Conserved Protein Domain Family
NupH_GANP

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pfam16768: NupH_GANP 
Nucleoporin homology of Germinal-centre associated nuclear protein
NupH_GANP is the nucleoporin-homology domain at the N-terminus of human GANP or germinal-centre associated nuclear proteins. GANP is part of the TREX-2 complex that links transcription with nuclear messenger RNA export, and it associates with the mRNP particle through the interaction of the NupH_GANP with NXF1, the export factor. This attachment mediates efficient delivery of mRNPs to nuclear pore complexes.
Statistics
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PSSM-Id: 496101
Aligned: 9 rows
Threshold Bit Score: 224.788
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_051715463    2 NPPNPFSGQQPSAFPTSASgSIGTFQAKPPFRFGQPSLFGQNNTLs--GKNSGFSQASSFPAASGVSHSSSVQTLGFAQT 79  
XP_003500597    2 NPVNPFSGQQPGAFAVSSS-TTGTYQTKSSFRFGQPPLFGQNNTL---GKSLGFSQVSSFATPSVVSHSSSLPTFGVTQT 77  
4_pfamImport    1 NPVNPFIGQQPSAFAASSSgTAGTFQSKPPFRFGQPSLFGQNNTLs--GKSPGFSHMPSFGTPSGITHSSG-QTFGLTQT 77  
XP_030662199    2 NPTNPFSGQQPSAFSASSS-NVGTLPSKPPFRFGQPSLFGQNSTLs--GKSSGFSQVSSFPASSGVSHSSSVQTLGFTQT 78  
XP_008112685    2 NPNTPFSGQQPGGFQVPSGpATGIFPAQPSFQFGQPPIFGQNTGSgalLKNPGFTHLTDFTVTAGA-RSS----LSLGQT 76  
3_pfamImport    1 NPNSLFGGQQSSMFSSTSG-SLGTFQVQPPFRFGQPSLFGQSALGa--GQN--------FAQTSGGTQSSSGSTLGFPAN 69  
XP_056676144    2 NSNNPFGGQQSSLFSTPSGaSLGTFQVQPPFRFGQPSLFGQNNVGs--GQNVGFAQTSGFAQAAGVGQAPSGATIGFPPT 79  
1_pfamImport    1 NPTNPFSGQQPGVFPASTSsSIGTFQAKPPFRFGQPSPFGQNNTLs--GKTSGFSQVSSFPTSSGVSHSSSAQTLGFSQT 78  
2_pfamImport    1 NPPNPFSGQQPSAFLTSSSsSIGTAQAKQPFRFGQPSLFGQNNTVs--GKSSGFSQISSFPT-SGVGHSSSAQTLGFSQT 77  
XP_051715463   80 SSAGLFSG-LEHTPTFAATSGPSSSSVPANPGFSFKSSTNLEVFPSTSTFGPEGGELPGSGFGKTEFTFKPLENAVFRPI 158 
XP_003500597   78 SSVGLFAT-LESTPSFAATSGPSSSSVPGNTGFSFKSPSSVGVFPSGSTFGPETGEVASSGFRKTEFKFKPMENAVFRPI 156 
4_pfamImport   78 SSSGLFSG-LERAPPFVATSGPSSSSVPGNPGFSFKSPTSLGVFSSTTAFGSEAGEVVSSGFGKTEFSFKPLENAVFRPI 156 
XP_030662199   79 SSVGPFSG-LEHTSTFVATSGPSSSSVLGNPGFSFKSPTSVGAFPSTSAFGQEAGEIVNSGFGKTEFSFKPLENAVFKPI 157 
