6L53


Conserved Protein Domain Family
SMG1_N
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pfam17229: SMG1_N (This model is not part of the current CDD release)
Serine/threonine-protein kinase SMG1 N-terminal
This entry represents the N-terminal disordered region of SMG1, which is a member of the phosphoinositide 3 kinase-like kinase (PIKK) family. SMG1 associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. It also plays an important role in genotoxic stress responses to DNA damage.
Links
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Statistics
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PSSM-Id: 522769
Aligned: 8 rows
Threshold Bit Score: 166.937
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6L53_A         32 TDSASADPDNLKYSSSRDRGGSSSYGLQPSNSAVvSRQRHDDTRVHADIqNDEKGGYSVNGGSGENTYGRKSLGQELRVN 111  human
C5J7W8         27 SDSLSASQDGVKCSVSRDRGSEVLFEILPSDRPG-TPPLHNDAFTATDA-LEEGGGYDADGGLSENAYGWKSLGQELRIN 104  zebrafish
1_pfamImport    1 GDGVSSLQDKLK---SRELGSGPSYDVLPPRCPE-QPPLHSDAYGAADA-HQEEAGYEVEPGVCDTAFGWKSLGEELRPN 75  
6_pfamImport    1 VNSVSSSQDEVK---SREFGSGPLYDVLASSCPE-QPAVPSNVYAAADA-HQEEGGYEAGQGVCDTTFDWKSLGQELRPD 75  
4_pfamImport    1 VDSVSSSPDGVK---SRELGSAAAYDVLPCSYPE-QPAEPRDAHAPADD-HQEEDGYDVGHGVSDTTFGWKSVGQELRTN 75  
3_pfamImport    1 GDSVSASQERLKCSASGDHAPGTLVDAAPADSPG-TAPLHNEVFAASDA-LDEGGGYEVDGGACENTFGWKSLGQELRLN 78  
XP_069036868   27 GDGASASPDGVKRGAPREHGPEAPPDSQPFGAPG-SPPQCDEASAASDG-LEEEGGYEVNGGLGESAFGRKSLGQELRRN 104 
XP_064415220   28 SDSASADQDNLKYSVSRDRGSSASYGLQPSNSTVvSRQRHEGIQVLADAqNEEGGGFDVNGGLGENAYGRKSLGQELRVN 107  coelacanth

6L53_A        112 NVTSpEFTSVQHGSRALATKDMRKSQERS 140  human
C5J7W8        105 DVTT-DITTFQHGNRALATKDMRKSQDRP 132  zebrafish
1_pfamImport   76 DVTS-DLTTFQHGNRALASKEMRKSQDRG 103 
6_pfamImport   76 DLTT-DLIPFKHGNRALASKDMRKSQDRG 103 
4_pfamImport   76 DVTT-DLTPFQHGNRALASKDMRKLQDRG 103 
3_pfamImport   79 DVTS-DLTSFQHGNRASASKDMRKSQDRP 106 
XP_069036868  105 DVTA-DLTSFQHGNRALATKDMRKSQDRL 132 
XP_064415220  108 NVTL-DSTSVQHGNRALATKDMRKSQERP 135  coelacanth
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