Conserved Protein Domain Family
DUF5134

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pfam17197: DUF5134 (This model is not part of the current CDD release)
Domain of unknown function (DUF5134)
Proteins in this family are uncharacterized, but have been identified as members of a gene cluster for the synthesis of the tetramic-acid antibiotic streptolydigin, which inhibits bacterial RNA polymerase (RNAP).
Statistics
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PSSM-Id: 522751
Aligned: 40 rows
Threshold Bit Score: 40.9188
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_014361105  34 EAYVGHVLHLVMSVAMLVMAWPFSADWPTAGP----MWFFVVAAAWFLVSLAlhprlrptddcgcvpptttpFGRLAAVY 109 Gordonia polyis...
4_pfamImport   1 GERATARAEAVMAFGMAAMALPAAVLTPPRWAwtvyAVVFGAAALRALTGAR---------------------SGGHHVH 59 
2_pfamImport   1 PGRKAAGGEALMGLGMAAMAVPATLFTLPRWHwmvyAVVFGAAAVHAVRPAG---------------------NGGRHLH 59 
WP_003958538  32 PGRRAGVEDGLMGLGMAAMALPAVMDA----AgpvyAVVFGGAAVHALWSAR--------------------HGPAGHLH 87  Streptomyces cl...
WP_015031938  32 EERRAAGGEAVMGFGMATMALPAAVLTPPGWSwgvyAAVFGGAALHGLVALR---------------------HGGRHAH 90  Streptomyces
1_pfamImport   1 EQRRAAGGEALMGFGMAAMAVPAAAVAPPRWAwlayAVVFGTAAVRALWSAR---------------------TSAHHLH 59 
WP_043446498  32 EQRRAAGGEALMGFGMAVMAVPAAVAVPPSWAwtacAAVFGAAALRALWAAR---------------------TDAHHLH 90  Streptomyces no...
WP_044379374  32 EQRREAGGEALMGFGMAAMAVPPAVFSPPPWTwalyAAVFGAAGLRALWAAR---------------------DRPHHLH 90  Streptomyces cy...
WP_023552770  32 EQRRSAGGEALMGFGMAVMAVPAAVFTPPRWAwpvyAAVFGAAALHALWAAR---------------------AAPRHLH 90  Streptomyces ro...
WP_040255358  32 AQRRAAGAEAVMGAGMAAMAVPASVLSPGRGAwscaALVFAVLALRHAWSAR---------------------RERHHLH 90  Streptomyces ph...
WP_014361105 110 HATMMGAMAWMYAVMngivlpggpttqamamgSPGPSVTVLAHNHDdmPGMnmpgmdvghhaaqpgyVTPVNWILTIGFA 189 Gordonia polyis...
4_pfamImport  60 HLVGSLAMVYMAVAMapg-----------lagAAHEGHTAHAA-----AGG----------------VPLLTGALLAYYA 107
2_pfamImport  60 HAVGCMAMVYMAAAM-----------------AGPGAHGAHT------AGG----------------VPLLTGVLLLYFA 100
WP_003958538  88 HLVGSLAMVYMAVAMt---------------pASASGHAVHTGPPS--AAG----------------IPLVTGALLVYYA 134 Streptomyces cl...
WP_015031938  91 HVVGSLAMVYMAVAMa---------------sPDPGAHTGHTVGT---AGG----------------IPVLTGALLLYYT 136 Streptomyces
1_pfamImport  60 HLVGALAMVHMAASMa---------------aGPGGGHG---------GAG----------------LPLVTGVLLAYFA 99 
WP_043446498  91 HLAETSAMVYMAVTM-----------------GASGGHHAH-------GGG----------------VPALTAVFLLYFA 130 Streptomyces no...
WP_044379374  91 HLVGAGAMVYMAVVMa----------------GSPGPAQGHGHG----GSG----------------AAPLTGALLLYFA 134 Streptomyces cy...
WP_023552770  91 HLVGACAMVYMAAAMa---------------vAPPGPHHAHD------GTG----------------VPLLTGSLLVYFA 133 Streptomyces ro...
WP_040255358  91 HLVGSGAMAYMAVAMa---------------aRPPGAHAAHA------AAG----------------LPYLTGALLLYFT 133 Streptomyces ph...
WP_014361105 190 LAAAVWLYLYFA--------RRRAPgast----------------------dlmtFAGDLCQVFMAVGMAIMFGVM 235 Gordonia polyisopre...
4_pfamImport 108 LYVLRSAGGLIPvtaapagtpva---------------------vgtriawgarpELALACRLTMGIAMFAMLLTL 162
2_pfamImport 101 GYVLRSGLRLVPlapagggpvp------------------------vadpagsrpELVPACRVSMATAMLAMLLAL 152
WP_003958538 135 VYALRAGARLVPsvpvvpaagsg----------------------awgdgtepgaELTSACRLTMALGMLAMLLAL 188 Streptomyces clavul...
WP_015031938 137 AYVLHTGARLAP---------EAIPgatvpvpvgvapapagalggarrpgwatrpELTLSCRLSMALAMLAMLVAL 203 Streptomyces
1_pfamImport 100 GYVLWAGLRLMPvpvpvtagargaa------------------ataaatgwgdrpELARACRLSMGIGMFAMLLTV 157
WP_043446498 131 GYALLSGVRLVPvaavspggsv------------------------rtvgwgdrpELARACRLSMAIAMLAMLMTL 182 Streptomyces nodosus
WP_044379374 135 GYVLLGGARLVPvaavpadgp--------------------------aagwtgrpELARACRLSMGIAMLAMLLTL 184 Streptomyces cyaneo...
WP_023552770 134 GYVLLAGARLVPaavatqgsGSGAVtgvgagtgpgtvtgaggmararaagwgdrpELARACRLSMGIGMVAMLMTM 209 Streptomyces roseoc...
WP_040255358 134 GYVLWSGARLLPaaaavpvsg--------------------------taawgdrpELAQVCRLSMGLGMLAMLLAM 183 Streptomyces physco...
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