6P7W,6GYS


Conserved Protein Domain Family
Cep3

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pfam16846: Cep3 
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Centromere DNA-binding protein complex CBF3 subunit B
Cep3 is one of the major components of the CBF3. It dimerizes and in so doing forms a large central channel that is large enough to accommodate duplex B-form DNA. The dimerization region is followed by a linker to the zinc-finger domain at the C-terminus. The CBF3 complex is an essential core component of the budding yeast kinetochore and is required for the centromeric localization of all other kinetochore proteins. Cep3 is the only component with DNA-binding properties.
Statistics
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PSSM-Id: 407093
Aligned: 14 rows
Threshold Bit Score: 566.563
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6P7W_A       113 YECLFSKESIFKILDHSLERLGWLYFGFFTDISELPYQMERYWNEYESMNinleNEEattrqttfkksADQILWDLVLRS 192 Kluyveromyces l...
CAR25751      98 IMDLVDLDQSFQLLDYSMERLGPLFFGCLSDIGEIYVKLDDYWGRRDEGV----PSN-----------LDECYWDALLWA 162
CCE93637     101 WCNFLSREQSFALLDYSIERLGVLYFGCVSDISELYLILEMYWYRREHKN----EKDvv-------ltVDAHYSDALVWS 169
XP_001645691 109 LMACLNEEDSYSLLNYAVENLGPLFFGCLADVSELYPMLDRYWQRRNLHR----QKNgsv-----ifsVDENYETTLLWS 179
CAR24189     107 WRDGLNMDTSFKLLDFAIENLGSLFFGCVSDVGELYFKLEEYWGRLNDTQ----AAPt----------TDSLFSSAILWS 172
XP_003645686 102 WMVYLNAEASFKLLDYSMEKLGGLCFGCISDIGELYLKLEEYWARQEDKD----YTLs----------VDDYLWGSLIWS 167
Q755L4       100 WSNYLQAETSFKLLDYSMEKLGGLYFGCLSDIGELYLKLEEYWARRENKD----EPSs----------IDEYLWDTLIWA 165 Eremothecium go...
XP_003955914 107 WQDCLNTEQSYSLLNFSVENLGPLFFGCIVDINELFTQLERYWRRRDKES----RTRntfndtvakfdSDDYLWDALLWS 182
CCK71869     106 CLEYLQEGPSFNILNFSLENLGALYFGCIGDINELFLQLEMYWRRRKHGP----YASt----------SEDYYWDALLWA 171
Q6FTY9       104 WESSITETGSYKLLNYTIENLGTLYFGCIGDVTELYKILEQYWDIKEDQS----SKLpf-------sdSDKCYSRALLWS 172 [Candida] glabrata
6P7W_A       193 VIVMTIYYMPAKSILSLVDIDAIEKYPLDfSESNEgvde--lkkKYEIFDYCLRHTLNKVLRTIFTLPPDVRTLQIFLIL 270 Kluyveromyces l...
CAR25751     163 IFTMAVYYMTPEKLATVFSEDQLQKWVGQ-ESKNT---------QLNLLPAFTECTIMQLYNANFMANPDIKLIQIYLIL 232
CCE93637     170 IFCLAVHYMPSKTLHTIFPILPQHELFKPlDHGYDfed----rfQRNLSRCFERCTTTLLLMTNFTANSDIRLIQIYLIL 245
XP_001645691 180 IFALSVYYIDCQQLDALFESDVLSRVLDIsSSPSSraktiteqvQSQLFDFIIKLITVLLYKTNFMTYPDIRLVQIHIIL 259
CAR24189     173 IFTMAIFYMPIELLGKYFPSEQVARLYDS-TPEQAlte----rlRMNLFEGFYRTTVNQLKKADFLRNPVVETIQTYLIL 247
XP_003645686 168 VLTMAIYYIPLNDLSDILKPKMVCEWYNV-HTESTwte----elQYNLYYGFQKATILQLKLANFTAFPDIRIIQTFLIL 242
Q755L4       166 VLTMAVYYMPLSELSSIMDDQPVVDWYGQ-KIPGwse-----elQHGLYYGFLRTALTHLKMADFMSCSDVRIIQIYLIL 239 Eremothecium go...
XP_003955914 183 VFTLSFYYMPVNEISKIFPLEPICEHLNI-DVKQEwte----slQLLIYERYLKVTTTLLMQSDFMNNPNIKFIQVYLIL 257
CCK71869     172 VFSMSIYYIPLSELSELLPSEPLCNWLQI-DVNQGwte----slQLTAYQCFTKCTMVLLKQAEPMSYPDIKLVQIYLIL 246
Q6FTY9       173 IFTMGVYYCPKELLDGIISIDKVRDFTKK-QTLTEeq------iRCKIYEGFITTTIDSLYRCNFMAQPDIRFIQTYIIL 245 [Candida] glabrata
6P7W_A       271 SNTNFLQIYPSLGNNILVHCIHLAKVLGIKDFKLKINDSGSTRLQKLSMHNIWFRLSTVDYMRSSPNKIIALHTDNSSAL 350 Kluyveromyces l...
