Conserved Protein Domain Family
LIAS_N

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pfam16881: LIAS_N (This model is not part of the current CDD release)
N-terminal domain of lipoyl synthase of Radical_SAM family
LIAS_N is found as the N-terminal domain of the Radical_SAM family in the members that are lipoyl synthase enzymes, particularly the mitochondrial ones in metazoa but also those in bacteria.
Statistics
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PSSM-Id: 522622
Aligned: 8 rows
Threshold Bit Score: 132.986
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
B6K4J2         13 IFGAGISAFRVQGRKCASDLSKALASGPKFSDFLKGDKEEQLKPEeayELEENVVLPNGSv-HKRLPSWLKTKVPLGTNF 91   Schizosacchar...
XP_002709320   16 VFGRYLCSPVRTLSSLPDKKKEFLQNGPDLQDFLSGDLADKSTWD---EYKGNLKRQKGE--RLRLPPWLKTEIPIGKNY 90  
3_pfamImport    1 VLGSHLCNQYGTSGSLPGEKKEFLQNGPDLEDFVSGDLSDKSTWA---EYKGNLKREKGE--RLHLPPWLKTKIPMGKNY 75  
EDX11239       17 VVATRAAS---TNAEKLEEIRERLAKGPNFQDFVQNPDNTRSEWE---QYDGKLRREKGEeqRLRLPPWLKTTIPVGKNY 90  
XP_004994404   55 RFSSSSSSSSPPSSS-TNTKRVIPEDGPGLDDFISNLPPPPAAQA-------SKPLKKKQ--RLRLPEWAKTKIPLGANY 124 
A8N1T1         17 CLATASTTPAAASTSRTSTFRKTLEEGPTLDDFIAGDVPNN-----------RVVLGNTS--APRLPSYLKTSIPTGASF 83   Coprinopsis c...
XP_064419371   32 IFV-TLCSQIRPSSTLPDEKKELVQHGPDLQDFMSGGLSDKSTWA---EYKGNLKRQKGE--RLRLPPWLKTEIPIGKNY 105  coelacanth
XP_028902608   12 VFGSHLCYRFRRLSSLPDEKKEYLKNGPDLQDFVSGDLSDKSAWA---DYKENLKRQKGE--RLRLPPWLKTEIPIGKNY 86   platypus
B6K4J2         92 NKIKNDLRGLNLHTVCEEARC 112  Schizosaccharomyces japonicus yFS275
XP_002709320   91 NKLKNTLRNLNLHTVCEEARC 111 
3_pfamImport   76 NKLKNTLRSLNLHTVCEEARC 96  
EDX11239       91 AKIKAQMRELKLSTVCEEARC 111 
XP_004994404  125 HRIKSNLRDLNLHTVCEEARC 145 
A8N1T1         84 SKIKKDLRGLNLHTVCEEARC 104  Coprinopsis cinerea okayama7#130
XP_064419371  106 SKLKDTLCNLNLHTVCEEARC 126  coelacanth
XP_028902608   87 NKLKSSLRNLNLHTVCEEARC 107  platypus
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