Conserved Protein Domain Family
STD1

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pfam17235: STD1 (This model is not part of the current CDD release)
STD1/MTH1
This family of proteins includes the known homologues STD1 (also known as MSN3) and MTH1. Both STD1 and MTH1 are involved in modulating the expression of glucose-regulated genes in yeast, but have been shown to function by slightly different methods. It has been suggested that both STD1 and MTH1 are required to repress the hexose transporter genes in low glucose conditions. STD1 has also been shown to stimulate SNF1 kinase through interaction with the catalytic domain of SNF1, antagonising auto-inhibition and promoting an active conformation of the kinase.
Statistics
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PSSM-Id: 522771
Aligned: 38 rows
Threshold Bit Score: 128.631
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDK44782      96 SSLTnn-------gkRSIRSAPSIYSSStatipedfePITTTVEQLI-----------NDIALHEQHFErefeakkq--- 154
Q6CY44         7 SALFsie------dgTTESVTPKYGHGVqe------dDIDLQLRALIycyqrlkvkemSPFYPVDSTTEdgetlg----- 69  Kluyveromyces l...
XP_011273530   5 KSLWpns-------stNVITIPQHIEGEle------dDLDLKIKSLTylfkrlnienlPAFINDENGIydlrndeann-- 69 
XP_002494097   6 SWGGtessqeqkhirNAIHNIPNYLEGEne------dPIDLQVKSLTyvfkrlkadrwGPFLQADESNgygysmkvdnt- 78 
XP_013935064   3 RYFWsrn--------evAVNVPRYQGGEne------dSVDLQIKSLMymferlkiynfAPFLKi---lDsgevsfdwlsk 65 
XP_001384898   5 NLFSsgs----------raTIPRFHQDEnh------dSIDLQIKSLLylfkrcqiaklAHFLNSDGSFrynesgsgsvnf 68 
Q6BMY6         5 SLFGtsa--------nkTAKVPNFEQGEnh------dSVDLQVKSLLyvfkrlrlnklSSFLGKDGTTysfkyvdgdkql 70  Debaryomyces ha...
XP_036663577   5 NAFIald----------stSIPTFDPSId--------SINLQVKSLLylfkrlrinklLPLLKNGELTytdslvgdr--- 63 
XP_002547586   5 DLLSfssss--sstsTSSSIIPTYDQNQd--------SINLQIKSLLylfkrlqidklSTLPNKDGTLryivkknelv-- 72 
XP_002493686  59 NDQKsle------ssNSLDT--HHYYNNislpplrpsLRHFMISRVL-----------EDLSQEISFS------------ 107
EDK44782     155 -------realplynSPTFDPDETFKISLGsgLTFQndlqSnfLIDWNLNVTRCKLILINLpmis----sastTQQqlcy 223
Q6CY44        70 ---------dgsvalDKVYNLEQFIAMLQEd--------pHhiLVDWCKNKARLMCILSSTpvrtvn------------- 119 Kluyveromyces l...
XP_011273530  70 ------edtyyntklDTIYNKIEFERVLINd--------eHriLVDWFKNRFRSICILSNYpsksnl------------- 122
XP_002494097  79 ----lssgnygndklDVIYNIKRFEEKLFTd--------eHriLIDFPKNKMRSLLILSDNtdssiipslgkeN------ 140
XP_013935064  66 pdapihpdviindklDSVYDIQSFKKILLDd--------pYriLIDYCKNKFRSYLILSDSpkefs--elpkfMAPd--- 132
XP_001384898  69 ----gqeestyyqklDQVYNIEGFKHSLIKd--------eYrvMVDFCKNKFRSFCIVSDLps----------------- 119
Q6BMY6        71 n--sdsgvhnyfqklDAMYNVKKFKQVMINd--------eYrvMIDFTKNKFRSFCILSEYpskgtlssqgigNGEfpnf 140 Debaryomyces ha...
