Conserved Protein Domain Family
CBM60

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pfam16841: CBM60 
Ca-dependent carbohydrate-binding module xylan-binding
CBM60 is a family of xylan-binding modules found in conjunction with xylanase enzymes in many bacterial species that attack plant cell walls. Xylan is the major hemicellulose component of most plant cell walls, and is one of the most complex carbohydrates targeted by CBMs. CBM60 modules are evolutionarily related to CBM36 domains as both show circular permutation in the beta-barrel folds. CBM60 targets xylan but is also able to bind cellulose and galactan and thus contribute towards breakdown of the plant cell wall. Recognition of the ligand is conferred primarily through the polar interactions of O2 (oxygen) and O3 of a single sugar with a protein-bound calcium ion.
Statistics
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PSSM-Id: 496147
Aligned: 14 rows
Threshold Bit Score: 87.7735
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_012567734    403 TVKVYAAGNSYrGD--AEFRLLADGQQVGavqdvTTQ--RGTGWQVFTFDLGDGdlgdgdlgdGGlPDRLSIQYANDLYG 478  Rhodospiril...
Q3IXI2          684 TVSVRVSGDAWeGD--PAFALLVNGVVVTpsaivTADr-AAGDWQTLTFTGDWDl--------DG-SDQVGIRFLEDSYA 751  Rhodobacter...
WP_013555331     99 DVRVRARGEQYdGA--PIVALSRGGTPLG-----TATl-DNDSYAMRNFGAVDV---------QP-GQTLTVTYLNDAHG 160  Deinococcus...
WP_013126015     79 TLTVRARADLCkGS--PVATLKAGGAILG-----TIDv-TSSSWATYRVSGTVP---------PG-PNTLTIEYANDYFE 140  Tsukamurell...
WP_012567542    375 AVTVYAAGDDYkGD--PQFRLLLDGKAFGsaqtvTMD--RGDGWQQFKFNLPAG---------TD-PNRISVEYFNDLYG 440  Rhodospiril...
Q7UPC3          270 TLVLSLSGDQG-GDepVRVEV-TDGRRAI-----PVEv-KESEPTDKTVAFRLG---------KG-TRQIDISFLNDYYV 331  Pirellula sp.
WP_013566030    266 VLSIRAWGDQA-GSepVKMGLLVNGQQVK-----VFEvkADRESRAEVFEHQVRt-------rAG-TNKIAIVFLNDFYQ 331  Isosphaera ...
jgi:Plabr_2699  417 TFTVQAQGSQA-GDepARCRIQLDDQKAE-----VHDvpGDRQNKTITWKATLP---------AG-KHALKIAFTNDFYD 480 
Q7UVU2          259 PISIRAAGTTG-SE---QMQLQVGGEVVQtwnniGGDv-ATRQFQTFTYDGAAD---------AT-ADDVRVVFTNDLYQ 323  Pirellula sp.
Q7UTD3           57 gIEVQAIGDTG-QE---ILEVIYNEERIS-----YFRv-S-DQWETYQINVDYTs--------ID-PSLLRIHFVNDFYD 116  Pirellula sp.
WP_012567734    479 GP-----GKDRNLEIDRIEIDGTVIDPGK 502  Rhodospirillum centenum
Q3IXI2          752 GP-----GRDRNLYVDEVRLNGEVNGADR 775  Rhodobacter sphaeroides 2.4.1
WP_013555331    161 GP-----GQDRNAVVDYLTLTPHGAANVP 184  Deinococcus maricopensis
WP_013126015    141 FL-----RCDRNLYVASVTIDDAGAPESC 164  Tsukamurella paurometabola
WP_012567542    441 GK-----GMDRNLEIDKIVVGNQTFDPGK 464  Rhodospirillum centenum
Q7UPC3          332 KD-----KIDRNLHVHHVKVSGVEQRSQf 355  Pirellula sp.
WP_013566030    332 PEt----RSDRNLHVSAIVAKGPLNGPPP 356  Isosphaera pallida
jgi:Plabr_2699  481 PDsenpkRRDRNLYVTASRVEGPKELKRE 509 
Q7UVU2          324 PSq----GIDRNLVVDSITVNGVTVESEN 348  Pirellula sp.
Q7UTD3          117 PAq----GIDRNVQLGSVTIGDQVLDSNA 141  Pirellula sp.
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