pfam17451: Glyco_hyd_101C (This model is not part of the current CDD release)
Glycosyl hydrolase 101 beta sandwich domain
Virulence of pathogenic organisms such as the Gram-positive Streptococcus pneumoniae is largely determined by the ability to degrade host glycoproteins and to metabolise the resultant carbohydrates. This family is the enzymatic region, EC:3.2.1.97, of the cell surface proteins that specifically cleave Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins. This reaction is catalyzed by Asp as the catalytic nucleophile-base and Glu as the catalytic proton donor. This domain represents C-terminal the beta sandwich domain.
Jiyao W et al.(2023). "The conserved domain database in 2023.",