XP_008112685   77 PGFAQSYT-AAPTTSFVTSA-PTYSSVPSKQAFSFKPPTALGPSHCPPNFGATSTDTSGSGFVGPDFSFKTPENAVFKPI 154 
3_pfamImport   70 SGIGSHSVpPPQAPVFTAASGPPSTSAPSNAGFSFKTPPNIGAFPSTPSFGHGSGE--ASGLGRSEFSFKPPESATFRPI 147 
XP_056676144   80 SGLGLYPT-QGQAPALTATSGPPGSSVPSNPGFSFKPPTNLGAFPGTTSFGLSSGETASCGLGRPEFSFKPPESATFRPI 158 
1_pfamImport   79 SNAGLFPG-LEHTPAFVAASGSSSSCVSANPGFSFKSP-SFGAFPSTSTFGPETGEVASSSFGKTEFSFKPLENSVFRPI 156 
2_pfamImport   78 SNVGLFSG-LEHTPSFLSASGPSSSCVPGNPGFTFKSP-NLGAFPSTSTFAPETGEVASYGLGKTEFSFKSLENSVFRPI 155 
XP_051715463  159 LANESEPEKTQSQITSGFFTFSHPISSGPGGLAPFSFPPVTSSSTTNSNFTFSKPVnTNNSSSAFAPALSGQNAEEEKRG 238 
XP_003500597  157 LGAESEPEKTQSQIASGFFTFPHPVSSGSGSLTPFSFSQVTNSSVTSSNFVFSKPA-NSNTTSVLTPALSNQNVEEEKRG 235 
4_pfamImport  157 LGTESEPEKTQSQITSGFFTFSHPVNSGPGGPTPFSFSQVTSSSAPNSSFIFSKPVnSNNSSSPFNPALSNQNVEEEKRG 236 
XP_030662199  158 LGAESEPEKTQSQIASGFFTFSHPISSAPGGLAPFSFPQVTSSSATNSNFTFSKPVsSNNSLSAFTPALSNQNVEEEKRG 237 
XP_008112685  155 FGTGSGQEKLANTGNQPSFTFSSPGTSGSGRLAPFAMSQASSSTA-STSFSFSKPLsSNTSASSFSVALPSKTTEDDKKR 233 
3_pfamImport  148 FGAESEPEKTQSQITPGSFTFSHPVSGGPEALVSFTFSQGSSSSGTSPSFTFSKPA---SNSSTF--ASASQNVEEEKRG 222 
XP_056676144  159 FGAESESEKTQSQVTPGSFTFSHPVSSGPEALGSFTFSQGSSGAGTGPNFTFSKPS-GNTPSSAFASASSGQNSEEEKRG 237 
1_pfamImport  157 FGAESEPEKTQSPVTSGFFTFSHPISSGPGGLAPFAFPQVTSSSAANSNFTFSKPVnSNNSSSAFTSALPNQNVEEEKRA 236 
2_pfamImport  156 LGAESEPEKTQSQITSGFFTFSQPISSGPGGQAPFSFTQVT-SSATKSNFTFSKPVdSSNSSSPFALALSSQNVEEEKKG 234 
XP_051715463  239 SKSGFGSCNSSFSSFPM-SSVSGGESFPVSKTGVRQGCEEAVSQVEPLPSLMKGL 292 
XP_003500597  236 PKSVFGSSNSSFTTFPMpSSASLGEPFSGNKTVIRQGCEEAISLVEPLPTPMKGL 290 
4_pfamImport  237 PKSVFGSCNSNFSSFPV-SSGSLGEPFSVNKSGVRQGCEEAVSQVEPLPGLMKGL 290 
XP_030662199  238 PKSIFGSSQNSFSSFPV-SSAVLGEPFQASKAGVRQGCEEAVSQVEPLPSLMKGL 291 
XP_008112685  234 PTVFFASPSSSFTSFSNsSTGSLLDPFQMNKTAKLQH-EEIVAPVEPHSLFGKGT 287 
3_pfamImport  223 PKPAFGSSGSSFTSFA--SPGSVGEPFSMSKAVGKLGRDDAGGQGGLLSGHVKGL 275 
XP_056676144  238 PKPAFGSAGSSFTSFAGsLPGSVGEPFALSKAASKQGRDDLGGQGGSLPGHMKGL 292 
1_pfamImport  237 PKSLFGSSDSSFTNFPI-SSGPLGEPFPVSKTGVRQGCEERVSQMEPLPSLMKGL 290 
2_pfamImport  235 PKSLFGSLNSSFTSFPTsSSGSLGEPFPVSKTGARQGCEETVSQVEPLCSFMKGL 289 
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