6QX9


Conserved Protein Domain Family
SF3A3
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pfam16837: SF3A3 (This model is not part of the current CDD release)
Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9
SF3A3 is one of the components of the SF3a splicing factor complex of the mature U2 snRNP (small nuclear ribonucleoprotein particle). In yeast, SF3a shows a bifurcated assembly structure of three subunits, Prp9 (subunit 3), Prp11 (subunit 2) and Prp21 (subunit 1). Prp9 and Prp21 were not thought to interact with each other but the alpha1 helix of Prp9 does make important contacts with the SURP2 domain of Prp21, thus the two do interact via a bidentate-binding mode. Prp9 harbours a major binding site for stem-loop IIa of U2 snRNA.
Links
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Statistics
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PSSM-Id: 522595
Aligned: 135 rows
Threshold Bit Score: 32.8784
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6QX9_A3      129 EFTDEEGYGRYLDLHDCYLKYINLKase------klDYITYLSIFDQLf--------DIP--KERK 178 human
Q6FNA1       175 IFQKDEQDGFIIDFEPLYRRWLNIVkdg------tlTYPKFISNLEKFidd----kkYLLdpVMDR 230 [Candida] glabrata
XP_003675709 167 YFSREEQYGQYMDFENFYLEWLNVVktg------dvTLLQFLNLLRVFmde----ekYLThpPMDR 222
XP_003671309 181 IFSLEEQYGEYLALNPYYTEWLNVVkke------dlTFLQFLNMLKIFqdd----krYIVqpPMDR 236
XP_003956235 160 TFTRDEQFGECMDLERFHNVWLSVVkdd------sySLLDFFRVIESFldt----ksYLKspHMDR 215
Q757U7       174 LFMWEEHYGEYLFLERLHQDWLNVVkdg------svTLLQFIAFLESFag-----tgYLTapPVDR 228 Eremothecium gossypii
XP_003645840 174 KFSWEEHYGEYLHLDQYHQEYLNIVkna------nvSLLQFIGFLQTFcd-----hgHLKnpPVDR 228
XP_022466722 166 IFNREEQYGTYIQLENYHPMWLELMkep------svTVLQYLESLERMflnaddktsYLTspPIDR 225
XP_003683610 173 YFSKEEQYGEILNLEQFYSSWLNVVkta------dcSILKYILMLNVFldk----deFILnsPMDR 228
XP_013935066   1 MFGPKEALGEILDLSENFKEWLNLPkkqfsygenmpSYADYLSGLTKF---------DCE--TYDK 55
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