4H8S,5C5B,4NSW


Conserved Protein Domain Family
BAR_3
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pfam16746: BAR_3 (This model is not part of the current CDD release)
BAR domain of APPL family
BAR_12 is the BAR coiled-coil domain at the N-terminus of APPL or adaptor protein containing PH domain, PTB domain, and leucine zipper motif proteins in higher eukaryotes. This BAR domain contains four helices whereas the other classical BAR domains contain only three helices. The first three helices form an antiparallel coiled-coil, while the fourth helix, is unique to APPL1. BAR domains take part in many varied biological processes such as fission of synaptic vesicles, endocytosis, regulation of the actin cytoskeleton, transcriptional repression, cell-cell fusion, apoptosis, secretory vesicle fusion, and tissue differentiation.
Links
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Statistics
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PSSM-Id: 522543
Aligned: 42 rows
Threshold Bit Score: 214.743
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4H8S_A         30 LLLEEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYEKQNfalgK----GDEEV 105  human
NP_741164       6 LEFSDSISDSPWFRQNLHDHEVALDDAFKNIKLIENQCKELIACTKKLSTAQRAFAKTLSEFKFET----V----GTNQT 77  
EEC20555        6 LEFTDCLTDSPYFRENLHAHENELDRTSQAIKGIIKEVKELLTAAKSLSRAQRSLANTFMNFRLEC----I----GNSQT 77  
XP_046449086    6 LEFTECLTDSPYFRENLQGHEKELEKTSLAIKVLIKEVKDLVNAARALSRAQRSLATSLMSFQFEC----I----GNSQT 77  
Q8K3G9          7 LLLEEALQDSPQARSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSRQLLAYEKQNfalgK----GDEEV 82   house mouse
XP_005174316    8 LLLEEALQDSPQTRSLLSVFEEDAGTLTNYTNQLLQSMQRVFGAQNEMALATEQLSKQLLEYEKQNfalaK----GDEEV 83  
5C5B_A          7 LPIEETLEDSPQTRSLLGVFEEDATAISNYMNQLYQAMHRIYDAQNELSAATHLTSKLLKEYEKQR----FplggDDEVM 82   human
XP_003967675    8 LLLEEALQDSPQTRSLLSVFEEDSGMLTNYTNQLLQALQRVFGAQSEMGLATEQLSQQLLEYEKKNfalgK----GDEEV 83   torafugu
XP_064417874    7 LLLEEALQDSPQTRSLLSVFEEDAGTLTEYTNQLLQAMQRVYGAQNEMCLATQQLSNQLLAYEKQNfalgK----GDEEV 82   coelacanth
XP_026693007    6 LEFSDCFLDSPFFRKSIQEYEDELERTNSQIKQLIKDAKNMLNASRQQGKMMNVFNDRLQNFQFDC----I----GENLT 77   vase tunicate

4H8S_A        106 I------STLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTE-VSTLKDLFGLASNEHDLSMAKYSRLPKKKE 178  human
NP_741164      78 DderfiaTCLKEFGSLINQVEDERMKLVGQAEESYLEPIKKFRTEAIGRtLKEEKNKYDKESSKFYQTLEKHLHLSTV-R 156 
EEC20555       78 DdeiviaGSLKEFGRLLTTIEDERDRMLENAHELFIAPIEKFRKDHIGE-AKERKKKFDKETAKYCQSLERYLGLSTKKG 156 
XP_046449086   78 DdeiviaGSLKEFGRLINAIEDERDRMLERAKDQFIGPLENFRKEHIGG-AKEEKKKFEKQTAKFVQSQERHLNLSTKKQ 156 
Q8K3G9         83 I------STLHYFSKVMDELNGLHTELAKQLADTMVLPVIQFREKDLTE-VSTLKDLFGLASSEHDLSMAKYSRLPKKKE 155  house mouse
XP_005174316   84 I------NTLQQFAKSVEELNALHSELSTQIADKMVFPMVQFREKDLTE-ISTLKEIFSIATDEHEAAMVKYSRLPKKRE 156 
5C5B_A         83 S------STLQQFSKVIDELSSCHAVLSTQLADAMMFPITQFKERDLKE-ILTLKEVFQIASNDHDAAINRYSRLSKKRE 155  human
XP_003967675   84 I------STLQNFAKSVGELNSLHSELATQMADSMVFPLIQFREKDLTE-VSTLKEIFGIATDEHEAAMVKYSRLPKKKE 156  torafugu
XP_064417874   83 I------STLQHFAKVVDELNALHTELTRQLADKMVLPIIQFREKDLTE-ISTLKDLFVLSSNEHDIAMAKYSRLPKKRE 155  coelacanth
XP_026693007   78 DtekgiaGSLKEFGLMLEEVANDWSSTIERSELQLIKPLEDFRKEHIHS-YRSSKKAFDKASERYYKQLEQTLALSHKKK 156  vase tunicate

