6RXV,7AJT,7MQ8


Conserved Protein Domain Family
Nrap_D2

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pfam17403: Nrap_D2 (This model is not part of the current CDD release)
Nrap protein PAP/OAS-like domain
Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.
Statistics
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PSSM-Id: 522824
Aligned: 128 rows
Threshold Bit Score: 76.4675
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6RXV_UV       295 AFRNACILGRIWLQQRGFG-SdvS--K----G-GFGYFEWAVLLALLLQGGPAd------------tKGAAPLSPSLSST 354  Thermochaetoi...
1_pfamImport    1 TARLAISLVQNLFENRHLS--------------IFSTVILPARVFRLI--------------------SQGQITEKQEIL 46  
EGT38748      246 TARLALFLLRSAIENRHLG------------D-TFTPVVLTVRVVRLI--------------------KNGQITEKQEIL 292 
GAA99664      340 AFKDACLLLKVWAHQQHVT-------------------------------YAHndpcpsacwrtaerQGYKKLPKTASSW 388 
ESK98055      309 AFNDAVSLLRVWANQHGYGeG--T--RmcvrGfDGKGPWWTSLLALLISGEESsspg------kgksSKRKPLGRGLSSY 378 
3_pfamImport    1 AFQDAVMLLRVWANQRGYGeG--S--QlcvrGfEGKGFWWAALLGLLILGEEPsstg-------ktnVRQKPLGRGLSSY 69  
XP_007331513  363 GFGDAVTLLRIWGNQRGFApG--SqdKlcvfGfEGRGALWSAVASLAVLGEEQqkkna-----snvfGRRRALGRGLSSY 435 
XP_001883057  353 AFADALTLLRIWANQRGFSeG--S--RfcvrGfEGSGPFWVGLLALLMKGEEPrasd-------skyTKRRPLGKGLSSY 421 
XP_009268618  302 AFRDAVKLLKIWSNQRALEw-------------FLEGFNAEFLVALLVEGDQ---------------HGSKRVGKGLSSY 353 
XP_006959060  314 AFRDAVKLLKVWANQRSLDw-------------LLNGFNAEFVVALLVDGDQ---------------DGKGRVGKGLSSY 365  Wallemia mell...
6RXV_UV       355 QLFKALIQFLSVTNFAE-KPCVLgq---aKPDLaGFIEn-gPILWDSARQLNIAFKMGPWSADLLHQHARWTRKLLa--D 427  Thermochaetoi...
1_pfamImport   47 TVLRIIFRDFVSWSIDDvEYVDPegedlsEDVTqEYSEhfdVNLIY--DHLNIAANVTRNHMNRMKEELSTCLPLL---- 120 
EGT38748      293 TVLKVIFKDFINWSTDEvEYLDIeeeqldDELEeEYSQhfdVNLIW--KHLNIAGNLTKNQMARMKKELSTCYPLL---- 366 
GAA99664      389 QLFSAVIDFLAETSLAR-RLVFAksd-tpLFSPdELSAaymNGFIDHTGSRNLLAGIPSANLDALQFASRMSAIAIa-mD 465 
ESK98055      379 QLFKAALDFLSKHDFEN-DPIYIktkdghRYLPdEYQShheAVFVDPTSTFNLLANVPIGSLKLLQHDAKRTLELLn--s 455 
3_pfamImport   70 QLFKAALYFLSRHEFSK-SAIFVksseghTFPPeEYVHhhsAVFVDSSSRVNILANVPLGSLELLRHDARKTLEILdhpT 148 
XP_007331513  436 QMFKAALDFLSKADFEK-EAIFVktangqRFPPdEYNSqeqPTFVDSTSLVNLLSGVPRGSLELLRYEALDTLETLn-qT 513 
XP_001883057  422 QLFKAALDCLAKHPFGK-SPLFVkakdghRFPPeEYEGh-eAVLVDSGSFVNLLSGVPLGSVKLLQYEASKTLEILn-eT 498 
XP_009268618  354 QLFKAVMDLIAQTDF---SNVFIkstsasGFSQeDFVGsstLLFVDPTRTFNFMDGLLPEDVQVMAFEAKMTLDALs--D 428 
XP_006959060  366 QLFKTVMDLLRKTDF---TSVFMksittgGFSKeDHFNstpLLFIDPTHTYNLMDGLLPEDARVIGFEAQLTLNALd--D 440  Wallemia mell...
6RXV_UV       428 G-AVDQFQPTFILK 440  Thermochaetoides thermophila DSM 1495
1_pfamImport  121 G-QVYTFDGVFIEK 133 
EGT38748      367 G-QVYTFDPIFIEK 379 
GAA99664      466 --PSAAFSSVLLRS 477 
ESK98055      456 EaLTDPFPQVFLKD 469 
3_pfamImport  149 StSDDPFTQVFLRE 162 
XP_007331513  514 TiSSESFNKVFLKD 527 
XP_001883057  499 TiTGDPFTEVFLKD 512 
XP_009268618  429 --ESDRFEETFMRD 440 
XP_006959060  441 --DNDRFEDTFMKD 452  Wallemia mellicola CBS 633.66
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