pfam16859: TetR_C_11 (This model is not part of the current CDD release)
Tetracyclin repressor-like, C-terminal domain
This family of bacterial transcriptional repressors is characterised by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity.
Jiyao W et al.(2023). "The conserved domain database in 2023.",