Conserved Protein Domain Family
QVR

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pfam17064: QVR (This model is not part of the current CDD release)
Quiver family u-PAR/Ly-6-like domain
In Drosophila QUIVER (also known as SLEEPLESS protein or SSS) is a (GPI)-anchored protein required for homoeostatic regulation of sleep under normal conditions and following sleep deprivation. It is a novel potassium channel subunit that modulates the Shaker (Sh) potassium channel which regulates the sleep. Besides the Sh modulation, SSS also antagonises nicotinic acetylcholine receptors (nAChRs) to reduce synaptic transmission and promote sleep.
Statistics
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PSSM-Id: 522691
Aligned: 754 rows
Threshold Bit Score: 28.0744
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ODN06305       24 KCYTCNSA-KDE-----GCSA--SPPPEKYLIECS--HDtmeilndfhrqtkleeaasakhdhghdhddsehghehhrhe 93 
XP_024510885   62 KCYSYINK-MNK-----IEKYfnLTDSPEADVNCYf-ND----------------------------------------- 93 
11_pfamImport   2 KCFSYISG-ISK-----IERYsnLSDSPEINVTCQy-DS----------------------------------------- 33 
4_pfamImport    2 KCYSYVNQ-ISM-----IKRYsnLTNLPETNITCRy-DD----------------------------------------- 33 
GAU92691       64 SCYECSSL-NKQ-----TCSA----PAKEALKDCGagTT----------------------------------------- 92 
GAU92690       24 RCYSCSPQ-ADPskqivQCVT---AADPTTLRDCGntVS----------------------------------------- 58 
EZA57302       25 KCYQCDSQ-TDD-----SCKN---KLETKHEETCSagVD----------------------------------------- 54 
69_pfamImport   1 DCYECISD---K-----NCKD--------STKTCTveNP----------------------------------------- 23 
70_pfamImport   2 KCYQCSNLiNDK-----SCEG---DVKECTTTDIN---P----------------------------------------- 29 
XP_021966819   31 RCYECSSS-WND-----DCTM--SPPPSRYLKLCS--VP----------------------------------------- 59 
ODN06305       94 mesmpaastapaplledpsettqlpdastpaalandrqarsvdanmnepgslitaavklpkeatFCRKNSYHipeqvngp 173
XP_024510885   94 ----------------------------------------------------------------ICIKYTIQi------- 102
11_pfamImport  34 ----------------------------------------------------------------TCVKYAITs------- 42 
4_pfamImport   34 ----------------------------------------------------------------SCVKYTIKi------- 42 
GAU92691       93 ----------------------------------------------------------------ICYKYYSK-------- 100
GAU92690       59 ----------------------------------------------------------------VCFKTRVQvg------ 68 
EZA57302       55 ----------------------------------------------------------------LCFSCAVQl------- 63 
69_pfamImport  24 ----------------------------------------------------------------ACLKFDGT-------- 31 
70_pfamImport  30 ----------------------------------------------------------------FCMKTDAQ-------- 37 
XP_021966819   60 ----------------------------------------------------------------LCSKFYAE-------- 67 
ODN06305      174 dskFESTIRIIRTCgwi---aeEKKEGASNKTDCKWIVNAGTQIDQ------C-VCTGDG-CN 225
XP_024510885  103 ---DESDTAIWKGCfskfqkdiGKIYGEYIINSCFMAESYNNETI-------C-FCNDNNfCN 154
11_pfamImport  43 ---DISELAIWKGClsnfqkeiGRIYGHYVVNSCFNAQNNSDETI-------C-FCDDKEyCN 94 
4_pfamImport   43 ---NDHNTAIWKGCfstfqlniGRMYGNYILNSCFVALNDNEESI-------C-ICSDNDyCN 94 
GAU92691      101 ---VSNVESVSRGCgk----ysGPGGSGIAENQCQETVVQGVSSTV------C-NCNTDS-CN 148
GAU92690       69 --gSSTTEQITRGCgk----ytGDGSQGLGDNQCQDHDINGVKTNI------C-NCNTDS-CN 117
EZA57302       64 ---SDGKEIKQRSC------------FPSLSPSLGAQEDLKVKSMQ------CaACNTDL-CN 104
69_pfamImport  32 ---KDGKTAIIKRC--------VNSLLSKSVNKCGDKTFEGGTGIV------C-MCSTDL-CN 75 
70_pfamImport  38 ---TSDRQIILKGC--------GGFALRKPKNECGKPTDIAGLKATm-----C-ICTSDL-CN 82 
XP_021966819   68 ---ENGIIRVERYC-----------GGSDFSNGCRDASFPDRSPGTryramsC-RCNDQDgCN 115
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