Conserved Protein Domain Family
CAMSAP_CC1
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pfam17095: CAMSAP_CC1 (This model is not part of the current CDD release)
Spectrin-binding region of Ca2+-Calmodulin
CAMSAP_CC1 is the conserved region on calmodulin-regulated spectrin-associated proteins in eukaryotes that binds spectrin. CAMSAPs are vertebrate microtubule-binding proteins, representatives of a family of cytoskeletal proteins that arose in animals. This conserved CC1 region binds to both spectrin and Ca2+/calmodulin in vitro, although the binding of Ca2+/calmodulin inhibited the binding of spectrin. CC1 appears to be a functional region of CAMSAP1 that links spectrin-binding to neurite outgrowth.
Links
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Statistics
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PSSM-Id: 522697
Aligned: 24 rows
Threshold Bit Score: 59.6225
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_015794640   679 PGATSEQVNMQVASQIHNVRLKLEEKRRLIEQERKSAEDMWKAKRQD---------IGKEAFLRVLKS 737 
10_pfamImport    1 TVANDVVDNGIMGSQLMNIRMKLEEKRRRIESEKRRMEAQLNRQRQKditeveqkwLSGDGFTEERKT 68  
11_pfamImport    1 DDVDDNQP-MEDASKISTIKLKLEEKRRLIEQEKRRIESAWSKQLQT---------VGKQAFLQAINK 58  
EDS26757       196 EDADESAPGYEDASKISTIKLKLEEKRRLIEQEKRRMESAWSKQLQT---------VGKQAFLQAINK 254 
EEC02376       568 RGAPERSEEGPLAARLGAVRLKLEERRSKIEREKRRLEERVKRQRQQ---------AGQAAFLQAVGR 626 
5_pfamImport     1 HQGSQGPNAPEPGSEAWELAARLEDKRKSIEAQKRRIEAIFARHRQR---------LGKTAFLQLKRE 59  
XP_008102440   663 PPDESPAQSPALSSEMSQLGARLEEKRRAIEAQKKRIEAIFTRHRQR---------LGKSAFLQLQKA 721 
Q80VC9         586 SPTSTPVAPEALSSEMSELGARLEEKRRAIEAQKRRIEAIFAKHRQR---------LGKSAFLQVQPR 644  house mouse
A1ZAU8         591 DVGDDDMRSLENASKLSTIRMKLEEKRRRIEQDKRKIEMALLRHQEKedlescpdvMKWETMSNESKR 658  fruit fly
XP_028907394   612 GAAGPETLTSEMSSEMSQLGARLEEKRRAIEAQKRRIEAIFAKHRQR---------LGKSAFLQVQRR 670  platypus
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