3VNC


Conserved Protein Domain Family
Tipalpha
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pfam16753: Tipalpha (This model is not part of the current CDD release)
TNF-alpha-Inducing protein of Helicobacter
Tipalpha is secreted from H. pylori as dimers and enters the gastric cells. It binds to DNA via the positively charged surface-patch formed between the two monomers of the crystal structure by the loop between helices alpha1 and alpha2. Each monomer consists of a helical domain and a mixed domain.
Links
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Statistics
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PSSM-Id: 522548
Aligned: 3 rows
Threshold Bit Score: 119.833
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3VNC_A         8 QRNSFLQDVPYWMLQNRSEYITQGVDSSHIVDGkKTEEIEKIATKRATIRVAQNIVHKLKEAYLSKTNRIKQKITNEMFI 87  Helicobacter py...
WP_013889711  29 EKRVFLQNMPRWMIEDQSMYINRGIDSSHVIDG-QVARSEGIARERARFRVAIHIANKIKEFYKQSQNAHQKPYDDAIFT 107 Helicobacter bi...
O25318        32 QRNSFLQDVPYWMLQNRSEYITQGVDSSHIVDGkKTEEIEKIATKRATIRVAQNIVHKLKEAYLSKTNRIKQKITNEMFI 111 Helicobacter py...

3VNC_A        88 QMTQPIYDSLMNVDRLGIYINPNNEEVFALVRARGFDKDALSEGLHKM-SLDNQAVSILVAKVEEIFKDSV 157 Helicobacter pylori 26695
WP_013889711 108 QITQAIAASLDQEIQLGEYINPNNQEVFMLVRVDGYQPARLERLLFNIkALDVATVRLILAKVQAIFKAAL 178 Helicobacter bizzozeronii
O25318       112 QMTQPIYDSLMNVDRLGIYINPNNEEVFALVRARGFDKDALSEGLHKM-SLDNQAVSILVAKVEEIFKDSV 181 Helicobacter pylori
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