Conserved Protein Domain Family
KCH

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pfam16944: KCH 
Fungal potassium channel
KHC is a family of fungal proteins carrying three transmembrane domains. It is a member of the fungal potassium channel family of transporters, and includes a pair of homologous sequences that localise to distinct zones of the yeast plasma membrane and are induced during the response to mating pheromones. Together KCH1 and KCH2 promote low-affinity K+ uptake and are essential for K+-dependent activation of HACS - a high-affinity Ca2+ influx system that activates calcineurin and is essential for cell survival - in S. cerevisiae cells responding to mating pheromones.
Statistics
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PSSM-Id: 496227
Aligned: 83 rows
Threshold Bit Score: 250.897
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q0CJR3        17 KWDYINLNDFKSESCWTPFSYFF-IYVFLLISLAVYAVDTFTAVNLLAFSRWAGQ-IKPTIPFTISRWIFAVCIIISFVL 94  Aspergillus ter...
Q6FVS3        14 TFDDLEEEEFKNYKFKTVLSYIFeIGVMNGLKVAFFVSDIYTCVKLLAYNSWSNNvIKPYISFKVTKWLFTACIFASIVI 93  [Candida] glabrata
XP_001644176  14 TFDDLDASEFKNKKRGTVCSYIFfVLILNFLKTALFISDVYTCIKLLAFNSWSNNiVQPYLPFRISKWLFSACILFSIVL 93 
XP_003686259  14 TFADLNERKFKNYRFGTLASYLFfVIIMNILKVALFISDIYTCVKLLAFNSWGNNlIKPYLSFKISKWLFSGCIFFSIVL 93 
XP_003668394  14 VFDDIDPLLFLNHRFKTIIKYILsMWLMNLLQLALFISDIYTCIKLLAFNSWSNNlIKPYVSFKVSKWIFSGCILGSIAL 93 
XP_003674245  14 LFDDVDSHLFENVHFKTVMSYIFgVWLFTILKVTFFVSDIYTCVKLLAYNSWSGDvIKPYPSFHISKWIFAGCILGSICL 93 
XP_022462725  16 RFPDVDIDLFKNYRLKTVLSYAVgTWAFGLLKLALFISDLYTCIKLLAYNSWSNNiVKPYLPFRISKWLFSGCILASILL 95 
XP_003957229  14 TFDDVDLYLFFNFRFTTILSYAFgTWFFIFLKCASFVSDIYTCIKLLAFNTWSNSiIKPYLSFNISRWLFSGCILASIVL 93 
XP_003682087  15 TFDNVDPSLFRNFRFCTLFNYIVwSWGLTLLKVALFVSDVYTCIKLLAYNPWSNNiIQPYLPFRISKWLFSGCILASIVL 94 
XP_002552356  14 TFDALDCSLFRNFKFMTVVNYAFfVLFLTAMKIALFISDVYTCIKLLAFNSWSNNvVPPYIPFRISKWLFSGCILASIVL 93 
Q0CJR3        95 LVLRWLHAIRAIRSGSIAQCYLDSLAVRVQSIRpgkrgrGWRRFIVFAELtKSKKGAEYVALFAYFSFESWMNTVFADGP 174 Aspergillus ter...
