Conserved Protein Domain Family
VGPC1_C
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pfam16799: VGPC1_C 
C-terminal membrane-localisation domain of ion-channel, VCN1
VCN1_C is the short C-terminal region of voltage-gated proton channel 1 proteins in higher eukaryotes. The domain is necessary for achieving the dimeric architecture, two monomers form a dimer via parallel alpha-helical coiled-coil interaction. but it is also essential for localising the protein to an intracellular membrane.
Links
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Statistics
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PSSM-Id: 496124
Aligned: 5 rows
Threshold Bit Score: 76.5289
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ELW65529     568 QQLLRLKQMNIQLAAKIQHLEFSCSEKGSLSDchiPLMKLKSSIGLLlqqE 618
XP_031804430 222 RQLSRLRLINHQLATKIQHLEFSCNEKEQEIE---RLNKLLKDNGLL---E 266
XP_028914661 194 QQLSRLRQANLQLVAKVQHLEFSCNEKEQEIE---RLNALLKQHGLI---N 238
XP_016157803 189 QQVSKLKQANLKLATRVEQLEHSCLEKEQEIE---RLNNILKQHGLLiqqK 236
XP_018894192 226 RQLLRLKQMNVQLAAKIQHLEFSCSEKEQEIE---RLNKLLRQHGLLgevN 273
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