHITDGTSEQPFIVQLFSTSQPEVFENIYPMTYFVCTQLKVVRNNSQVPKLLYLTTTNESRVLIT-GHR-GQPYTY 478 Norway rat
XP_003918135 401 SYRWIHIADGTSEQPFIVELFSTSQPEIFENIYPMAYFVCTQLKVVRNDNQVPKLLYLTTTNESGVFIT-GHR-GQPYTY 478
2_pfamImport 400 SYRWIHIIDGTSELPFIVELFSTSQPEIFENIYPMSYFVCTQLKVVRNDTQTPKLLYLTTTNESRVFMTgGHR-GQPYTY 478
XP_005227896 400 SYRWIHIADGTSEQPFIVELFSTSQPEIFEHIYPMTYFTCTQLKVVRNDDQVPKLLYLTTTNESHIFMT-CHK-GQLRND 477
8U5Y_B       479 DAKVKNFIQWIRTKSDSGEQKNMVIGGYYPYPPVPETFSKYSSSIKVESLLTAISEVRKEIEDLQYREQKRIAIQGIITA 558 human
XP_006082405 480 DTKVKSFIHRIKTKTDSGEMKNTVIGGYYPYPPVPETFSKYSTSVKVQSLLTAISEVRKEIENLQYREQKRIAIQGIITI 559
1_pfamImport 479 DVKVKNITQWIKTKTDAGEMKNTVFGGYYPYPPVPETFSKYSSSVKVESLLTAISEVRKEIEDLQYREQKRIAIQGIITV 558
XP_002720218 479 DTKVQNFIQWIATKTESGEVKNTVIGGYYPYPPVPETFSKYSSSVKVHSLLTPVSEVKKEIEVLQYREQKRIAIQGIITV 558
B2GV47       479 DTKAKKIIQWIKT-KTNLEAKNTVIGGYYPYPPVPETFSKYSRFIKAESLLTTISEVRKVIEDLQYREQKRIAIQGIITA 557 Norway rat
XP_003918135 479 DAKVKNFIQWIRTKSDSGEQKNMVIGGYYPYPPVPETFSKYSSSIKVESLLTAISEVRKEIEDLQYREQKRIAIQGIITA 558
2_pfamImport 479 EAKVKNFIQWIKTKTESGEVKNTVIGGYYPYPPVPETFTKYSSSVKVESLLTAMNEVKKEIEDLQYREQKRIAIQGIITV 558
XP_005227896 478 DAKVKNFIQWVKEKNDSGEGKNTVIGGYYPYPPVPETFWKYSSSLKVESLLTAISEVKVEIEDLQYREQKRIAIQGIITV 557
8U5Y_B       559 IKYIPHSSATESASASETLRNANRPSTSQAARVEIQERNGKRHQDDEPVn-SQYFQTTSTNLSLSNKIRILQGPHANPVA 637 human
XP_006082405 560 IKYVPHSSATGSSSASETVQNVNQPSTSQTAIKESQSQELDGKQHQDDG--SVSCQTTCTSLSPPKKKRILQGPFAKLVP 637
1_pfamImport 559 IKYIPDRRATESASTSETLRNANLPTTSQAARGESQSQERDGKRHHHDGd-PVSSQTTSSSLSPSKKKRVLQGPDAKVVA 637
XP_002720218 559 VKYIPHSSAAESASASETYQNADQTSTSKASREESESQGRISTWHQYDRs-MSSQCFQPASLSPSNKRRILQGPYSKPFA 637
B2GV47       558 IKYIPYNHSAKSAPASETLQNASPPSTSQAAAKEGHYHERGSKRSQDDRp----MDSLPMVLSLCAKRKILQGPTANPVP 633 Norway rat
XP_003918135 559 IKYIPHSSATESASASETLRNANRPSTSQAARVEIQESNGKRHQDDEPVn-SQYFQTTSTNLSLSNKIRILQGPHANPVA 637
2_pfamImport 559 VKFIPHSSA-----------------TESATASEIPWINRPSTSHDDEPmsFQSFQNASISLYTSNKVRVLQGPIAKPVI 621
XP_005227896 558 IKYVPYHSATQSASASETLRNAKRPSTSEAARKESQSQEKDGKRHHDDGsgRSQCHSACASSNPVPKKRITQTPSGKQIP 637
8U5Y_B       638 VPQPGASVQTKGIKPGMPSIFNR-RANINANLQGKARKTISDRWESQLWREKKFGLIDHLHYSRVYPESIPRKFMFEHRK 716 human
