5IZ2,6QJY,2N3E,2MX8,6TV5


Conserved Protein Domain Family
Spidroin_N
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pfam16763: Spidroin_N (This model is not part of the current CDD release)
Major ampullate spidroin 1, spider silk protein 1, N-term
Spidroin is produced by a number of arachnids. Spidrions are made up of repetitive segments flanked by conserved non-repetitive domains, and this domain is the conserved non-repetitive region. Aggregation to form the rigid silk occurs due to association at the repetitive regions, and the N-terminal domain is necessary to prevent premature aggregation during storage before extrusion. This N_terminal region inhibits precocious aggregation and then accelerates and directs self-assembly as the pH is lowered along the extrusion duct.
Links
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Statistics
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PSSM-Id: 522555
Aligned: 26 rows
Threshold Bit Score: 118.173
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5IZ2_B         14 PWSSTELADAFINAFMNEAGRTGAFTADQLDDMSTIGDTIKTAMDKMARSNKSSKGKLQALNMAFASSMAEIAAVEqg-- 91   Trichonephila...
ADM14317       23 PWETPEMAENFMNNVRENLEASRIFPDELMKDMEAITNTMIAAVDGLEAQHRSSYASLQAMNTAFASSMAQLFATE---- 98  
4_pfamImport    1 PWANPAKANAFMKCLIQKISTSPVFPQQEKEDMEEIVETMMSAFSSMSTSGGSNAAKLQAMNMAFASSMAELVIAEdadn 80  
ADM14330       39 IFGNPNTANNFVDCLKGGIQASPAFPRQEQADIQSIASSILSA----GNTATKSKAIEQALSTALASSLAEIVITEsg-- 112 
Q1KXY8         33 IFNSPNAATSFLNCLRSNIESSPAFPFQEQADLDSIAEVILSDVSSV---NTASSATSLALSTALASSLAELLVTEsa-- 107  western black...
Q2V0S3         35 VFSSPSLASGFLGCLTTGIGLSPAFPFQEQQDLDDLAKVILSAVTSNT--DTSKSARAQALSTALASSLADLLISEss-- 110  Nephila clavata
Q25C18         30 VFSSPNLASGFLQCLTFGIGNSPAFPTQEQQDLDAIAQVILNAVSSNT--GATASARAQALSTALASSLTDLLIAEsa-- 105  Argiope bruen...
ADM14328       20 IWGTPGAGKSVTGSIVQCAGQSGVFSGDQMQDLGDMADAVNRQLDRLG--PNAPDHRLKGVTTMMAAGIADAAVNSpg-- 95  
ADM14326       18 VWSSPQMAENFMNGFSMALSQAGAFSGQEMKDFDDVRDIMNSAMDKMIRSGKSGRGAMRAMNAAFGSAIAEIVAANgg-- 95  
ADM14315       32 PFANKIMAEDFMNKFTNQLANSPYFSSQQKEDMSSIKDELISVIESMDSAHKSSAAKLQAMNMAFASAIADIAATEay-- 109 

5IZ2_B         92 glSVDAKTNAIADSLNSAFYQTTGAANPQFVNEIRSLINMFAQ---SSAN 138  Trichonephila clavipes
ADM14317       99 --QDYVDTEVIAGAIGKAYQQITGYENPHLASEVTRLIQLFREeddLENE 146 
4_pfamImport   81 pdSISIKTEALAKSLQQCFKSTLGSVNRHFIAEIKDLIGMFAR---EAA- 126 
ADM14330      113 gqDYSKQITDLNGILSNCFIQTTGVENKRFVNSIQNLIRLLAE---SAVS 159 
Q1KXY8        108 eeDIDNQVVALSTILSQCFVETTGSPNPAFVASVKSLLGVLSQ---SASN 154  western black widow
Q2V0S3        111 gsSYQTQISALTNILSDCFVTTTGSNNPAFVSRVQTLIGVLSQ---SSSN 157  Nephila clavata
Q25C18        106 esNYSNQLSELTGILSDCFIQTTGSDNPAFVSRIQSLISVLSQ---NADT 152  Argiope bruennichi
ADM14328       96 -qSLDVMINTISGCMTQAMSQAVGYVDQTLIREVAEMVNMLAN---ENAN 141 
ADM14326       96 ---kEYQIGAVLDAVTNTLLQLTGNADNGFLNEISRLITLFSS---VEAN 139 
ADM14315      110 gaDISLETSAIANALSEAFLQTTGVVNKRFISEIQELIYMFAQdasVQSN 159
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