CAR25751     233 CNTNFNWSNTHLSSTLLILCLHVAKMFHIDDFRSLINDSTAMKLSKLTCEKLWYRLCTYDYLQSSPQRSISCHGEISSLL 312
CCE93637     246 SSTMYPHRRNNSSDSLLLQSFHTAKIKHVNDFKPLISDSAALRLTKVTCEKMWYRLCTCDYLQSSPNKPITFHTELSSLL 325
XP_001645691 260 SATSFLTSHRSLSDSILLQSFSVAKMYQLGNLQRSVNDSTIEQLIKITTEKMWYRLCISDYLSSGPSNRITFHHQISSLL 339
CAR24189     248 AATPFPALEPSLANSLLTQCLHLAKYWRLDQFRPLVTDTPDLRLTKVVCEKLWYRLCVQDFWQSGPNKPLSIHEDNISLL 327
XP_003645686 243 CSTSFVQLDVFFADSLLTQCLHISKFLQIDNFRPMVTDSTSLRLNKLMAQKLWYRLSICDYLQSGPNKKLAIHTENESLI 322
Q755L4       240 SSTSFIQLERSLADSVLVQCIHVAKALQVDQFRPMVSDSAALRLTKLTAQKIWYRLCFCDYLQSGPNKLLCIHTENDSLI 319 Eremothecium go...
XP_003955914 258 SNTTLQINNNTLSDSLLLQCIQVAKFFNIDFHKQYAEDDPFLGISKETFGKIWFKLCIIDYYQSGPAKKIYINNEIPSLL 337
CCK71869     247 TMTTFTYEEPILSNSLILQSTHVAKMFHINFFRQYSEDDLAVGLTKQTFSKLWFKLSAADYLQSGPGKPLEFHTDIPSLL 326
Q6FTY9       246 STTLYSFQFPIQANMILTNAMYVTKLLSATVISASNSEDIIGSIANESLNRLWYRICACDYIQEGPNKSIDFNRELGSLL 325 [Candida] glabrata
6P7W_A       351 TRKTLFThcSIDSIDVYDVESNLEVLRWKITSLDRDLE-----VSEPSLKTLKAMKELLGLLDRKT--------SVSNDA 417 Kluyveromyces l...
CAR25751     313 QHAAYLE--DLPNTDVNQSEDNFEVLYWKLISLDRDLDqylasPTKPPLKTLDAIQRQTEIFQTKIs-------NMVEEE 383
CCE93637     326 QHAAYLE--DLPTTDVYQSEDSFEVFYWKVLSLDRDLDqyltkELKPPLKTLDAVQRQVEIFSRKLs-------SPEEST 396
XP_001645691 340 QQQLPNE--DSSNLDVCQSEDTFDSLFWKILSLDRDIDqylirDSKPPMKTLDAISKFEENLHERVs-------SIGELE 410
CAR24189     328 SHAAYLM--DRPNVDVYQSEDTFEALIWKIVSLDRDLEkyfitTSKPPLKTIDAIQRQIDIFSQKIn-------STDAQA 398
XP_003645686 323 THAAYYE--ELPNVDVYSSEPTFETLLWKLISLDRDLEky--dLRKPTLKSLDAIIRQLDIFSVKVd-------SIEDTE 391
Q755L4       320 THAAYYE--EMPGVDIYQSEDTYETLLWKLISLDRDLEqy--sLKKPSLKSLDAIRRQLDIFTVKLd-------SIDDIH 388 Eremothecium go...
XP_003955914 338 QHAAFYQ--DMPNFNIYKKEDNFESFCWKIVSLERDLDqylvkSFKPQIKTFDAIKRELEIFNKKLdfnkkpkkKSNEIS 415
CCK71869     327 QHAAYYQ--DMPHFNVYENEDDFEVFCWKMFSLDREIDrfldrDIKPQSKTLDAVKRELGIFHTKLnt-----pSDEKKN 399
Q6FTY9       326 KHAAYLE--DLPSTDVYKEEDNYEILFWKLLSLDRDIDqylnnGLKPPPKTLDAVQREVDIYTQKVs------nLEEDQK 397 [Candida] glabrata
6P7W_A       418 SFNTKFESFFLKLQCNFVMWKILRYEFMQYGVTNGLQKLCCPARRIIALVANFLKEDYF-EYTTHPFCVHILCVIAGFFS 496 Kluyveromyces l...
CAR25751     384 SFSSAFEKFLAIFLLRSVCWKLHKMYFIFYDTSDSLTASIHHAKSLIALLVNNVRAKKRiFFNKHPIVLMTFSRVASFYA 463
CCE93637     397 SLDSEFARFLISYLVDGVSWKLHKMFFIYYGISASLGKSIHFAKSLIALVIKNMKLQKE-LFNRHPIVIWSLARVALFYR 475
XP_001645691 411 SKNSQFEKFILIYLLNSISWKLNKSYFIYYDTSGSLEKSMHHVKVMIELLVKNFNHSP--LFNKHPIVINCFSKISLFYS 488
CAR24189     399 STTARCDKFLAGFLLNFVNWKLSNLNYIYYDPHTGAARLNHYTTVLIAQVLHNIKNKLD-FYNRMPLVLRIITKLMTFHT 477
XP_003645686 392 SFSSRFEHFISRLTLNLTYWKVSKLMYVYYRSSTAYDRMKTYTKIIIALILRNIKNHSS-NFNKFPYVSYALSLLMGYHS 470
Q755L4       389 SFNSKFESFQSRLILNLTYWKSCKLFLSYYSSQTSNDQLNTYTEIIIALVLKNIKSNLS-SFNRNPYVLYALSLLLGYHS 467 Eremothecium go...
