Conserved Protein Domain Family
SRP68

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pfam16969: SRP68 (This model is not part of the current CDD release)
RNA-binding signal recognition particle 68
SRP68 is a family that is part of the SRP or signal recognition particle complex. This complex, consisting of six proteins and a 7SL-RNA is necessary for guiding the emerging proteins designed for the membrane towards the translocation pore. SRP68 forms a stable heterodimer with SRP72, a protein with a TPR repeat. Specific RNA-binding of SRP68 is mediated by the N-terminal domain of approximately 200 residues of this family.
Statistics
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PSSM-Id: 522662
Aligned: 64 rows
Threshold Bit Score: 335.416
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003660447   15 LLYGDYSTYW----------------SQLSGKLLNSRK--KLNIATKHRGKFNPKApV-----TPEQIAENHEYVYLHLL 71  
XP_005850619   36 LKHSDYQRYRqaaidarppgtitpatQYCSRRLRRVYK--GVKFLHGRG-RYQKKK-L-----EPEAI-KDVRHLHIPLV 105 
XP_002946270  411 nepaeanACR----------------KHCVSRLQTLYK--VLKMQHGRT-KYQKRK-L-----DVHHI-TDVRHLHVPLF 464 
XP_018655038   29 LRHGDYQRYH----------------QYISRKLRRMRK--SLHFQQGNRSKVVPKK-L-----TPDIV-TDPRFIILAIF 83  
7_pfamImport    1 LRHGDYQRYH----------------GYCNRRLKRIRK--VLKFKMGDKRKVTPKK-------VNEPIFTDPRYILMLLM 55  
EDO32726       14 LRHGDYQRYR----------------QYCARRLRRLYK--TLHFQHGSRHAFKPKK-L-----TKELV-KDVKFLHIPLM 68  
XP_001027269   29 LKHSDFQRYR----------------KYCGHKVHKLRK--LMKFSHEK--KYQKKQ-I-----HVERL-NDPKMLQVLLF 81  
Q1ZXE8         35 LRLQDYKKYR----------------QYCSKRIQRLRS--QLRKQYGKK-NYVNKI-VlnggeTEKQI-NDVRYLQISLL 93   Dictyostelium...
XP_020438925   50 LRQDDFTAYR----------------QYCTRRLGRIRS--SMKKQLGKK-NYIAKLn------DPKNI-VDARYLLIVLI 103 
XP_006681695   24 LRQQDYQRYR----------------EYCARRIRRVRKntDM--IQGKK-RYEKKP-V-----TPTSL-VDPRSLQILLF 77   Batrachochytr...
XP_003660447   72 TAERTWAHAMTMKASHAAG--TKGMT--SKTRSHIVSRLEKGARTAERLAEALASsA-SGASPTDVLDARAYAAMLRGAA 146 
XP_005850619  106 QAERAWAYAMDLKSQLEQDm-------vPQKRQHLIRRLAKAARHAADLVALAa----QRCDARTQLEAEAYSLWMAGSV 174 
XP_002946270  465 NAERAWAYAMELKKEAEARggGAAGGidPRKRHHLIGRLAKAVLWASELARFAa----ARSDTQGALEAEAYCCWMGGNL 540 
XP_018655038   84 EIERSWAYAMQLKAESSTE---------IRKRFQMCSRLRKAVARAELLCSMEDDl--SLLDAQTKLELRAYKQWIRGIL 152 
7_pfamImport   56 TSERAWSRAMFLKQEANSE---------PRKRHHMVEKMRKAVVLADELSLLCEGs--LRVDARTKLEAQAYSAYMSGIL 124 
EDO32726       69 DTERAWSQAMELKLLANTE---------PRKRFHLIRRLQKASKHAQDLENLCDg---DMCDARTKLEAQAYSSYMKGSV 136 
XP_001027269   82 KIENNWAYAMDLKQIMQDSkdGA-----ARKQHHVNKKMAKALKWANLLNNICr----ERTDERSYQESEAYLNFIKGIY 152 
Q1ZXE8         94 KTERAWSYAMDLKAQfek-------dndSRIGFHMNRRFGKASRNSTQLYELCk----LVADQYTIIEAHAYSSWMASSL 162  Dictyostelium...
XP_020438925  104 KTERAWAYARALKQEyeq-------sdqGRLKFHMNSRFAKAAVHADQLERFCr----EVADQYTQIEAAAYAAWIRSSH 172 
XP_006681695   78 EAERSWAYAMQLKADSQYE---------PRKKHHSIKRLCRAVSSANQLHELC---QlESIDHQTSLETQAYALRLAAYV 145  Batrachochytr...