Q6FVS3        94 LLIEAAIGFRIYRTRNISLTYVNNFSRNTYSIK------SYSKFCVYNKI-TPKGFFQKVSFFTFFELRNCIRLLFTDTP 166 [Candida] glabrata
XP_001644176  94 LIWELIRGLRVFRTKNIALSYVNNFCQTYYSLK------SYSTFCVFNKI-TADNRFQKIAFFTFFELKNCFRILFADTP 166
XP_003686259  94 LIWEFIRSIRVYKTKNIALSYINGFCKHYYSLK------NYAIFCFFEEL-SVDSKFQQVAFFTFFEMKSCFRFLFADTP 166
XP_003668394  94 LLWEIICGIGIYRTRNISLTFVNNFSRNVYSMT------EYPKFCIYDKI-SSKGAFQKIAFFTFFELKDCMRLLLTDTP 166
XP_003674245  94 LIWEVVFGIKIYRTRNISLTYVNNFSRNAYSLS------DYPKFCIFHKI-SSKGFFQKVAFFTFFEIKDCIRLLLTDTP 166
XP_022462725  96 LLWNVIHAIRIYRTKNIALCYVNNICRNSISFV------NYPKFCIFDRI-SSKGTFQWFAFFVFFELKDCLGLLFTDTP 168
XP_003957229  94 LIWEIISGIRVYRTRNIALCYINNFSRNLYSMT------SYQKFCVLNKI-SAKSFFQKTSFFVYFEIRDCIRLIFADTP 166
XP_003682087  95 LIWETISGIRIYRTRNIALTYINDFSRTAYSLS------NYNFFCVLNKI-SPTGAYQKVAFYTFFEIKSCIRLLFTDTP 167
XP_002552356  94 IAWEIINGIRIYRTRNISLTYVNNFSRGAYSLS------QYNKFCVYNRI-SPSGAYQKIAFFTFFELKDCLRLLVADTP 166
Q0CJR3       175 RQVVNAITLYSVMRMDLLPG-GehAhkanddTPGVVQFFDNVKILAEENNLRALVLFGMLFTLVIWVLSVLKLLLAIILY 253 Aspergillus ter...
Q6FVS3       167 RQVFNALTLWSVLVTV-NN-----Gadl-grLETFHGLINKIKTIADTNHAEAVILSFMLFSFVLWAFFMFKFCLALLSS 239 [Candida] glabrata
XP_001644176 167 RQVINGLTLWSVLITT-SD-----Gatl-gdLETINGLLQKIKNIAQTNHAEAVILSLMLFSFVIWCIFITKLTVAMICS 239
XP_003686259 167 RQVINGLTLWSVLISE-SN-----Gknl-sdLESASNLLQKIKYIAQTNHEEAILLSFMLFSFAIWCIFFIKFTIAVICL 239
XP_003668394 167 RQVINGLTLWSALVTV-HA-----Nadl-gdLESFSGLINKLQRIAETNHQEAVILSFMLFSFIVWAFFMARLIVAMFCA 239
XP_003674245 167 RQVINGLTLWSVLVTV-RD-----Nsyl-gdLESLSGLLNKIKEIAKSNHQEAVILSFMLFSFIVWLIFMAKLALALICS 239
XP_022462725 169 RQVINGLTLWSVLVTVHSDLdN--Nmdl-gdLESFQGLINKIKGIAQSNHQEAVLLSFMLFSFIVWMFFMAKLIFAMICS 245
XP_003957229 167 RQVINGLTLWSVLITT-QE-----Dydl-gdLESIQGFANKIKMIAETNKEEAILLIFMFLSFILWAFFITKFICAVICS 239
XP_003682087 168 RQVINGLTLWSVLVTV-KP-----Nssl-gdLESFDGLIAKIRTIAQTNHEEAVLLSFMLFSFIIWAFFISRLVLALLCS 240
XP_002552356 167 RQVINGLTLWSVVVTV-DQ-----Ssdl-grVESFSGLVAKIKTIAQTNHEEAVLLSFMLFSFVIWAFFITKFVAACLCS 239
Q0CJR3       254 LIFLFHHIPSED-GSLKAYCRRKINNR 279 Aspergillus terreus NIH2624
Q6FVS3       240 IFVYYNLIRRHRyGSLKAFVCITIDKK 266 [Candida] glabrata
XP_001644176 240 IFVYHELIMMNKfNGLREYVCVTVNIK 266
XP_003686259 240 LYVYHKLITKQKyKGLREYVCISINNK 266
XP_003668394 240 FFVYFRLIKEQEyNGLKEYVCITVSRH 266
XP_003674245 240 IYVYFRLIKDRRyASLREYVCVTVSNH 266
XP_022462725 246 VFVYFRLIHEKEyAGLRDYVCIAICRH 272
XP_003957229 240 PFVYFALIKEAKySSLREYVCMSISDH 266
XP_003682087 241 VYVYYKLINKHRhSGLREFVCVTISRN 267
XP_002552356 240 IYVYYRIFNERNaSGLKEYVCVTVSEH 266
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