6BGG,6CUI,9JA5


Conserved Protein Domain Family
BET
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pfam17035: BET (This model is not part of the current CDD release)
Bromodomain extra-terminal - transcription regulation
The BET, or bromodomain extra-terminal domain, is found on bromodomain proteins that play key roles in development, cancer progression and virus-host pathogenesis. It interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5 all of which are shown to impart a pTEFb-independent transcriptional activation function on the bromodomain proteins.
Links
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Statistics
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PSSM-Id: 522681
Aligned: 146 rows
Threshold Bit Score: 34.4021
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6BGG_B          20 PMSYDEKRQLSLDINRLPGEKLGRVVHIIQSRE--PSLRdSNP-DEIEIDFETLKPTTLRELERYVKS 84   human
EIJ89205       291 EYGYEEKLKLKRRIESLAPSKLRPLIVYIQENIphVM---LDEmESLEVNLDALDQKSLRGLSNIVRE 355 
10_pfamImport    1 EFGYEEKLKLKKMIDAIPLARLAPLLTYIQENVphVM---FSElDVLEVNLDVLDQKTLRSLSNVVRE 65  
A0EI75         143 TISHNEKVEFSNNLKQLNPDQIGGIVQIIQTNSpsAFIV-VNK-ERFQIVIDNIDFDTFVKCQNQIQT 208  Paramecium tetraurelia
XP_004031797   172 PMSLQETLSFSQKIKSLPAEQIGMIVHMIQNSSsqAYKD-IDK-EKCQIHVDLIDRDTFKKINQQIDM 237 
XP_004035165   202 IITQQEKLQISQKIKQLPNQQLGIIVNIIQNNCmqAFKD-SDK-EQCQIHVNLIDYETFKKINQQIIF 267 
XP_002286530   127 DPTPEDKRTFAKLLYKITKEELGNVITDLDAKCpkALVKnSAE-DEVEINVDVISPKIFDELLSYVRG 193 
XP_001020592  1746 SMSLDEKTQLAKNIRKLPKEYWIGIWEIMTDKQfc----iADK-QKIEFDLDTTTPKQCRRLERYVKA 1808
XP_004035488   143 AMTLEEKQQLSKRITSLPQEYLIGVWEIITDRQfc----iADI-NQLELDLDEITPKQSRRLERYVKV 205 
XP_002997220    83 pMSFYDKQRLVQKITMLPSQYLRGLMDVISKYQpdTVRQ-IDD-DGYAFDLGQMNENTVWAISDYVKD 148  Phytophthora infestans T...
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