XP_003660447  147 LFERQ-KWDACLKSYAVCRIIYSALATSAkGDVFRDLLSDT-------VD---PSIRYAAYQAKIPRTLPIATIARDAFd 215 
XP_005850619  175 LLEKEsDWEGALARFLRARQLFEELAKVG-SFEQQGVCKHF-------LDqvdPTVRYCQYQISRKGGAAPSPAELLELi 246 
XP_002946270  541 LLEREsDWELALAKFTRAKKLWQELAKACpNLEGQSLYLAQarrergrVEemePNIRYCNYRISRAGGAVPADPSALLSa 620 
XP_018655038  153 FFELQ-NWAVAKEHLESAQAIYDVLLQMV-DEDSQAVYKSR-------IDdllPQIRYCAHSIGDETAATDLQRMRNQA- 222 
7_pfamImport  125 HFELK-NWISAMDLFRKSQTIYGKLGDAM-SKEEQTIYKTM-------VEemsPNIRYCAYTIGDQSAMDDLVQMHGA-- 193 
EDO32726      137 SFELQ-NWKEALELFGRSRTIYERLAGAF-SEEQRNMYLQR-------VEeitPNIRYCAYNLGESGTDINDLMQLRHCs 207 
XP_001027269  153 HHERH-QWEDALESYIKSRSIYLSLISVS-DSLQSVFFKEK-------VEfleQSIRYCHQQn----------------- 206 
Q1ZXE8        163 SLTKQ-DFKKALEEINISKTIYEKLSEQG-DHSQKELYQKR-------IEetePIIRFCLYNLKNEKNTSNKVSQNt--- 230  Dictyostelium...
XP_020438925  173 MIACS-RWLEALEAITKAKTIYSSLATSG-TPSLKQLYVGR-------VEdaePIERFCLYNMRSLDTSSNSTVLADt-- 241 
XP_006681695  146 HFERQ-EWQSALDVFASSRSIYDKLAHVAvTASHATLCQAA-------MDeidPNIRYCAYNLKFKGNQTDDIESLLELr 217  Batrachochytr...
XP_003660447  216 ----------HAA-GPELADRIR------------------DIN---PAVLEHGDADAA-Kga---ggTPAVLTWRGREV 259 
XP_005850619  247 ----------GGSgTDQLQSKIA------------------SLA---AEAQAEKAAA------------TSSLSWAGETY 283 
XP_002946270  621 vsdvgarggeLPGgGDLLQSKLA------------------ALA---QEAQMAQAAS------------TSYVSWMGVNH 667 
XP_018655038  223 ----------PDGlTLLSELQLD------------------QLL---GQARSKQASQ------------VSEVDWLGISI 259 
7_pfamImport  194 -----------GRqDPLLSQKLD------------------SLI---AESREKKVAS------------MSEIVWRNRTI 229 
EDO32726      208 ---------aGGVqDPVLAAKID------------------EVL---AQTREKEAGA------------MTEVVWCNRTI 245 
XP_001027269  207 --------------NGFILDTIDviiskmgtkmdiektptsKVA---QSEKKDQ---------------LIEVDYLGSKY 254 
Q1ZXE8        231 --------------LTIIEQSLE------------------ELK---NQENKKKSSTSStTtt----tATTTIEWKSKSI 271  Dictyostelium...
XP_020438925  242 --------------TKILKKVTD------------------DTEkktNQILSNSSSSSNtGskqqqeqPMSTVSWRQRQV 289 
XP_006681695  218 k-------tsGGPgNDLLSAKID------------------LLV---TERMHVKARA------------IHTMEWHGYSM 257  Batrachochytr...
XP_003660447  260 KIEDAAIAIAWAAVATARGRLAEKLa-----SAGA---LHPKETAAAYDEILIASQDAVDATKQAID------------- 318 
XP_005850619  284 A--------------ELQSELDG--------AMEVeggGEVDARVSLYDRMINAYGEARQAIKSVLA------------- 328 
XP_002946270  668 PVRHERVKLALHQAAEFGAQAEQ--------VMDSgegDVLDSRLALYDKAINALAQAKSHVRNAVK------------- 726 
XP_018655038  260 PVKSEKAKIAILTVEESKTELEKa--------------ETLQAKLSIYESILKLCVEAITSVRDELRtaiasepsvtgdk 325 
7_pfamImport  230 RIKNNKVRLFLIGVKEFEADLSSis------------eSDREARVEVYDRLLTECKDALQITRDDIR------------- 284 
EDO32726      246 PVRNEKVRGFILHAQQMARELDRa--------------EDLDGRMELYEDLLLECKDALQAIKDDLKgd----------- 300 
XP_001027269  255 PIKNQKAIYSYRQVEDCQKRIHE-----------LqrkTSKTNTQEEQDSILAIYNEAFNNFDECIK------------- 310 
Q1ZXE8        272 KV-DEKLDEKLKIFNEFKKENENKLpk--niNASIdttSNISPIFNIYDKLVYNLINCETIVKNDLStl----------- 337  Dictyostelium...
