2ZWS,4WGK


Conserved Protein Domain Family
Ceramidse_alk_C
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pfam17048: Ceramidse_alk_C (This model is not part of the current CDD release)
Neutral/alkaline non-lysosomal ceramidase, C-terminal
This family represents C-terminal domain of a group of neutral/alkaline ceramidases found in both bacteria and eukaryotes. The EC classification is EC:3.5.1.23. The enzyme hydrolyzes ceramide to generate sphingosine and fatty acid. The enzyme plays a regulatory role in a variety of physiological events in eukaryotes and also functions as an exotoxin in particular bacteria. This C-terminal tail of the enzyme is highly conserved across all species and may play a role in the interaction of the enzyme with the plasma membranes. The tail is also vital for the stabilisation of the enzyme as a whole.
Links
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Statistics
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PSSM-Id: 522687
Aligned: 121 rows
Threshold Bit Score: 174.289
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2ZWS_A        479 FVDMAVALRERLPVeTSa--IAPDLSCCQM--NFQTGVVADDPYIGKSFGDVLQQPRESYRIGDKVTVAFVTGHPKN--D 552 Pseudomonas ae...
XP_032515468  562 LRDYTIAAVTGA-ViAPg-pEPQDYVNRTI--SLIPSINIDTTPVGANFGDVIQQPPEVVRpGDTVRAQFVGANPRN--D 635
19_pfamImport   1 FRGLARAIAENKVSeLLkgpEPPYFKDSQLi-SLLPLVPVDKKPANTSFGEVLEQVLPSYGLGEVVKVTFVSGNPRNsgD 79 
Q5W7F1        569 YRGLAKAIAHGTIGeLPkgpEPPFFDEDKLf-NQVRDPVADVAPVGTTFGDVLQEVNPVYKVGEIASVTFVSGNPRHsgD 647 zebrafish
18_pfamImport   1 FRGLARAIAEGKVGeLPkgpEPPFFS-NLF--SLLGEPPVDRSPENTTFGDVLQQVHPVYKVGEVASVTFVAGNPRNs-G 76 
XP_013129434  561 YRGLARAIAQDRVSeLPagpQPPFFTENLF--NFVPLALFDRKPENMSFGDVLEEVYPVYRQGDVVTVTFVAGNPRNs-G 637
XP_004086865  557 FTNLARAIAQDKVSeLPvgpEPPFFT-NLF--NLMAAAAYDAKPENTSFGDVLDQVNSIYRQGDVVSVTFVAGNPRHs-G 632
13_pfamImport   1 YTSLVESLIL-LPDsVApgpSPADILNEQI--ELLPPPQPDSVPSGKSIGDVIDDVNGIFPQGAEISVTFYGANPRH--N 75 
11_pfamImport   1 YTDLIAPLVAGNKDdVDlgpTPDLKPANQS--RIAPVPHPDKLPPGINFGDVISDVNMTYTPGDTVKVTFHGANPRH--N 76 
XP_006005660  568 FRGLAKAIAENTVSsLPkgpEPPFFNDSQLsfPRFPDNPIDRKPASTSFGDVLQEVEPSYKKGDIVEMSFVSGNPRNsvE 647 coelacanth

2ZWS_A        553 LR--TEKTFLEVVnigKD-GkQTPVTVATDNDWDTQYRWERVg------iSASKATISWSIPPGTEPGHYYIRHYGNAKn 623 Pseudomonas ae...
XP_032515468  636 LR--QESSYVAVErl---eL-GHWTTVATDADWETRFYWERVggq---ssGESRVTVMWT-SSEASNLPHRLTYYGAARg 705
19_pfamImport  80 IK--AEKSFLTVEqyeNMtQ--QWIVVHTDASWETRFHWIKGs------gALSNVTVEWHIPTSALPGSYRVRHFGHYKe 149
Q5W7F1        648 I---RDTTLVTVErfhNDtG--SWEIIHNDASWETRFHWIKGl------aGRSQAKVEWHIPQTAQAGTYQIQYFGHYKq 716 zebrafish
18_pfamImport  77 EM--RDKTFVTVEkfhNS-T-STWEVVHTDASWETRFYWIKGt------gNQSNATVEWHIPLSAESGTYRIRHFGHYKq 146
XP_013129434  638 DI--RDKTFVTVEifdNR-T-ETWEVVHNDASWETRFHWLKGs------nWQSNATVEWQIPPTALAGSYRIKHFGHYKe 707
XP_004086865  633 DI--RDKTFVTVEmydNL-T-DSWGVVHNDASWETRFHWLKGs------nRRSNATVEWHIPSSAPSGLYRIRHFGHYKq 702
13_pfamImport  76 MK--LGATYLAVQqltNDt---QWTDVFVDTDWETRFLWKEAtnelnslfKYHHVTVIWNVPLDQPSGTYRIVYYGDTLt 150
11_pfamImport  77 MKvrLGSTYLEIQrdeHGs----WTTIYTDADWSTKFTWLETnssappadITIYVIIEWNIPTDETAGSYRVLYHGDHMn 152
XP_006005660  648 HQ--AEKSFLTVEkhnTIsG--KWEIRYNDASWETRFYWTKRl-------TVSNATIQWHIPHTAETGLYRIQHFGHYKt 716 coelacanth

2ZWS_A        624 fWT-QK--ISEIGGSTRSFEV 641 Pseudomonas aeruginosa
XP_032515468  706 --EgDI--ITPFTGVSNSFMI 722
19_pfamImport 150 rKGlTTv-IKPYEGTSDMFTV 169
Q5W7F1        717 tTEnTTv-ITPYVGTSAAFKV 736 zebrafish
18_pfamImport 147 rVIfPV--ITAYEGSSHTFRV 165
XP_013129434  708 lKG-LQpvITPYEGSSDVFTV 727
XP_004086865  703 lQG-LQtiITPYEGSSDIFRV 722
13_pfamImport 151 lLGq----RKPFQGQSSEFKV 167
11_pfamImport 153 eVGt----ITPFTGMSREFQV 169
XP_006005660  717 lQG-----IKPYGGTSLTFEV 732 coelacanth
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