7AJT,6RXV,7MQ8


Conserved Protein Domain Family
Nrap_D3

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pfam17404: Nrap_D3 (This model is not part of the current CDD release)
Nrap protein domain 3
Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.
Statistics
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PSSM-Id: 522825
Aligned: 128 rows
Threshold Bit Score: 106.956
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7AJT_UV       519 DNLKYDLCYDVQLPlgky------nnlEt-SLAATFGSMERVKFIT-LENFLAHKITNVARYALGDRI-KYIQIE----- 584  Saccharomyces...
XP_011389749  671 APFTFDEVARVNLAlstarasskvnsnSngAGLSASSRIQRADFGT-SFQAAMIQVSTTASRALEGRA-KLVALLhr--- 745 
8_pfamImport    1 APFTFDEVARIDLPlstk------areSngVGISAASPIQRADFGN-SFQAAMIQVSSTASRALEGRA-KLVALMhp--- 69  
XP_001731196  518 PLQRFDETASMHLN-----------------LHARGSLVHRLDAGS-PSLWAIRRVLDVSGHALGRRA-RVVAICt---- 574 
XP_018740849  523 LAQRFDEVVLCHVR------------------DDMADVVRRLDAGG-ARAWGIRRALDVAARALGQRA-QGLAVC----- 577 
XP_007875346  437 IPLQFDCYYKVFIPqnw-------eelSk---------dYLHEVSL-KETSFILKLIDIIKKAVGNRIlQITSIV----- 494 
2_pfamImport    1 FLQQFDHLINFNDIkv----------iKd-IVCQHGDKKFKLDLRGdLALQFQQIIEPLLLSSLGDRI-TEMC------- 61  
1_pfamImport    1 IFAQYDHYARLQVDm------------ShlKNLTGEFAIDAVDSSD-VITHFIRDFELKIQKTMEERY-EFVGIH----- 61  
Q54EN2        562 FYQEYDMIISIKIN-------------KqlLANQQSLKVPTNDYYQ-QDTYLNYRIYQLIKKSLTKRV-TKINIL----- 621  Dictyostelium...
XP_003290102  560 FYTEYDLVLKIILG----------------KEELSQFEVPLNDYYQ-KESYLENRIYQLLRKSLTKRV-TKVTIFkhdnd 621 
7AJT_UV       585 -----MVgqkS--DFPIT-------KRKVysn---tggNHFNFDFVRVKLIVNPSECDKLVTKGPaHseTmsTEAAVFKN 647  Saccharomyces...
XP_011389749  746 ------------------------aTGGLastwrldgaRPAASSQAEIGLVLNGEQAWRMVEHGPsSqdV--EKAEQFRA 799 
8_pfamImport   70 ------------------------aTGGLagtwrlngsRPAALSDAEIGVVLDGEQAWRMVEHGPsSqeT--EQAERFRA 123 
XP_001731196  575 ------------------------nPQKTctteqqasgGSASPKIVELGMWLNAEHAWHQVEHGPsPd-S--PDAAAFRA 627 
XP_018740849  578 ---------------------------AApsqayapgaAPALSLHLELGLLLDADHAWHQVEHGPpPe-S--PEAAQFRA 627 
XP_007875346  495 -----HSn-dI--IWNID-------TEFP---------SNIISNEIYIGILIDQENSQKIVERGPsPqdI--NATKEFQQ 548 
2_pfamImport   62 --------------FNVFqdpvvvgKTQ------------EPFSNFLIGLKLNTQKAYSVVERGPiAn-L--PEAKEFRS 112 
1_pfamImport   62 -----EIe-qIanSWNTSdyaasveLKT-----------------FIVGFRSTS-SWKSPLTVGPpAq-T--DKAREFRD 114 
Q54EN2        622 -------------------------KINDddqenendgDDDDEIKIIIGLKVNSENWLSVIDLGPpAd-H--VNASKFRE 673  Dictyostelium...
XP_003290102  622 eytcwKDe--------------------M---------PENVDRTLTVGIKVNTENWLSVIDLGPpAd-H--VNSAKFRE 669 
7AJT_UV       648 FWGIKSSLRRFKDGSITHCCVWSTSSSEp---iI--SSIVNFALQKHVS 691  Saccharomyces cerevisiae S288C
XP_011389749  800 FWGKMSELRRFKDGRVLESVVWPVTTQSsr--wAipRRILSYAMFRHHA 846 
8_pfamImport  124 FWGKMSELRRFKDGRVLESVVWPVTTQAsr--wAipRRILSYVLYRHHA 170 
XP_001731196  628 FWGSVAELRRFRDGRVRESIVWPVSTLAqr--qSipRQIVRYALTQHAC 674 
XP_018740849  628 FWGDAAELRRFRDGRVLESVVWPVASLAqr--yGlpRHVLRHAFMHHRI 674 
XP_007875346  549 FWGKKSELRRFKDGNILESVVWNVENKL-----WliKDIIKFAVNRYVG 592 
2_pfamImport  113 FWGEKSQLRRFKDGDVCEAVVWSDNKVAiskkrCiiRDIVHYVFFHKLS 161 
1_pfamImport  115 LWKGSSELRKFADTRICECVVWAEQPSD-----KvpHAILQFVLKNMYE 158 
Q54EN2        674 FWGNKSQIRRFKDGSILEAVTWNPKNGSr---hLviEEIIKYTLNYHLQ 719  Dictyostelium discoideum AX4
XP_003290102  670 FWGAKSQVRRFKDGSILDAVTWSPKNGSr---hLviEEIVKYILNLHLK 715 
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