Conserved Protein Domain Family
MCM3AP_GANP

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pfam16769: MCM3AP_GANP (This model is not part of the current CDD release)
MCM3AP domain of GANP
MCM3AP_GANP is the C-terminal domain of germinal centre-associated proteins, GANPs in higher eukaryotes. GANP forms part of the TREX-2 complex which in higher eukaryotes requires the MCM3AP domain of GANP to facilitate its localisation to the Nuclear pore complex and nuclear envelope. TREX-2 complex links transcription with nuclear messenger RNA export.
Statistics
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PSSM-Id: 522559
Aligned: 17 rows
Threshold Bit Score: 1030.77
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_028925526  1143 VFPAAPCYVENTNELKALLPSAECPIPKEYFSKGILDLGHAGKLGISCIRLNRLRNEMIHQMKVQYFYQKLLReAAWTPL 1222
1_pfamImport     1 GFPAAPCCVDPRFKLQALAPSAPPTPSVESLAQGYVNLGNSGNMVVSCTRLFKTRNDTFRQMRVNFFYNLLLS-VVWRPL 79  
XP_008112685  1236 AFPAAPCYMDPKDKLKALSPSAESPIAREHLAKRIVNLGHAGNLGTSCLRLGWLRSNTIHQMKVQHFYQQLLRdAVWTPL 1315
XP_030132885  1114 AFPAAPCGLDSKHQLKALSPTAEWPIGMENLCKRFVNLGNGGKLGISCTRLNFLRNKTVHEIKVQHFYQQLVSdLAWTPL 1193
11_pfamImport    1 AFPAAPCCTDPQNKLKALSPSAEWPIAMENLCRKLVNLGNGGKLGISCTRLNWLRNKTVHEIRIHHFLQQLLSdLAWTPL 80  
XP_040057764  1362 GFPAAPCCVDPRFKLRALAPSAPEQTSMADLARGVVNLGNSGTLSLSSTRLLRMREEVIHQMRVHYYYQQLLDeRVWEPL 1441
XP_064419564  1511 VFPAAPAAHDLRCNLQALAPSAS--ITQESLAKGVVNLGHAGSLEVSCTRLLHMRQETIHKMKVQYFYEQLLCdAAWAPL 1588 coelacanth
XP_421891     1079 AFPAAPCCMDPKNKLKALSPSAEWPITMENLCKRIVNMGNGGKLGVSCTRLNWLRNKTAHEIKVQHFYQQLLSdLAWTPL 1158 chicken
XP_056676145  1275 AFPAAPCCVDLSNRLQALSPSAECPIAKENLAKGVLNLGHAGKLGVSCTRLRWMRHRTIHQMKVQYFYQQLLSeAVWTPL 1354 gray short-t...
XP_028924449   638 AFPAAPCCVDQNDRLKALSPSAECPIAEENLARGILDLGNAGKLGVYCTRLRWLRNKAIHQMKVQYFYQQLVSeAAWSPL 717  platypus
XP_028925526  1223 DLPSLISEHLALQREHVFWKVVLVLPDNEMH--PSGDLSRILGNWLKVKFMG--AEISKKVNNNAKDKIQTLALFQYIKQ 1298
1_pfamImport    80 DLPTLVAESTPNPPNRIFWKATLLLPSNEDT--DMSFANSTLTKWLEVKMGGrdKEEEDGSMAEVEGKLETLLISNNLRD 157 
XP_008112685  1316 DLPSLVAENIPVQQEKVFWKALLVLPSYEEY--PAKDPSRILADWLKAKF-Gi-DKNLEEATSVENDGIKTLALHTSLRT 1391
XP_030132885  1194 DLVSLITEHIPVQQEQVFWKVLLVLPSDDEY--SKDDPNRILVDWLKAKFMG--HRSDEKNASHTESKIQTLTLFSSPGM 1269
11_pfamImport   81 DLTSLITEHIPFQQDQVFWKVLLVLPS-DEY--AEDDLNRVLVDWFKTKFIG--DKSWKKNASCTEGRIQTLTLFNSPGM 155 
XP_040057764  1442 DLPALVTENIPNLPDRIFWKAVLLLPSDHES--VATLADRILSDWLEVKLGG--GKGSEVREEQLDGTLQTLCVTNTLRD 1517
XP_064419564  1589 DLPSLIAETFPSPSNRIFWKMILLLPSCEEP--HTNETNRVLAEWLKAKFRG--DGQLEDETTDPEDKLQTLALYSSSRT 1664 coelacanth
XP_421891     1159 DLASLIAEHIPVQQEHVFWKVLLVLPNDDEY--AEDDPNRILIEWLKAKFMK--DKSWKKTASCAEIRIQTLTLFNSSGV 1234 chicken
XP_056676145  1355 DLPALVAEHYPGHREQVFWKLLVVLPDSEEPalG--YSSRVLASWLKVKFMG--SEDLPSRAQQPSDGIQTLTLLNGSAT 1430 gray short-t...
