4EGC


Conserved Protein Domain Family
SIX1_SD
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pfam16878: SIX1_SD (This model is not part of the current CDD release)
Transcriptional regulator, SIX1, N-terminal SD domain
SIX1_SD is a family of eukaryotic proteins, and it is found N-terminal to the Homeobox domain. As a transcription factor it lacks intrinsic activation domains and thus needs to bind to the EYA family of co-factors in order to mediate transcriptional activation. It is the SD domain that is necessary for this protein-protein interaction, binding to the C-terminal region of EYA - Eyes absent homologue proteins.
Links
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Statistics
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PSSM-Id: 522619
Aligned: 48 rows
Threshold Bit Score: 120.747
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4EGC_A       379 FTQEQVACVCEVLQQGGNLERLGRFLW-SLPA-C---D-----HlhkNESVLK----------------AKAVVAFHRGN 432 synthetic const...
EGT34079     116 YSIEQMEAIATSLFQARDGERLVSFFN-QLKAiYgatAln-qiV---SEPILV----------------AYTYALYHSND 174
XP_045092727  93 YNLDQMEAICTSLFQARDGERLVAFFN-QMKEmYgsnAld-hfG---SESIVV----------------AYTYALYHSND 151
EFP10975     120 NYQFQMEAICTSLFQARDGERLVAFFN-QLKTvYgsnAld-hfG---SEAIVVgeespvkmelrvddlyAYTYALYHSND 194
O17894        97 YSMEQMEAISTSLFQARDGDRLVAFFK-QLESlYgpnAvd-hlR---SEAIIV----------------AYTYALYHSNE 155 Caenorhabditis ...
2_pfamImport   1 YTLEQMEAICKSLFQARDGDRLVAFFK-QLEDrYgsfQldnwrF---SETVVV----------------AYTYALYHSND 60 
3_pfamImport   1 YSLAQIETICIALFQAKDGRKLVSFFE-DLKMaNqcvAle-nwG---HETIIV----------------AYTYALYHSND 59 
EFP10969       1 M--NQMEVICTSLFQTRDGERLVRFFD-QVESvYgvnSle-rfG---SEPMVV----------------AYAYALFHSNN 57 
XP_003373040  18 YTDEQLMCICETLCQAKDYPSICRLFDyLYPNeYlh------sT---HPSLMR----------------ARLLYLLMKCR 72 
XP_009012183   4 FTKEQLMCICEVLLKECKYDKLRELLV-SNEFrTy-----------eNDIFVL----------------VRIKVHLHYSE 55 

4EGC_A       433 FRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLR--GRPLGAVGKYRVRRKFPLPR 489 synthetic construct
EGT34079     175 FEQLFNLLATHSFQHIYFNDLQDIWHHARYRESQLKR--GKELNPVEKYRLRRKFPPPK 231
XP_045092727 152 FERLFHLLSTRHFHATFFADLQEIWHYARYKESQLKR--GKELNPVEKYRLRRKFPPPK 208
EFP10975     195 FERLFHLLSTRHFQQIYFTDLQEIWHYARYKESQLKR--GKELNPVEKYRLRRKFPPPK 251
O17894       156 FETLFHLLSNRHFQQRHYNDLQDIWHHARYKESQLKR--GKELNPVEKYRLRRKFPAPK 212 Caenorhabditis elegans
2_pfamImport  61 FETLFQLLSSRPFHHSHFSDLQEIWHHARYKESQLKR--GKELNPVEKYRLRRKFPPPK 117
3_pfamImport  60 FDTLFQLLSTRPFHQSHFKELQDIWTDAKCKESELKR--GKRLTAVERYRLRQKSTFPS 116
EFP10969      58 FTKLYNLLSTRNFDKKYFDDLTKIWYEAKYKEAQLNRksGEELTAVERHRLRKRTELPS 116
XP_003373040  73 FKEIYDLLSSSVFDSRYHEELQEIWWQAHYAELEQAR--CKPLGAVEKYRLRKKHPPPS 129
XP_009012183  56 YDSVYHLIMNRLFNKCYHKELQMLWDEAHYRQYQTKK--GL-LMTTDKFRIRKKHPYPA 111
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