4H8S_A        179 NEKVKtEVGKEVAAARRKQHLS-SLQYYCALNALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFsKR-MDSFLSSVADMV 256  human
NP_741164     157 NNDFR-AADAQLETQQKNFFQA-SLQYVAEVQSVQERMRFEFVETLGSYVYSWLSFFHVGSVIH-QD-FKPFLDNVQTKV 232 
EEC20555      157 DTQLK-EAFAVLEMEKRHFFKA-SLEYVLMLQKVQERKKTEFVETILRFMYGWLTFYHQGHEVA-KE-FNSFNTDLQVRL 232 
XP_046449086  157 DSVLQ-EADAILEMEQRHFCQA-SLEYVYRLQEVHERKKFEFVETLLGFMYGWLTFYHQGYEVS-KE-FRPYMTDLQVRL 232 
Q8K3G9        156 NEKAKtEIVKEVAAARRKQH-LsSLQYYCALNALQYRKRAAMMEPLIGFAHGQINFFKRGAEMFsKS-MDGFLSSVKDMV 233  house mouse
XP_005174316  157 NEKVKaEVVREVAYSRRKQHQA-AMQYYCALNALQYRKRVAMLEPMLGYTHAQINFFKKGMELVsKK-LDSFLN----SV 230 
5C5B_A        156 NDKVKyEVTEDVYTSRKKQHQT-MMHYFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENL-NEqLEEFLANIGTSV 233  human
XP_003967675  157 NEKLKsDMMKEVAYTRRKLHQA-SLQYYCALNALQYRKRIAMLEPMLGYTLAQIGFFKKGIELVsKK-MDSFLNSVSNMT 234  torafugu
XP_064417874  156 NERLKaGVVAEVADSRRKQHLS-SLQYYCSLNALQYRKRVAVIEPMLGYTEAQVNIFKKGMETFsKR-MEDFLSSVSNMI 233  coelacanth
XP_026693007  157 CQQLQ-ESDNELFTHKKTFHKE-ALNYVYKLQEVQERKKFEFVEHLLMFMQVYFNFFHQSHETA-ND-CKDYMKELQIRL 232  vase tunicate

4H8S_A        257 QS--IQV---ELEAEAEKM 270  human
NP_741164     233 QK--TKEnynATNAEAEEL 249 
EEC20555      233 QKasTREnfeATHCEAEHL 251 
XP_046449086  233 QK--TREnfnTTREEAESL 249 
Q8K3G9        234 QS--IQV---ELEAEADKM 247  house mouse
XP_005174316  231 SN--MNEsieSQLEIDAEV 247 
5C5B_A        234 QN--VRR---EMDSDIETM 247  human
XP_003967675  235 QN--IQA---QLDVEAEAM 248  torafugu
XP_064417874  234 QS--IQR---QLDEETEAM 247  coelacanth
XP_026693007  233 VS--TRAqydGTREKTKTL 249  vase tunicate
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