XP_028924449   718 NLPSLIAEHHPGQKEQVFWKLVLVLPESEET--PSGYPSGILSDWLKVKFMG---EVPSGESCGAKDRIQTLALFNSVGY 792  platypus
XP_028925526  1299 QEDWATQVNVCVKVVQGILSDAELETAKSQKDFLGTSGFILLLPV----REKNEDSTKIDEFWFSALLQLRKLLEAKPVL 1374
1_pfamImport   158 VGQRTHKVHICVKVSRGPLTDEGQSQLEEQKELLGTSALLMMLPLlpsaDQSELRQGEEDVPLLAALLQLKQVQEASGWN 237 
XP_008112685  1392 QRDRDIYVSACIKTTHGTLSTSEVEDPGIQKKLLGTSGLILLLSP----RVRSEDVAEEDIYWLSALLQLKRLLQAKPYQ 1467
XP_030132885  1270 QGTRSIKVSVCIKVAHGLLSNSELDLAETQKDLLGTSGLVLLLPP----RVSSEDIAEDDVYWLSALLQLKQLLQAKPFH 1345
11_pfamImport  156 QGSRSINVSVCVKVVHGVLSDSELDAANMQKDLLGTSGFILFLPP----RVRSEDVAEEDVYWLSALLQLKQLLQVKPFH 231 
XP_040057764  1518 EGQRTHKVHISIKASRGPLTEDGLCKTEECCDLQGTGALIVLLPAmpimDPGSDDQ---DVPLLSALLQLKQLQQASAWH 1594
XP_064419564  1665 REGQPVNVHVCIKVACGPLSEDRLDQTESQKDLLGTSGLVMLLLV----GAGGGDVEQEDVYWLSALLQLKQLLQAKPFR 1740 coelacanth
XP_421891     1235 QGSRNIKVSVCVKVVHGVLSDSELDASNTQKDLLGTSGLILLLPP----RVRSEDVAEEDVYWLSALLQLKQLLQVKPFQ 1310 chicken
XP_056676145  1431 KGDRPVWVNVCVKVAHGLLSDSALDATETQKDLLGTSGLLFLLPP----PGKGAEEDEDDTYWLTALLQLKQLLQAKPFH 1506 gray short-t...
XP_028924449   793 RGDRTICVNVCVKVAHGALSDSALDAAETQRDLLGTSGLILLLPP----RIGSEDFAEEDVYWLSALLQLKQLLQAKPFR 868  platypus
XP_028925526  1375 PVIPLIILVPIQGKDEIEKD-VEKGLLLQDLISSELISDYIIVKISSFLNDLEANLQVSK-AVKWLASHSPRHPKLCCQT 1452
1_pfamImport   238 SPLPLALIIPGQPEGAISDEkLEEVLQLKTLVNDGIISEYVFIRVAGSVSDIQGSQQVSDyAVRWLVAHSPASTVLSSQP 317 
XP_008112685  1468 PIVPLVVLVPSRGDEAAEKE-VEEGLMLPDLISANLISGYKVVEIPDSVSDLQGTRKLSE-AVQWLVTQYPSSINLCCQT 1545
XP_030132885  1346 PIVPLVVLVPSQKEKAVEKE-VEDGLMLQDLISAHLISDYTIVELPGSVNDLEGTRRVSA-AVGWLVSHCPASLELCSQT 1423
11_pfamImport  232 PIVPLVVVVPT-AEEAIEKE-VEEGLMLQDLISAQLISDYIIVELSGSINDLQGSKRIAA-AVGWLVSQCPNSLKICSQT 308 
XP_040057764  1595 CPLPLAILVPGTECANGDVQkLEEALMLHTLVQEGMISEYTFYFIPETTSDLQGSKQLSQ-ATRWLLARAPPPFPLSCQT 1673
XP_064419564  1741 PAVPLLILFSPQGEEAVSKDqVEEGLMLQDLVAAKLISEYHIVEMPGLMTDLHGANRVSQ-SVKWLVSHCPSSVALCSRT 1819 coelacanth
XP_421891     1311 PIVPLLVLVPSQEEEATEKE-VEEGLMLQDLISAQLISDYMIVELAGSINDLEGTRKISA-AVSWLVSKCPNSLELCSQT 1388 chicken
XP_056676145  1507 PLVPLAVLVPSEEGAAE-AE-VEEGLMLPDLVSSQLISDYVVMGIPASVSDLQGTHRVSQ-AVKWLVSHCPSSLELCCQT 1583 gray short-t...