XP_006082405 638 IPQPETSAQTRENIPDTPSIFQR-RESASTGIKWKARKTLTHRWESQLWREKKFGLREHLCYRFVYPESIPRKFIFEHKN 716
1_pfamImport 638 VPQPETSSQAKGNKPDMPSTVRR-QESTSTHSLGKARKPISDKWESQLWREKRFRLIDHLHYSHVYPESIPRRFIFEHRE 716
XP_002720218 638 VPQAEASTQTYGTRIGMLSIFQ-----RQESFGGKTGKILSDRWESQMWRDKKYHLIDHLHYSRVYPESIPRKFLFEHRN 712
B2GV47       634 VPQPHSSAQMKGNKPNIP----S-RENSTANATGKSKRIINDRWESQLWRDKKFSLRDHLHYGHVDPESIPRKFILGHEK 708 Norway rat
XP_003918135 638 VPQPGASVQTKGIKPGMPSIFNR-RANTNASLQGKARKTISDRWESQLWREKKFGLIDHLHYSHVYPESIPRKFMFEHRK 716
2_pfamImport 622 VTPPEAFLQAKGNRLFRPSIFQY-RDGTSSVIQLKARRTLNERWESPLWREKRLGLIEHLHYSNVYPESIPRKFILEHKK 700
XP_005227896 638 VPQPETSSQTKESKPSMPSSSDSgRENPSHTFVVRAKKTISDKWESQLWRDKKFSLIDHLRYSRVHPESIPRKFSSEHRH 717
8U5Y_B       717 FLSDQYNSQPAKYVPPEGRPPKLDDFKSARSLGHFEVTILGLNHEIAIDVAFLPMYCPEDIRTSQIDTLLTSMNYSCAYP 796 human
XP_006082405 717 FLIQQYICQPAKYIAPEERPLKVSDFKSARSPGHFEVTILGLNHERAIDVAFLPLYCPEDIRTSQIDTLLTCMNYSCVYP 796
1_pfamImport 717 FLTQQYNTQPSKYIPPEEGSPKLEDFKSACSLGHFEVTILGLNHEIAIDVAFLPMYCPEDVQTSQIDTLLTCMNYSCVFP 796
XP_002720218 713 FLAQQYNSQPAKYIPPEERPPKLEDFKSARSLGHFEVTILGLNHDIAIDVAFLPMYSPEDVRTSQIDTLLTCMNYSCVYP 792
B2GV47       709 FLTQQFNSQPAKYVPPEGKPPKLDEFQSARSLGHFEVTILGLNHEIAIDVAFLPMYSPEDVETSQIDTFLTCMNYSCVYP 788 Norway rat
XP_003918135 717 FLSEQYNSQPAKYVPPEGRPPKLDDFKSARSLGHFEVTILGLNHEIAIDVAFLPMYCPEDIRTSQIDTLLTSMNYSCAYP 796
2_pfamImport 701 FLIEQYNSQPAKYIPPEGKPPKLDDFQSARSLGHFEVTILGLNHEIAIDVAFLPMYSPEDLRTSQIDTLLTSMNYSCVYP 780
XP_005227896 718 FLGQQFNSQPAKYVPPEGKVPKLDHFKSARSLGHFELTILGLNHEIAIDVAFLPMYSLQDAQTSQVDTLLTCMNYSCVYP 797
8U5Y_B       797 QDTTGNDRLPGPRAVAGDIIKAATELDRVHIVGILDICNLGNNKVEVYLHKIY 849 human
XP_006082405 797 QEVTDSERMPGTTALAGDIIKAVTELDRVHVICILDICNLGDNNVEVYIHKIY 849
1_pfamImport 797 PEVTGNDRLLGPRALAGDIIKAVTELNRVHIIGILDICNLGDDKIEVCLQKIY 849
XP_002720218 793 QEVTDSDQSPDPKALAGDIIKAVTELDRVHIVGILDICNLGNNKVEIYLQKIY 845
B2GV47       789 PAAPVSGRVPDPKAVAGDIVKAAADLDRVHIIGILDICNLGNNKVEVCLQKIY 841 Norway rat
XP_003918135 797 QDTTGNDRLPGPRAVAGDIIKAATELDRVHIVGILDICNLGNNKVEVYLHKIY 849
2_pfamImport 781 QEVANNDRLPGPRAVASDIIKAAAELDKVHIIGILDICNLGNNKMEVCLHKIY 833
XP_005227896 798 QASTSSEKTTGSRVLAGDIIKAVSKMDREHVICILDICNLGSNKAEVYLHKIY 850
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