7MQ8,7AJT,6RXV


Conserved Protein Domain Family
Nrap_D6

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pfam17407: Nrap_D6 (This model is not part of the current CDD release)
Nrap protein domain 6
Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.
Statistics
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PSSM-Id: 522828
Aligned: 128 rows
Threshold Bit Score: 70.0391
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7MQ8_NH      1005 LDIYDVLIRLSPRHIPR-----HRQA--------------------------VDSPA-ASFCRGLLSQPGP--------- 1043 human
XP_004995438 1195 LAAYDVVFDIAPEAHVRrtqalTGTDddtl-------------------sssSSGGVsKPKFKNLELKGKV--------- 1246
XP_044387716  904 LSNYDAVILLHKEKLCR------------------------------------------------PHHVLFpaeipngkl 935 
XP_003516574  906 LNNYDAVIFLHKDKLPY------------------------------------------------PQRLLFpsevnhgth 937 
Q0WVM5        906 LNNYDAVILLHRDKLPY------------------------------------------------PRRLLFpselnqgkh 937  thale cress
XP_004232410  906 LSNYDAVVLLHRDKLPY------------------------------------------------PQHLLFpseleqerc 937 
4_pfamImport    1 LDVYDVLIRLNPRHIPR-----HREAvd-----------------------lPAAS------------------------ 28  
Q295U7       1025 SEGYDLVIQLKSDLVPN-----ALSYdlgspfvs----------fdqpnyllPRAG------------------------ 1065 Drosophila ps...
XP_067747077  981 RKEFDAMLQLATENLPTkrirvDGD---------------------------KKHPFvAPVYKNMDLTSV---------- 1023
XP_003290102 1060 LFDFDAIFNLNEQLIPNhskeiLNIInnkkfnllsylntnsngtnnnnnnisNTSTSkKPVFKNIIKKSDNnnnnnnnnd 1139
7MQ8_NH      1044 ----------------------------SSLMPvlGYDPPQLYLTQLREAFGDLALFFYDQHGGEVIGVLWKP-TsFQPQ 1094 human
XP_004995438 1247 ----------------------------GTGRP--GWDPVAQLFADLQRQFKDTVMFWYDELGGPVICAAVNP-KvKQPH 1295
XP_044387716  936 viqgkpsndfhpymplsksvvrslhdtrDKLLV--NFDPTAYFLRDLKCAFPVTFKLWHDSIGGDAIGLTWES------- 1006
XP_003516574  938 vaegqaskc-fqpfllpkdlkgrpeelrNKLLV--DFDPSKCFIRDLKQEFSTTFQVWHDYLGGDVIGLTWGE---SYPS 1011
Q0WVM5        938 vargkasrl-fnpfmspgdlkrsheelkNKLMV--DFEPTKCLLSGLQEEFG-TLKPWYDHIGGDAIGLTWNK---HNSK 1010 thale cress
XP_004232410  938 vvrghaski-fhpffsprdfkvnsgelkSKLMV--NFDPVRCFIADIEKGFPDVVKVWYDAVGGDALGLTLGK-As---- 1009
4_pfamImport   29 --------------------------------------------------FSRGLLQSADS--SPRLPVLCYD------- 49  
Q295U7       1066 ------------------------------------KDPLAAIVHQLRSAYSDYAAFFYNPHGGKELAIMWRPpAvFAPK 1109 Drosophila ps...
XP_067747077 1024 -----------------------------PVMI--GFDPVQELLQDLQRSFGHLAFFFVNGVDTTEILITWKP-QaFLPT 1071
XP_003290102 1140 snq--------------lnngnnnnliyKDFKP--GFNPVVELINQLKDKFSEYCIFQYDLVGGNKITLKWKS-QaFLPV 1202
7MQ8_NH      1095 PFKa------sSTKGR--MVMSRGGE----------LVmVPNVEAILEDFAVLGEGLVQTV 1137 human
XP_004995438 1296 PFKmtqtaatrMEKDG--------------------QL-VFDMESFVAECMQLGTGVLSKA 1335
XP_044387716 1007 SKKr------gRDEDD--------------------EA-MPDPTSILKEVGDVGKGLVRSV 1040
XP_003516574 1012 KKRk------hEEVVV--------------------EE-EYNPCKVLKAVGEVGKGFVKSI 1045
Q0WVM5       1011 KREr------dEEEEE--------------------EE-ESNPMEMLKAVGEMGKGLVRDI 1044 thale cress
XP_004232410 1010 SQKr------kHDDSA--------------------EE-STDLLNTLKTIGEVGKGLVRSI 1043
4_pfamImport   50 -----------P------------------------------PSLYLDQLRSPQSSLC--V 67  
Q295U7       1110 AFKvtelqac--------------------tlcdkgKV-QVVRETLVEDFKVLLKDFYLRI 1149 Drosophila pseudoobscura pseudoo...
XP_067747077 1072 KFRa------iTASYQipLPNTDAAEddldnestrsYA-VPNIFEIMSDMQSISHGMVVGV 1125
XP_003290102 1203 PFK--------PSKSKyvTPISKDSN----------LV-IPNIFEILNEIQMLGGKLIKSF 1244
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