XP_020438925  290 RV-NEKVREKLVNYSNFVKEYDAa--------------TSDDAKFPLYEKIVKQLLDAEVMVRNELVni----------- 343 
XP_006681695  258 DIHNEDLMAMIMEMQEISAKINGEVqgngivVDGRvdeSQFAGIMAEYDKLLGLGWDAAKLSERDIKed----------- 326  Batrachochytr...
XP_003660447  319 ------ELRAEGVTQSDARMQSL--QITRTAVNYEMISWRIGRNRVLVGENDGVKMDFSGpVSQKKKKRKqqqqqeeeqe 390 
XP_005850619  329 --------LGQGGADSAQLRGEL--MALDRAVQGLVLERTIQRNLFLAGDAEARFARTQRrQLSGQRQR----------- 387 
XP_002946270  727 ---------GLAGPDAEAHFKEL--EALEVAVEGLRLQRTVERSEVHLAHTRTRFVAGLQrLAAGKKIK----------- 784 
XP_018655038  326 ntaavvASSKFGQTLGSEKVSRL--QLLYTYLQYLKLSKTIDRTLLHIETTISSLAEGSHkRNQLA-------------- 389 
7_pfamImport  285 ------TDPHSKATEKTNQVSDL--QFLQSYLSYLRLTKTIERNLILVGGLQANNFPVEKaEGDS--------------- 341 
EDO32726      301 -----lVSEELKVHKTEAQVANL--QFLHTYVTYLKLTKTIERYLLLAESMKNQLPANLQdTANGSEPL----------- 362 
XP_001027269  311 ------VIQKEKSDEKNSEAENLiyTNILSFLNLNKQKFILDRNIILIKNAVQQFDKEDGvNNLEALTTKk--------- 375 
Q1ZXE8        338 ----vrVNLKNKSVKSEIEEQST--RILLAYIMYHKMKYLYERNSILITMMQRVLDGEKVdESAIKK------------- 398  Dictyostelium...
XP_020438925  344 ----vrVNIKNKTVKSEVEESDL--RALLAYISYHKYRYLYNRNETLINQYTQSADNSSSnKQQTTVVNS---------- 407 
XP_006681695  327 ----lvAVMKVKSSKSDMHSAML--KLIKEYVTYTRLEHTFDRDILLEQATSMRLKNLVHsSGSVE-------------- 386  Batrachochytr...
XP_003660447  391 gdrskdeAPGRQIARLKEKVVLYDGILQDLESIKELPG---VANDQDLSERLDATSQYFTALKSLAIARSHAVAGNAVNS 467 
XP_005850619  388 -------GERERPARAEDVVRLYELLVANTSELNELAAhvgGAAGEMLMDDCAAKQAHYQAARCLYLAHSMLAAEKYREA 460 
XP_002946270  785 --------DKERHARPEEVVRVCDLLSRYLEDLADLGArmgGRAGEALHDVAA---------------------ARALEA 835 
XP_018655038  390 ---------TSAYPKPQELSRLYDTLVQNFQEIISLPCl--VQDHIGLKDLLYAKMLSYRSYRCYYLALAYNCSKKYTEC 458 
7_pfamImport  342 ---------AHRGPKPSDFIRLYDGVLHNLTEVLSLPG---IEVDSEISDAVGSQRAAFQAFRCFYVAQAYVNEKKWAEA 409 
EDO32726      363 --------PNKKLTKPEDMVRIYDIILQNLSDMSELHS---VEDDLELTKEIAAQTLEYKAYRCFYIAHSYLLAKKWREA 431 
XP_001027269  376 -------AFKLKLIRPTEIIKLCDNLLQVFKQIIEVER---QNTNLENYRKLDVLEFHFKAIRCYYVSCVYLANSKYIET 445 
Q1ZXE8        399 ---------KVKKVTWNDLVRLSTHQVKVYTIMSESRD---TDSNKEIARDQDAQLILLKSIRLYYIAVCLAKSLKFSET 466  Dictyostelium...
XP_020438925  408 -------GGKKKKISTRDIIRILTNQIKVYSRMIE------NRNEQRQDAVLEAQLQLLKATRLYHIANGLALAKKWSET 474 
XP_006681695  387 ---------KRPSQRREELIQLDITMLQVVNEMKELDI---IETDLALGHLVSSKGFFVVAQRLAHTADIYTADQKYAEA 454  Batrachochytr...