XP_036663577  64 -------sdptfaklDKTYNVIRFKEMLLDd--------eYrvLVDFIKNKFRSMCFIDDLpt----------------- 111
XP_002547586  73 -----vdddptfnklDKIYDVDKFLNILLNd--------eYriLVDFIKNKFRSMCMIVEYps----------------- 122
XP_002493686 108 ---------------NNIDNLGLLVYSQLNslNLTD-------VLDWKLNTVRCLLLLSEIphcwankmdhhsIPPirls 165
EDK44782     224 NQHYPPQLV---------------GDLAKv---------------------------------VQLIIIQP--HITDKEL 253
Q6CY44       120 ----------------------------------------------------------klpkgFSYLILEP--DSSEDLY 139 Kluyveromyces l...
XP_011273530 123 ---------------------------------------------------------nslgkhFKFIVLKP--DSSDEDY 143
XP_002494097 141 ---------------------------------------------------------------FQFHVLKP--NGSDEEY 155
XP_013935064 133 ---------------------------------------------------------------FQFTILKA--NSSDKNY 147
XP_001384898 120 ----------------------anLSRPNspvkgagineesgd------fpsfrdskdrkvrhFRFVLLPLe-GLTVEFV 170
Q6BMY6       141 kdy-----------------------------------------------------kdrdvkhFRFSIIPLq-DTSIAFI 166 Debaryomyces ha...
XP_036663577 112 -----------------------nLSRPRsptrnsstdavsavdvdddflppfldykerntklFKFTLFSIsqPHTTESI 168
XP_002547586 123 ----------------------nlSSRPSspikgqstnnptmif----pdfkdykdrnmngknFKFVLFPLn-DVSIDKI 175
XP_002493686 166 SSHASKDTVipeiykseiikvqekTPHTQfsrivrrki-----------------qgdldspvFELKLLPP--NPTDSEF 226
EDK44782     254 IFTLV-QSNIYKEH--NLDLAFRKSVAEILVKQSRLLQINSlrqntnselqhnlsintnvlnehHDFLKFKYKEIaVRNY 330
Q6CY44       140 FQRLVyDSKLYHEH--DVPLSWKIQCLREIIKKQYTLVPTRr----------------------KSFNKQDRWQI-MIRY 194 Kluyveromyces l...
XP_011273530 144 LKILI-NSDIYYEH--PIDPILKTDILLEILKNQKLLKPSYk----------------------KNFNKNDRSII-ILKY 197
XP_002494097 156 YSVLIeKSNIYEEH--QVSYRTKSSILGSAIRYLDGMKPR------------------------DEFTKDDRAWI-IRQY 208
XP_013935064 148 IDVLVnKSDIYKEH--NISQRVKTDIAREIIAAQRACSND------------------------KVFDKNDRAKI-IRFY 200
XP_001384898 171 ANTLS-GSDIYHEHfsYMDFSSRHQNAIDSIKKVIRDDRIDmksp----------------akeFSISENEKAAI-IREY 232
Q6BMY6       167 ANTLS-TSDIYVEHhnKIDFNCRYQYAMDSINKVLDMERSMsdi-----------------dssISITDAEKASI-IQYY 227 Debaryomyces ha...
XP_036663577 169 ASILS-GSNIYIEH--KVPFLKRYNIALTATNKVIGKPLTTk----------------------FTIDQKQKLKI-IRNY 222
XP_002547586 176 AQILV-NSDIYIEH--KVSYSKRYSIALESIKSVISINQ-------------------------KRITINEKNQI-IRNY 226
XP_002493686 227 VDFLV-HSNLYKEF--KLESSFKRQVAMVSVSKARKLQTETehs------------------dpDESLGLIYLAIgLQNY 285
EDK44782     331 LINLAAAATTAHEYKLRVDEIK 352
Q6CY44       195 LSKLAEHVQIERVYKAYRSQPP 216 Kluyveromyces lactis
XP_011273530 198 VRKLSEIIQIERIYKASLLTKL 219
XP_002494097 209 VNKLAIHVQTQRIYRESKRQAS 230
XP_013935064 201 VQKLAYHIQVERIYKATLKSKE 222
XP_001384898 233 LIAVAFNVQVMRIYEEYIKHHP 254
Q6BMY6       228 LKRVAFFIQLNRIYVEYLKHHA 249 Debaryomyces hansenii
XP_036663577 223 LTLLATHVQVMRIYHEYTKMHP 244
XP_002547586 227 LIKLSFHVQLLRIYQEYIKLNS 248
XP_002493686 286 FLNILVASLTLFEFHYAVCEIL 307
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