XP_028924449   869 PVVPLVVLVPNRGGDTGERE-VEEGLMLQDLVSAKLISDYIIVEIPDSVSDLRGTNRVSA-SVKWLVAHCPGSLELCCRT 946  platypus
XP_028925526  1453 LSQFVEDGVHREFSRRFFWDRKERRLAGLASQKPGPIIDLYNSVLQFLADVISSEWLSNLSWPVPEFAEPEGTGQLPHLY 1532
1_pfamImport   318 LVQFVESGLCREFHTRFHRDKQERMQAGLMCQDSTAIIQLYNSVLCYLADLVSCEQMIGISWPPPEFSLPENRDLVPHLD 397 
XP_008112685  1546 LRQYVEDGLDLLFSQQFYLDRKERYTAGLCAQDPSAVIELYNNAVQFLAEVVSSEDLYDLSWPVIEFAEPGGSKLLPHLQ 1625
XP_030132885  1424 LQEYIEDGIDGEFGKRFYHDWKERRLAGLPSQEPGVIIELYNSVLQFLSDVASSEHFYDLSWPVTEFSEAGGNKMLPHLQ 1503
11_pfamImport  309 LQEYIEDGIDGEFGKRFYLDWKERRLAGLPSQEPGAIIELYNSVLQFLSDAASSEHLCDLSWPVTEFSKPGGNKLLPHLQ 388 
XP_040057764  1674 LVQLVEASLSREFSPRVHAHRQERVAARLPSQSPVPVIQLYNSVLAHIADKVSSRDLGKLSWPPGEFCLHDTREFIPHLG 1753
XP_064419564  1820 LLQYLEDGLCNEFNDRFYTDKIERQVAGLPSQDPHAVIELYNSVLDFLAEVASSEELCDLSWPISEFVGPGSSETFPHLQ 1899 coelacanth
XP_421891     1389 LQEYIEDGIDGEFGKRFYHDWRERRLAGLPSQEPGVIIELYNSVLQFLSEVASSEHLCDLSWPVTEFSEPGGNKLLPHLH 1468 chicken
XP_056676145  1584 LPQYIEDGVSREFSDRFFYDRKERRLAGLASQEPSAIIELFNSVLQFLAGVAASEHLCHLSWPITEFAEPGGNKVLPHLQ 1663 gray short-t...
XP_028924449   947 LLQFVEDGLSFEFSDRFFHDRRERRLAGLPSQEPGAVIELYNSVLQFLATVASSERLCDLSWPVTEFAEPGGSELLPHLR 1026 platypus
XP_028925526  1533 WNTPRHLAWLKEAVLSFQIPQIDIPP-SAPWNFICTTIFQYISQIPSSHQTQPVLQVQVENLLSGIYFKLKDKELAS--- 1608
1_pfamImport   398 WNSPQHLAWLKRTVLSLQIPEWDQPPiNASWPHLCTSIFHYVSQIPSSPQSQPLLMSRLEHLLARVRAQHMQDGREDee- 476 
XP_008112685  1626 WNMPKHLSWLRKAVLSFQIPHMDLPPsGAPWHLVCAMIFQYVSQTASSPQSQEILQSQIENLLSRTYLKWKDKKSMQ--- 1702
XP_030132885  1504 WNMPDHLAWLRKAVLSFQIPYLDLPPlGAPWHPVCHMIFQYVSQIASSSHTQPLIQSQVENLLSKTYQNWKTRTTGN--- 1580
11_pfamImport  389 WNMPDHLAWLKKAVLSFQIPYLDLPPlGAPWSPVCHMIFQYVSQIANSSHTQPLIQSQVENLLSKTYQKWKNRTLGS--- 465 
XP_040057764  1754 WNSAQHQEWLREVILSLQLPQWEQLCtTDSWSALCSSIFRYAAQIPVSQRSQPLLMSRLENILERVRLKSLHTRTRAsna 1833
XP_064419564  1900 WNTAEHLAWLRKAVLSFKLPEMDRLIvQAPWNAACRSISQYVSQIATSLHTQTMLISQVECLLNRVYTRWMDSEAAA--- 1976 coelacanth
XP_421891     1469 WNVPDHLAWLKKAVLSFQIPYLDLPPlGAPWRPVCRMIFQYASQIASSSHTQPLIQSQVENLLSKTYQKWKNGPLGN--- 1545 chicken
XP_056676145  1664 WNAPDHLAWLKKAVLSFQLPHMDLPPqGAPWRPVCTMISQYVSQIPSCRQTQPILQSQVENLLSRTYARWRNKELWA--- 1740 gray short-t...