XP_003955914 416 SINTQFENFLLLFLLNLVSWKLQKMCLIHFETADSLSLSMHYSQNIIQLLIKNVSDGNY-IFNKHPWVLKGLSRIISFYS 494
CCK71869     400 TISSQFERFVSTFLLNSMQWKLQKVYLVYFNTANALELTIHYSQVLIRLLVHNITNGNE-MFNKFPYVLNALGRIVPFYS 478
Q6FTY9       398 SINSKFEKFLGHFILYTVSWKIQKLQIIFYDNKVSLNKLIRITKNIIKLLVKNFEHGHD-TFNKHPLVIYYLSRVATFTN 476 [Candida] glabrata
6P7W_A       497 FYCIFHE-ADEVRDLRNDAVGLLKLLFDPLRPVISCFFSNLSRLEELRHIWKSVEITDQANRLVHPVMYVLKTDIIKLKR 575 Kluyveromyces l...
CAR25751     464 FANIFMQ-KLTVEEIHADLKELLAHLPPTFGYKLENLTYLVDRLDQLKSIWEKIILIDSKNPFQHPIMLILKNDVERIYQ 542
CCE93637     476 FLEMFDS-SAEVQDINLDVSDILHYLPKGFTPHLNELIYLLERLQMLKDMWEYTGDAELRKTFSHPVFRILQSDIDTVSQ 554
XP_001645691 489 FYYTFND-STTLKDLCLDINEVIMNLSDLFKPALSKLIILITRFKKLKLIWDQVKVLDSDNALNHPVITILKDDINFIKK 567
CAR24189     478 LCNVYDD-SATNEQLALDLSEVFAGLGEVSSSLTTPTSKLLDRVRKLKPIWRNVRVVDSESSSNHPVFKILQDDIVFLRD 556
XP_003645686 471 IRNVFSN-SEGNEQLVIDLNELMETASLTVQPSCAAVLEISKRIRKLESIWKTVKVIDNDDPLLHPVFKILQNDIKLVRS 549
Q755L4       468 MKNVFDY-SEQNEQLVVDLRELLKTYLVAFQPTCIKILLVAKRVTKLAYLWKNIRIIDTDDPVQHPVFKILKADIKAVQK 546 Eremothecium go...
XP_003955914 495 YYNIFVE-SPEIEQLYETLSDLLSVLPLLLGKKVNNLKFLIVRLNKLGVLWEKVNVVGSLTGSIHPVFKILQNDIKAITR 573
CCK71869     479 YHSIFFArTARLDQLIEDLKELLNVLPIMLGDKVNKLTFVSARLDALAILWGKVKIVDSGSGVIHPVFKILQNDILFVSK 558
Q6FTY9       477 FYHIFEN-SVEIHEIVLDINELIVNLPPIFGNHLENLKYIIFRFTLLRKEFGKTDVVDTGGEFQHPVFKVLQNDVATISK 555 [Candida] glabrata
6P7W_A       576 N-----LEIISGSLKDANyQETFKDKLEIDINTp--aLSSDFLEVVREFNLSHPLD 624 Kluyveromyces lactis
CAR25751     543 Ilq-rgPSLIRGTGLQSP-KRLFQDDYEFNMDD----NNKEIALIVIEFEKKFDIG 592
CCE93637     555 Qyt-erPSMISGSGP------LRTQKVSSNLEKdtgnISDSYSSLIERFQEQCQFD 603
XP_001645691 568 Sin-hlPPIISGTSSSMLyKRTLDDEDIDAFKGn---KSEAFKLIISEFESEFNIQ 619
CAR24189     557 SctkrlPKFLAAHSS--------KDRLDDGLEAe--pQSREFLQIVANFEKSYPLN 602
XP_003645686 550 Qfn-riPKIFN-----------YGPTVASENEEdt-kEVPEFKAIMKTFEKKYDIL 592
Q755L4       547 Kmn-klPTLLN----------FDTSAIALEDEGet-kESTEFRAIIKEFETQNSFQ 590 Eremothecium gossypii
XP_003955914 574 Anr-kvSVMTNAMHLLGRnDAEEGSGEDEELMLq--tESEEFRLIVSQFEAEHDIS 626
CCK71869     559 Vns-tiPLLVKGVRNIGDnQNIDDQVLASEGDDrdlfESDEFKAIVSTFQSDHNIE 613
Q6FTY9       556 Snn-klNYLLKGLGSLIPgKSIGEGIYEEDEDSm---LDPTILEIVSEFEEKYPID 607 [Candida] glabrata
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