XP_003660447  468 LALVKHALDQTNTAAPSLSSPEN-NdDdddaaftPRNIQVTKRDLTLLHDTLTGELQRCLALAEI---FN--NNNknsss 541 
XP_005850619  461 AGLFGRAADRCKQAASKYEDCS-------------KPDVAAGEQLEALAQQAAAWGAAAAAELRAge----lREKeaaqd 523 
XP_002946270  836 WALLSRSQDRASAAADQLRGLPAgDpAae---vlLRGRDGLLEDLGELVKQATAYKAVAQAEMFAa-eLK--AKDellqa 909 
XP_018655038  459 SALLTRAIQHAEKAVTSLEHSIStWtKaeeciapGPSPDALSKSLQSLILQAESEDFTCKAASMLdk----vEENepvst 534 
7_pfamImport  410 MALYDRVLEHSRKAINMMMRSSEdIa---------EFKLVETGRLESLVETIAFNRYRVHASAILdsvAGkeGEKkdvd- 479 
EDO32726      432 AVLYDRVTSHANSAVSHFREC--------------QNFQSQASRLQDLASLSRGSKCSAHASSILd--------Seeitd 489 
XP_001027269  446 LSLLKVAENIVTNSSKKFVDMRD------------NFVEDYVEESDILMKKIKYLEIKAKLGLVEnt----tEEEtvite 509 
Q1ZXE8        467 MAVLDRVLTNIQNVRKTNTKNQQ-----------------ILNDTNELESNIKKQRSQIHANSFIqq----lSENqdlkn 525  Dictyostelium...
XP_020438925  475 MATAERVSSMIATARK-------------------NKNADVVKRADELDKLVASIRSQVHANAFIeq----mSNNedlkr 531 
XP_006681695  455 LVLLNKAMEQVHLSRTSVVEFKRkIiKh-----dQQMAVNMTKLLDVLSQSICNRSLITKAKVYFendDK--VPYvslsk 527  Batrachochytr...
XP_003660447  542 ttiptdkaAEPFQqattttaaaaeaaaaTTKPPPLSSRLS-DYPA-GG-VDLDN--------------IVTYPPRLEPFP 604 
XP_005850619  524 glegmslgGEAAAgr-----------krGREDAYLAEDLD-AWESfVGpGKGQAr-------------ICRMPPALRTVP 578 
XP_002946270  910 gvgglslgDQQQQqtag--------pqqQQQQTYLLEALD-KWESfAGgPTAAAgtgagasgakapprLHKAPYGFMAIP 980 
XP_018655038  535 tplagttgVDA-------------------SRKVLIDRLD-IYADeKSvEKSFNnfv---------ypFVHLPPKFHPVP 585 
7_pfamImport  480 ------------------------------tsipILERLD-VYHEdVAtSSLNIgkpns----kvpqmTSAYPPKFEPVP 524 
EDO32726      490 klasatieD-----------------------KTLAERLD-VYHVdQSlVSKKPh-------------VTTFPPDFQPVP 532 
XP_001027269  510 kladsnldGKVTNktiqsl---mkeqeqGNKLNVGINRLN-SIP------------------------IFALPPKPLLAG 561 
Q1ZXE8        526 qmsslsigGITTA---------------SGKSNDLISGLD-SFDTsFLtEKK----------------LVQLPPQLQPVQ 573  Dictyostelium...
XP_020438925  532 qmselslsSGGDNns------------aAVASKDLLSGLD-NFDTsFLaEKR----------------LVEFPPPLQPAP 582 
XP_006681695  528 tvqdmsigTHKIN----------------QMGVGRAEHMKvFFQPsEGvIPV----------------VQSIPPAFEPVS 575  Batrachochytr...
XP_003660447  605 VKPLFLDVAWNYI 617 
XP_005850619  579 fRPIFLDTALNYI 591 
XP_002946270  981 VRPIMLDTASNCv 993 
XP_018655038  586 VKPIFFDLALNHI 598 
7_pfamImport  525 CKPLFFDVALNH- 536 
EDO32726      533 CKPLFFDLALNHV 545 
XP_001027269  562 CKPIQFDLvdeyi 574 
Q1ZXE8        574 AKPIFFDLAFNSV 586  Dictyostelium discoideum
XP_020438925  583 TKPLFFDLAFNQc 595 
XP_006681695  576 FKPMFYDLAYlgm 588  Batrachochytrium dendrobatidis JAM81
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