Conserved Protein Domain Family
HRG
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pfam16954: HRG (This model is not part of the current CDD release)
Haem-transporter, endosomal/lysosomal, haem-responsive gene
HRG1 is a family of conserved, membrane-bound permeases that reside in distinct intracellular compartments and bind and transport haem in metazoa. These proteins carry four transmembrane domains, 4xTMs, modelled here in two pairs, the two N-terminal and the two more C-terminal.
Links
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Statistics
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PSSM-Id: 522655
Aligned: 38 rows
Threshold Bit Score: 26.5534
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EFO93948       33 INVRIAYTICGIIIGLFWACVYIFAWKVNIQ---------SVSlvimlflfqnwvalatcLvATSFAFETFFFYFSIKkd 103
13_pfamImport   1 --ISLSYSCVGVLVGFSAFLVWNFA--YKQPwtaamgglaGVL--------------------------ALWTLVTHTmy 50 
Q5ZHU0          7 LALRLAYAAAGALMGFSAFFTWSLAPAFRQPataaagglsGVL--------------------------ALWALITHVmy 60  chicken
1_pfamImport    1 -VIRTPYQNVSSVAYYSIFLVWTVV--YRQPataamgglaGVL--------------------------ALWVLVTHImy 51 
Q21642        106 LRCLAAVGATVSFLSFIAMVFCLVVAGIEHQ---------TLDkq--------------gLmGANLWIAAVWFFMTSK-- 160 Caenorhabditis...
6_pfamImport    1 LKCIATVGATVSVITLIAMVYCLVVAGIEHQ---------TIDre--------------gLkGANLWIAAVWFFMTSK-- 55 
XP_002633261   79 fQLMIWPNIFIGLLGLIGCLVCYIIAGITHQga------gSIQa----------------MyGENLWFTGSWSLVITK-- 134
XP_003963508    6 IYISIGYATFGTLVGLSAFLVWNIA--YKQPwtaamgglsGVL--------------------------ALWALVTHImy 57 
Q4FZW7          7 LWIRIIYAAVGTLFGLSAFLVWNVA--FVQPwtaamgglsGVL--------------------------ALWALITHImy 58  African clawed...
Q6P1K1          8 lGLRAAYSGISSVAGFSIFLVWTVV--YRQPgtaamgglaGVL--------------------------ALWVLVTHVmy 59  human

EFO93948      104 tilkW 108
13_pfamImport  51 lqdyW 55 
Q5ZHU0         61 vqdyW 65  chicken
1_pfamImport   52 kqdyW 56 
Q21642        161 ----W 161 Caenorhabditis elegans
6_pfamImport   56 ----W 56 
XP_002633261  135 ----W 135
XP_003963508   58 vqdyW 62 
Q4FZW7         59 vqdfW 63  African clawed frog
Q6P1K1         60 mqdyW 64  human
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