Conserved Protein Domain Family
Glyco_hydro_63N

?
pfam16923: Glyco_hydro_63N (This model is not part of the current CDD release)
Glycosyl hydrolase family 63 N-terminal domain
This is a family of eukaryotic enzymes belonging to glycosyl hydrolase family 63. They catalyze the specific cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase EC:3.2.1.106 is the first enzyme in the N-linked oligosaccharide processing pathway. This family represents the N-terminal beta sandwich domain.
Statistics
?
PSSM-Id: 522647
Aligned: 67 rows
Threshold Bit Score: 185.149
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_003285640   70 TLYWGTYKPQQYFGLKTRS-IEPINTGLIWSTPNINYGFN-RFNYKTSQGg-DGVASYKWLKHDGKNFGVQEIQDSKGNL 146 
XP_016290442   72 SLLWGTYRPQIYFGLRPRL-PDSLLTGLAWFGLQDYANYQh-IRHQCSDQ--DGMKGFTWKYHDGREFGVQEINDNENNY 147 
GAC71712       72 SLLWGTYRPQIYFGLRPRL-PDSLLTGLAWFGLQDYSGFQk-MRHQCSDQ--DGMKGFTWKYHDGREFGIQEINDNVNNY 147 
XP_001731803   24 SL-WGTYRPQLLFGMRPHV-LETLVTGLVYFSPESLQRGI-PVRHSASEN--QGMDAIKWVYHDGRNFGIQHLVDRENNY 98  
XP_018739409   28 TI-WGTYRPQLFFGLRPRV-PRTLVTGLAWFSTADYEHAS-VLRHSASDN--DGIESFKWLYHDGRNFGVQEIIDRKYNY 102 
XP_004361653  729 KLYWGTYKPHLYHALKSRS-KQPITAGLIWSVPNIDKLYT-RYLHRVGGQaiDGVERYEWIRHDGYNYGEQEIEDKAGNL 806 
XP_002679093   75 TMKWGTYRPQVIFGMKTRN-PKSVITGLMWNRADTWDGVN-KMRHNSNMD--FNNVVYGWNRHDGQNFAMQTIKDHENSL 150 
CBN74169       78 SMLWGTYRPGVYFGFKTRTsPVSVTGGLMWHGGDGHNGLP-PLRHECSEG--DGLGPYGWVEHDGRSYGKQDIVDKKAGV 154 
XP_005849528   26 QLLWGTYRPGYYFGMRMRR-PQSLLMGLMWVDPQRQDPLG-NIRHEAQQR--DGLAKYGWLQHDGQGYGLQQLWDEQ--F 99  
XP_014566456   38 SLFWGTWRPNLYLGMRARV-PDSLMFGLIWYGVHDYASHAkA-RHSCEQD--DGLAAYDWLRHDGRTSGAQIISDPLNNI 113 
XP_003285640  147 NLTTSFVK----KSGKk---------GGD-------WSIRVSGKTNE----TNInsQPITSLIYFIHDEsikrs------ 196 
XP_016290442  148 RLETSFLKv---NTANk--------nGGS-------WGARISGTVLD----PTK--PASLTTFWYTAIEtl--------- 194 
GAC71712      148 RLETSFLKv---DTRNs--------nGGS-------WAARVSGTVMD----PAK--PAALSTFWYTAIEsl--------- 194 
XP_001731803   99 MIETSFVKtg-hTEGQ----------PGH-------WAARVRGTVLD----PSK--PAHLLTYYYVGSEsa--------- 145 
XP_018739409  103 RLETSFVKag-hEHGQ----------PGH-------WAVRVRGTVLD----DSK--PAQLSTFFYVGSE----------- 147 
XP_004361653  807 KLIISFIK----KDKT------------N-------WSVRVSGSQLN----TTKp-VPMTSLFYYIQDEs---------- 848 
XP_002679093  151 QIETRMMK----HVSEntfvpsvnekGGD-------WTVRLIGKELK----QMKt-KQAMSVCFYIALEnd--------- 205 
CBN74169      155 RLVTSMVKpaqlKDHS----------SSDrdtsdvlLASRVEVFPAGs---DAS--LRPSTIYFYIGLDcnaavnndsee 219 
XP_005849528  100 NITTAWAKhlcpDCGL----------GGD-------WGASVSIEERHigasDQP--RRRLLEDEYAEPDgdeggeqle-e 159 
