pfam17214: KH_TffA (This model is not part of the current CDD release)
Transcription termination factor FttA, KH domain
This entry represents the KH domain found at the N terminus of transcription termination factor FttA and similar archaeal proteins. FttA is a single-stranded endoribonuclease (endoRNase) that mediates cleavage at the RNA exit channel of RNA polymerase (RNAP); the 5'-3' exonuclease activity of this protein degrades the nascent RNA released from RNAP. It terminates transcription on the whole genome, a process that is linked to FttA-mediated RNA cleavage and does not require NTP hydrolyzis. It also has weak activity 5'-3' exodeoxyribonuclease activity on ssDNA.
Jiyao W et al.(2023). "The conserved domain database in 2023.",