Conserved Protein Domain Family
Rit1_C

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pfam17184: Rit1_C (This model is not part of the current CDD release)
Rit1 N-terminal domain
This domain is the N-terminal domain from the enzyme (EC:2.4.2.-) which modifies exclusively the initiator tRNA in position 64 using 5'-phosphoribosyl-1'-pyrophosphate as the modification donor. As the initiator tRNA participates both in the initiation and elongation of translation, the 2'-O-ribosyl phosphate modification discriminates the initiator tRNAs from the elongator tRNAs. The N-terminal domain is the most conserved region of the protein.
Statistics
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PSSM-Id: 522744
Aligned: 103 rows
Threshold Bit Score: 310.656
Created: 19-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001387260  18 LRKDTLSLKNRLQSILYDSKFV-SGLELN---FPLVPNERCGLWYVPNDSQI--DSSYFKSTDGHTSEWAFSMRRLNLHL 91 
XP_002280444  15 IKRKENSLYNALRSIYEDSIFV-GEISQLwpqLPLLANLRCGLWYS--PNFQ--YTCYFKSTDGHTNNCSFNTSRLNFHV 89 
XP_004251633  16 IKRSENTLYNALRSIYEDSIFV-GEIAQLwpeLPLLANLRCGLWYS--MKFH--STCYFKSTDGHTNNWSFNTSRLNLHV 90 
XP_002514212  17 IKRRDNNLYNALKSIYEDSVFV-GEISQLwpdLPLLANLRCGLWYS--PEFY--ATCYFKSTDGHTNNWSFNTSRLNLHV 91 
XP_003285946  12 vFKGELGIFNRLQSIYHDSQFVkRTQESLypgLPLIANLRCGAWYSDKFD----ATVYFKSTDGHFGNWSFSTNRLNLHL 87 
XP_004352453  25 LDRDEHSLLNHLLSIAHDSEFV-DKVANIyqkYALLGNLRCGKWYNKSYD----GYCYFKSTEGHYGQWNFSLTRTNLSV 99 
XP_020436825  22 VDRQENSLFNHLRSIDLDSKFV-NDIALCyskYALVANLRCGAWYSANFK----YSCYFRSTDGHYGNWRFSLTRLNLNI 96 
XP_004990534  50 vTQEGLSIYNRLRSIDADVEFV-DRIAGLysdLPIVANLRCGGWYFPEFD----GEVHFKSADGHRGQWQVSLKRLNLHL 124
EPB81732      21 IRNDNKNIYNRLCSIVDDATFV-MKVADImpsLALIANERCGSWYIDRT-KRkaYSAYFKSTDGHMHIWDFNIRRNNLHL 98 
XP_003524405  24 IKRRENSLYNALRSIYQDSIFV-SEISLLwpqLPLLANLRCGLWYSRPAAFH--STCYFKSTDGHTNNCSFTTARLNLHV 100 soybean
XP_001387260  92 VPIIGE----NDGISIIDSTRKGKL-MPDALSKTIPIWCAVLNSILYEdtsdnei---vqelgslLSGwseddtgfildl 163
XP_002280444  90 ALLAGQ----RGGCIIVDSTRRGKR-FPDSLTKTIPIWTCVLNRAIFNyfnrigesgsgfdadssSYNrngentrhishd 164
XP_004251633  91 ALLAGQ----KGGCMIVDSTRKGKR-FPDSMSKTIPIWTCVLNRAIRNyrtrfglngsaeknesnDCAecgntinedsyn 165
XP_002514212  92 AQLAGQ----KGGCIIVDSTRKGKR-FPDSMSKTIPIWTCVLNRSILNhvkkk--------qeeaDTFnhaenkslgshn 158
XP_003285946  88 LDIIIK----KKAAIIIDSTRKGKN-FPDSFSRTIPIWTCVINRTLLHlkien--------ikrnHQNeasanqlisile 154
XP_004352453 100 IDFILNaprgERGVVIVDSTRRGKK-FPDSFSRTIPIWCCVINRTLYNlkikkdl----ltittsTTTstststtttnil 174
XP_020436825  97 IDLVLK----YDGCLIVDSTKRGKK-FPDSFTRTIPIWIAVINRCLYK-----------------LKSesiqtvmndnli 154
XP_004990534 125 LPLLAE----KGGCVLVDSTRK-ARtLPDSFSRTVPMWCAVMNRLhdil------------ygdcRGDaddsvdhgkvga 187
EPB81732      99 IPILMS----HNGCLIVDSTRKGKR-IPDALSKTIPIWCCTVNRAVATyag--------------------------ytq 147
XP_003524405 101 ALLAGQ----KGGCIIVDSTRRGKR-FPDSMSKTIPIWTSVLNRAIKDfrdsn----------------------gcple 153 soybean