XP_014566456  114 NLRTSFLKv---PGGQh---------GGS-------WALKINGRAID----PMQ--PARIALTPYFGIEg---------- 158 
XP_003285640  197 ---rgetNFLSVQnHKkgdtdniNGD--------------------LQIKGEH---KEIGKYTLYFSD------------ 238 
XP_016290442  195 ------gGTLGLEtEV-------EPGqgie------------rhrpVRLAGSV---PGLGDFVLRVEEpeaahgnsntng 246 
GAC71712      195 ------gSSLGLEtEI-------EPGsgie------------rqepVRIAGTV---PDLGDFVLRIEEpdaahgnanndg 246 
XP_001731803  146 ------rHSLQVD-----------EH--------------------GMVHG-----PNLGGFSMRTES------------ 171 
XP_018739409  148 ------------------------DSea-----------------sFTIQGEQlhgTELGGFSLRTQE------------ 174 
XP_004361653  849 ----------------------mTDQkdgkgltysqtdgvskgekdVYIDGSH---PELGRYTMTLSN------------ 891 
XP_002679093  206 -----geGSFRISgIQgskkqglPSNl------------------pVIIRGNS---GDIGDFSMYFTS------------ 247 
CBN74169      220 scfaggtSGLEVVhPEsss------------------------qqsLLVRGAH---PQHGAFDLEAAV------------ 260 
XP_005849528  160 qqqrpqvASLR-----------------------------------PVISGRT---APVGNWQLHLQRg----------- 190 
XP_014566456  159 ------sGSFELEsKE--------AEdgi--------------lspVVLNGQT---GDLGSFSIRIEDgk---------- 197 
XP_003285640  239 -------ISnKEKQQETLKKyKLvdeHPdIEGWRYYGVSKFT-ENNWDi---LPTIFDMTTKIHLNPVAD--KWVKDq-r 304 
XP_016290442  247 nqfvtrhSG-SATADDYAET---------VGKSHVFGKRIPV-DTVWK----GKDVIQNDIAVRLQQAIQ--TFGKD--- 306 
GAC71712      247 nqfigrpSA-NTQAGDFADT---------AGKTHVFGKRIPT-ESVWK----AKDVILNDLMVNLQQSAE--TFGHE--- 306 
XP_001731803  172 ------------ASYNHPID-GD------SEM-MFAGLSIDP-AETWR----GADVILGEHVHQHQEMMR--Q------- 217 
XP_018739409  175 ----------------HPGQ---------TPMKAFTTMRVPS-HNVWR----GPDHILADMRPHLQAMARs--------- 215 
XP_004361653  892 -----------LDATNTPKSsMFldtQPsVQDWRYYGQSETS-DNRWDi---PTVMFDESTKEHIQSYYS--KWLSSekk 954 
XP_002679093  248 ---------------NEKSQvDE------HANFYFYGVKRTP-SDVWKigdeVKEMFSSQMKKSFQQMIE----DQQerr 301 
CBN74169      261 -------------VSNRDSDsSSsemEGvVAFLGKKGVPMAD----------AKKEVEKRLEAHRRASRRapTSEKAdrg 317 
XP_005849528  191 ----------TSPSGATPGA---------ILAVNYLAVATPHmHNLTN-----------LVREGVMASVRqqHAAGQqqy 240 
XP_014566456  198 ------sTV-SVPVSSYQDEfGD---R--LSRYAYISRAVGK-GQIWR----AKDVIMSDAAQYGNALVE--KYGQD--- 255 
XP_003285640  305 KiiIPTLPNII 315 
XP_016290442  307 N--MPDPALTL 315 
GAC71712      307 N--MPDPAVTL 315 
XP_001731803  218 KaaQPSAYLRL 228 
XP_018739409  216 QevWPPAAEAM 226 
XP_004361653  955 QqtVFVPTLPN 965 
XP_002679093  302 QkgLPEQKDYP 312 
CBN74169      318 PfvLPNEADAG 328 
XP_005849528  241 RlvLPDTTQPG 251 
XP_014566456  256 N--PPEPAQVL 264 
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap