Conserved Protein Domain Family
Trnau1ap
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pfam17654: Trnau1ap (This model is not part of the current CDD release)
Selenocysteine tRNA 1 associated proteins
This entry represents the C-terminal region of Selenocysteine tRNA 1 associated proteins (Trnau1ap also known as Secp43). Family members found in Eukaryotes have been shown to serve an essential role in the synthesis of selenoproteins, which have critical functions in numerous biological processes. Selenium deficiency results in a variety of diseases, including cardiac disease. Trnau1ap proteins harbor RNA recognition motifs (RRM) pfam00076 and Tyr-rich region found in the C-terminal. The Tyr-rich region (amino acids 185-225) is conserved among several mammals, including human, chimp, dog, cattle, mouse and rat. Furthermore, constitutive deletion of exons corresponding to the Tyr-rich region in mouse resulted in embryonic lethality.
Links
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Statistics
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PSSM-Id: 522861
Aligned: 34 rows
Threshold Bit Score: 82.7674
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007565154  186 GGQ-TQSYs-------SYN--------------PtqtgY----YGSHaagsqGGY-YPQWgGYDQYSgynsSGYGYnsGY 238
13_pfamImport   1 QDT-YYWYw------qSLPaalr-------vkpD---------FPSC-----QRH-YGS--QYEQQQ----GGYPP--GY 43 
NP_001341286    3 TTPlAENQ--------DED--------------P---------LEVT-----SQY-VAQ------------ADLKL---- 29 
KPP65146      176 YHQ-NQNY--------NYSynysnynnynnfqqP----Yy---QQPY-----QSY-YPQW-GYDQYN----SSYNY--GY 226
NP_001025137  186 YHNqNNTYn------tNYQ--------------Qq--yY----QQPY-----NSY-YPQW-GYDQYS-----GYNY--GY 225
XP_007231711  186 YHNqGHNYn------sNYQ--------------Qq--yY----QQPY-----NNY-YQPW-GYDQYN-----SYNY--GY 225
XP_069046984  185 YQH-NQNY---------YT--------------Q----Y----YQQY-----QNY-YSQW-GYDPYG-----SYNY--GY 218
EMP40377       89 FQR-YQSY--------NYN--------------D----Y----YQDY-----QNY-YSQW-GYDPYA-----DYNY--SY 123
XP_007488025   15 QSN-YFWYwqwmktelQLD-------------------HsgtyYQQH-----QTC-YLQS-DFEPYF-----EYNY--NC 60 
Q5T4I8         15 QNN-YYCYw------qSLPsair-------vkqE---------FQPS-----QSYrYGNW--YARQH----GSYLLs-GY 59  human

XP_007565154  239 nSGYnssynsgynynYGaygypPSghmmppppvg---mppmstdmtgA--VQGQEQTEdaDDDTtE------EPIPECDV 307
13_pfamImport  44 -SSG-----------RGaggngPNiysayetsgh---paetsllpkeA--TSLAQNQD--EDSL-E------DPNLHLNI 97 
NP_001341286   30 -PDL----------------------------------------------SNSLVSAS--QSVGvT------DPHLHLNI 54 
KPP65146      227 -GSYgtpp----pcpGMmgpppQMsmppmppmt------temnssteE--MQGSTEDA--GEEAvE------DPNPLLDV 285
NP_001025137  226 -NPY------------------AApppmmgppppmgmppmppdmqgsTeaHDGTEEVE--EDPS-E------DPNPQVDV 277
XP_007231711  226 -NPY------------------ATpppvphgmmg---pppmmppmppD--MNAATEQS--QDAT-EevedneDPNPQVDV 278
XP_069046984  219 -GPYgpap----sapGM-----ATplastdgtt------vgtdaqasA--EKSAEDAE--EEPV-E------DPALHMDI 271
EMP40377      124 -PSYd----------NM-----QAvgdsaigds------vltpavfeE--TPTVAESN--DELItE------DPQLHLDV 171
XP_007488025   61 -VFYgniq----dvsSAkentkDLae--------------------iPvmSEDWTTNN--DEEQtE------DPQIHLDI 107
Q5T4I8         60 --SYg----------CAvdgngKDcfsahetpeh---tagtlvmpkeT--TPLAENQD--EDPL-E------DPHLHLNI 113 human

XP_007565154  308 ELWNKDFMQHSEELYDALMNCRWEPLDSVDSPIP 341
13_pfamImport  98 EELNKEFMVKSEELYQSLMNCHWQPLDTVHSEIP 131
NP_001341286   55 EESNQEFMVKSEELYDSLMNCHWQPLDTVHSEIP 88 
KPP65146      286 DTLNKQYMERSEELYDSLMDCHWQPLDSVTSDIP 319
NP_001025137  278 EELNRQYMERSEELYDSLMECHWLPMDTITSDIS 311
XP_007231711  279 EVLNKQFMERSEELYDSLMSCSWQPMDSVASEIF 312
XP_069046984  272 DTLNRQFMERSEELYDSLMNCHWQPLDSVTSEIP 305
EMP40377      172 DEMNRQFMERSEELYDSLMNCHWQPLDTVTSEIP 205
XP_007488025  108 ENLNKEFMVESEELYDSLMNCHWQPLDTVASWIP 141
Q5T4I8        114 EESNQEFMVKSEELYDSLMNCHWQPLDTVHSEIP 147 human
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