XP_001387260 164 KNNHSWLrtPREMVFRSEHNLIVKRI-PEFVKEVKH---L-GLiskkQLIAaLGGKr-KPLVPF-------WT------Y 224
XP_002280444 165 WDCSLHL---PLWVSKTEKAAIEDRL-EEWTKELEA---S-GA----DIAS-LALSlkKPLRPL-------WI------S 218
XP_004251633 166 WDCSLHL---PLWVSNTERVLIEERL-DGWTKDLEV---S-GA----DIAS-IALSlkKPLRPL-------WI------S 219
XP_002514212 159 WDCSLHL---PLWVPETEKAAIEECL-EAWTKELEV---S-GA----DIAS-IASSlkKPLRPL-------WI------S 212
XP_003285946 155 NRWNSELn-tPNWVPPTEKNQIEKLViNKFVKELLK---C-GA----DLSK-FTESidKPLRPI-------WI------N 211
XP_004352453 175 NQEDWETfsHPMWLSNSEVDQMTCIV-NEYSQKLLLyshI--L----NLES-YATKldKPIKPLfinvdtiWIdnmnesP 246
XP_020436825 155 AEQWNQLy-tPKWVTDSERDQMLKMV-DSYCKLLMEh--AdTL----DLKS-YSSRlhKPLRPL-------WLsv---eT 215
XP_004990534 188 PDWDTQLhcPPTTVPQQELCQMQDLL-DARVHAVLE---S-GV----DLSL-LKNl-rKPLRAT-------WV------T 243
EPB81732     148 DEWDLDLhtLPSAVSRSEHAQIEARL-DGFVDKLLT---S-GV----DMKH-LVSQlkKPLRPI-------WF------T 204
XP_003524405 154 WDCSLHL---PLWVSQTERASIERRL-DEWTLLLKA---S-GA----DIAS-LAAClrKPLRPL-------WI------S 207 soybean
XP_001387260 225 -PgnkGRIHTISNDHNDggivfe--dstvnrTNPYYTIQCVTASKkteELDgapitvqsrsqdQElistswrYIQGAADD 301
XP_002280444 219 -Q---KTVIWLNEVPDCd-------------SWDFTPMILVSASS---STGifqnr---ttseFSw-----kYIPGAGDD 270
XP_004251633 220 -Q---KTVIWLNEVPDCd-------------SWDFTPIILVSTSS---PSSnlqqr---ttseFSw-----rYIAGAGDD 271
XP_002514212 213 -Q---KTVIWLNEVPDHd-------------SWDFTPIILVSASS---ASSiyqhr---ttseYSw-----nYIAGAGDD 264
XP_003285946 212 -T---ESILWTDSIVNPd-------------DLDFHPLYLVSCSDhrreg---------hpsyRS-------YVQGAGDD 258
XP_004352453 247 tT--------------------------------FYPIYLLSASDyrdn----------nrpfRA-------YIQGAGDD 277
XP_020436825 216 qPiilEFEQQQQQQQTSnnnnnnnndddkeeQLDFHPLYLLSCSDfred----------hksfRA-------YIQGAGDD 278
XP_004990534 244 tEtarAHEAASRSDGDTstlel-----ehvdRTKYTAIVCLCASEpvdi-----------eqrRGy-----vYVQGAADD 302
EPB81732     205 -PqsyDALMESPPDFQD---------------ASFCPVVCLSASEavesg---------yqlrPGy-----lYVQGSADD 254
XP_003524405 208 -Q---KTVIWLNEVPHHe-------------SWDFTPIILLSASS---SSSvvgasqhrttseFSw-----nYIPGAGDD 262 soybean
XP_001387260 302 HELWAtkDicqGnLSPKIFWSllLIKsaegiidentgyiyDWLS--EAE-LTQKLNKLYS 358
XP_002280444 271 EESWA--R---G-LSPKVFWN--HAS--------------ELINsgPDL-CNQKVATIVE 307
XP_004251633 272 EESWA--R---G-LSPSLFWK--HAY--------------DLINsgPDT-CNKTVADIVE 308
XP_002514212 265 EESWA--R---G-LSPSLFWS--HAY--------------DIIGsgPDL-CNQKVADIVE 301
XP_003285946 259 EEGWS--Y---G-LTPQLFWS--NCK--------------EILDiqQDC-LEDFISNLLL 295
XP_004352453 278 EENWS--N---K-LSAQLFWT--HKQ--------------DILGqpIDN-VDRYCQELVK 314
XP_020436825 279 DENWS--M---G-LTPQMYWS--NHK--------------EIMSqeNDEqLEQYIQQLVK 316
XP_004990534 303 EETWS--M---G-LTPRLFWQ--HKT--------------DLLDgdSDT-CGDRVRALVS 339
EPB81732     255 EEAWA--L---G-LTHLAFWK--HRH--------------DILTn-sNE-CERNVKSLVA 290
XP_003524405 263 EESWA--R---G-LTPAFFWK--HVY--------------DLINsaPEV-CNQKVADIVE 299 soybean
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