XP_028924449  1027 WNTPDHLAWLKKAVLSFQIPQMDLPPlGAPWRPVCSMIFQYVSQIPSCRQTQPILQSQVENLLSRTYSEWKRKVPAS--- 1103 platypus
XP_028925526  1609 ------SGEGGFSVKDIPWDAIISLCINHRLKDWMPLTLPTVSEALSRDGEIRVYFSKDHLSEFTRPSSWERAR-----L 1677
1_pfamImport   477 ----dtDEKAGPSFSRIPWDDILFLCIEHRMKDWSLPESPVTEDAFTDSGEILVYYIKKQVMDFMPPESWVTAV-----K 547 
XP_008112685  1703 ------SSKDGPSVEEIPWDSMLALCINHKLRDWKPPCLPVAPEAVNEDGQIHVYFFKEHLGRFGCPFSWEEAR-----L 1771
XP_030132885  1581 ------SDEDGPSVDEIPWDCILAVCIDHKLRDWKPPKLPVAPEAISKDGQIRVYFFKGHLENYSVPFSWDQAR-----L 1649
11_pfamImport  466 --------SDGPSVDEIPWDAILAVCIDHKLRDWKPPKLPVAPEAVSEDGQIRVYYFKEHLQNFAIPYVWEQAR-----L 532 
XP_040057764  1834 amsnwnEESACPAFSQVPWDDVVVICIDHKLKDWQIPGLPICEDAVTDDGEILVYLPAESLKGFQPPEEWTEAT-----R 1908
XP_064419564  1977 ------WGDNGPSAQEIPWDDLLTLCINHRLRDWKPPGSPLESDALSEDGQVFVYF---------VEEDLKKYKhlsswE 2041 coelacanth
XP_421891     1546 -------SGDGPSVDEIPWDDILATCIDHKLRDWKPPKLPVAPEAVSEDGQIRVYFFKEHLKNFTLPFSWEQAR-----L 1613 chicken
XP_056676145  1741 ------LGETGPSVDDIPWDDILALCINHKLRDWKPPRLPVTSEALSDDGQICVYFFKSHLKNYNVPSSWEQAR-----L 1809 gray short-t...
XP_028924449  1104 ------SGESGPTVEEIPWDDVLALCINHRLRDWKPPKPAVSSEAVSEDGQICVYFFKEHLKKYQLPLSWEQAR-----L 1172 platypus
XP_028925526  1678 RTQREIQ-QSYE--RSVSDSNQSSKPNDGLGMTVERNDGRGRVTPgkkkeylpvEASDPSFSREELLSAHLSTCLQQERE 1754
1_pfamImport   548 LTHKQKQkNLNGskESPVVASSPSAHFPRQRLFQSRIEPEESPTA---------LDITHSLSPQELLPHRLLASIQQEKA 618 
XP_008112685  1772 KTQKMSQ-QSQG--RSKIKTT-SFARLYSPSLSPAEFWASEGKARnteltvpsgADLTVTVSEIDALPECLSVKLQQEKA 1847
XP_030132885  1650 RTQEEIR-QGHE--RSKIKYPKSYKKPYSFSMVPGQYDSGMLPRQevsv--pstDEFRDTSLAQEHL----LAQLQLEKI 1720
11_pfamImport  533 RTQEEIR-QGNE--RSRIKSTVSFKKPCSVSMMPEQNGAGMSMLLsqgrsipsaDPLTDTTSARDLLPERLLRQLQQEKM 609 
XP_040057764  1909 QTHRQKQqETDG--ADAAACATPSSLSLRQRLFSSLVEPLEDPAAr--------LDITHTPTAPELVAHKVFRILEKEKA 1978
XP_064419564  2042 RARLRTQrENQQa---pTRQQKQPSRLALRSHVACR--SVMDFTKaletrspsvVDSAHTPSAQNLSPQCLDDTFEKGEE 2116 coelacanth
XP_421891     1614 RTQEEIR------------------------------------------------------------------------Q 1621 chicken
XP_056676145  1810 QTQKGAPrHDQG--RLGTKSSRSPAKGFSSPWLQVPHSRPRGPENgrvgrvpdaKELTHTASAEELLPERLSASLQLEKE 1887 gray short-t...
