6RXV,7AJT,7MQ8


Conserved Protein Domain Family
Nrap_D4

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pfam17405: Nrap_D4 (This model is not part of the current CDD release)
Nrap protein nucleotidyltransferase domain 4
Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.
Statistics
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PSSM-Id: 522826
Aligned: 127 rows
Threshold Bit Score: 120.404
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6RXV_UV       622 FYGRSL------P-ALLSIKPSDTALFNVARKTFTSFERDLRDLeDLPLRIRHVNPICPELRHSSLKTPSF--------- 685  Thermochaetoi...
XP_005803560  638 VDDVIT--------TGNEVPSTGEEESLVVVQSYDDLSRKLWKLeGLPLSITAVQGAHPALRYTQVFPPEPvrldysffe 709 
XP_003470881  641 LDALIQ--------RPKEPSSTGEEALTVAVCCYDDLSRLLWGLeGLPLTVSAVQGAHPVLRYTEVFPPAPvrpafsfhe 712 
XP_002189235  627 LESVIR--------TGKEAGGTGEEAMVSVVCSYDDLSRKLWNLkELPLTVTAVQGVHPALRYTDVFPPIPmkpiysfhn 698 
XP_008117371  631 LESVIK--------MGREPAGTGEEAMVSLIRSYDDLSRKLWNLeGLPLTVTSVQGAHPALRYTDVFPPVPvnpdyayha 702 
Q5M7P5        639 LDCVLT--------RGKE-AGTEEEKMVGIIQSYDDLSRKLWNLtDLPLTVTSVQGTHPCLRYSDVFPPLPvkpdwssyq 709  tropical claw...
4_pfamImport    2 IEEIIS--------LPWKQLSSGNYVVSMAIRSYNEICHKIRELhSLPLSITSIQG-GPILRNTEVYPTPPfqttrient 72  
XP_002117055  595 LDHTLAityedeKsKLPFCNNNATEDAISIIKSFNELCKQLRLLkGLSLSINTIQGISPVFRHTELFPSKPakrfksrtr 674 
7MQ8_NH       641 LDALIQ------G-L-KETSSTGEEALVAAVRCYDDLSRLLWGLeGLPLTVSAVQGAHPVLRYTEVFPPTPvrpafsfye 712  human
XP_056659885  619 LDPLIR--------APKEAHSTGEEALAMVVRSYDHLSRQLWSLkGLPLTVSSVQGAHAALRYTAVFSPVPvhpdfafhd 690  gray short-ta...
6RXV_UV       686 --------------------GPSKSGPRPMEVVISFEASGKWPESLIAIQRTKIAFLLMIGRLLErfkpgeirthvgldd 745  Thermochaetoi...
XP_005803560  710 re-------ktcrflvpkegKPCPHYLTPITVICHMEGSGKWPHDRTAIRHIRAAFHISLAEMLKkhhn----------- 771 
XP_003470881  713 hl-------qerglllprsdKPCPAYVEPMTVVCHLEGSGHWPQDAEAVQRVRAAFQLRLAELLTqqhg----------- 774 
XP_002189235  699 r---------skhfllpsgeKPCPAYITPLRIICHMEGSGQWPQDKGAIKRIKAAFHLQLAELLRqqhq----------- 758 
XP_008117371  703 ri-------kdcesllplaeKPCPAYIAPMKVLCHMEGSGQWPQDKEAIKRIKAAFQLQLAELLKqqhq----------- 764 
Q5M7P5        710 ll-------rekkclvpnpeKPCPAYVAPVKVICHMEGSGKWPQDKDAIKRVKAAFQIRLAELLRaqhq----------- 771  tropical claw...
4_pfamImport   73 iei------agvkreipvpgQPCAPFRKPIEIVCHLEGSGAWPQEAGALRRLKAAFHVSMCEALKssf------------ 134 
XP_002117055  675 lsddvqfrnvaknvllptanKTCPEWIPANEAVCSMELSGDWPQNAEAVQRVKSALHLEIARLLSqhys----------- 743 
7MQ8_NH       713 tl-------rerssllprldKPCPAYVEPMTVVCHLEGSGQWPQDAEAVQRVRAAFQLRLAELLTqqhgl---------- 775  human
XP_056659885  691 ll-------dkrkallprpsKPCPAFVDPINVVCHLEGSGQWPQEADAIQRVRAAFQLRLAEVLSqehg----------- 752  gray short-ta...
6RXV_UV       746 aryetENLAFLDVIYasGACFRVRIQADLEESLLERQTKDKTTEQYLRQRAstqlAS-FRRTFVHLPLHTQYITT 819  Thermochaetoides t...
XP_005803560  772 -ytclPCPTHLDVWKd-GLVFRIQVAYHREPQVLRESVNAEGLLVVRDNEE----AQvLEMATIHKPLLTSTLHG 840 
XP_003470881  775 -lqcrATATHTDVLKd-GFVFRIRVAYQREPQILREVQSPEGMISLRDTPA----SLrLERDTKHLPLLTSALHG 843 
XP_002189235  759 -lvcrPAVTHTDVYKd-GYVFRLQVAYHREPLILKEVVTPEGMWKYQDTEE----SRqLELETLHLPYLTSSLHG 827 
XP_008117371  765 -llcrPAPTHTDVFKd-GYVFRLQVAYHREPQILKEVVTPEGMLKYQDNPE----SQqLELETQHLPFLTSSLHG 833 
Q5M7P5        772 -llcnPSATHTDVYKd-GYVFRVQVAYHREPQYMKEIVTPEGMLKYQDTEE----SLqLELETLHLPSLTSTLHG 840  tropical clawed frog
4_pfamImport  135 --tcvACQDHFDVIKd-GFVFRISVAYHREVAVMQTQRTDDGMIKMVNTAE----SIeLEKRILKLPQLASALHG 202 
XP_002117055  744 -llavGQTNYIDVFKd-GYVFRVRVAYHREPGLIR----------LVENEGnellAAeLEKTTILLPQFATMING 806 
7MQ8_NH       776 --qcratATHTDVLKd-GFVFRIRVAYQREPQILKEVQSPEGMISLRDTAAs---LR-LERDTRQLPLLTSALHG 843  human
XP_056659885  753 -llcsAKASHTDVYKd-GYVFRIRVAYHREPQILKESCTPGGMITLRETPA----SLlLDRDTRQLPQLTSALHG 821  gray short-tailed ...
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