XP_028924449  1173 QTKKEIQ-QSQG--SLGIKSPESSARKCAPSLLQMPFNVIRKPGNgkegripsaEELIHTASAEELLPERLTSGIQLEKE 1249 platypus
XP_028925526  1755 ESK------KFEDQIQQWLTEDPgqlK--VSLPqqftpvnLLQPVALgVNTPALIE-----------L---------QVS 1806
1_pfamImport   619 QSQsfwcvfRFEEQLQRWLEVDP---LdsVSMP-------LFMPSTL-LCVPEILTpsrrpaasadtE---------SDD 678 
XP_008112685  1848 ESR------RFDERLQQLLVQDSeifQdsPSLP-------LYLPETL-VCVPQIIQplakp-smaksP---------EAG 1903
XP_030132885  1721 ENK------RFEEQLHQYLAEDMeplEdlLGLP-------LYLPQSL-LSTPAATCplvks--pmsaA---------QEA 1775
11_pfamImport  610 ESR------RFEEQLQQCLTEDTeplGdfMGLP-------LYLPQSL-VSTPAISGplirs--smspV---------QGA 664 
XP_040057764  1979 ESK------RSMEQLQRWLDGDS---LdyLSTP-------LFVPSSTlLSTPTAIMcapsavvtqepE---------QDH 2033
XP_064419564  2117 ESH------RLQKKpsystpeslvarrsltaikkslemelssiadithtlsaeellpqrlqdsiekekkesekfeeqlqq 2190 coelacanth
XP_421891     1622 DHK------Rsrvkspvsfkkpcrvfmtdqygaganilsgqgrnissadeltasaqdlperlltqlqlekmesrrfeeql 1695 chicken
XP_056676145  1888 ESK------RFEDRLRQWLAGDLepgAdaSSLP-------LYLPQAL-VATPQTLQpvl------rmVaaaaapavpQDE 1947 gray short-t...
XP_028924449  1250 ENK------RFEDKLHQWLAEDSvqlAdsTALP-------LYLPQAL-VSVPQAIRppses--prtsP---------QNA 1304 platypus
XP_028925526  1807 RQMENTR-SMQEPSTSLSKRLRHLENLIRATREEDRVFDLQLSTLRD 1852
1_pfamImport   679 FAEKVPSsCRRDTPVSLTQRLEELDRLIKANREEELACSLKLKGLLE 725 
XP_008112685  1904 KK------ELPDPDTSLSHRLQYLKQQIRANKEEEIACETHLSTLLD 1944
XP_030132885  1776 GSQEKHKiPEMEQSSALSDRLKHLQQLLRATKEAEAASELHLSALVD 1822
11_pfamImport  665 GSQAGCElLEDNLSPILSDRLKHLQRLLRANREGEVASELHLSTLMD 711 
XP_040057764  2034 LSDKADR--SKTKPLSIEWQLKELKRQILASHEEELACRLKLSGLLN 2078
XP_064419564  2191 wlsedplkqsfpfpvylpqslvsipeaipvpfrtspsadlqgknrsk 2237 coelacanth
XP_421891     1696 hqylaedteplgdlvgfplylpqslistptlagplikspmssvqvdg 1742 chicken
XP_056676145  1948 ESAEQPP-PSPEMDASLTEKLRRLESLIERTKEEELACERHLSTLLD 1993 gray short-tailed opossum
XP_028924449  1305 GAAERKRtAAPDEDLSLSDRLKHLERLIKSTKEEEIACERHLSTLLD 1351 platypus
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