4NOA


Conserved Protein Domain Family
ComP_DUS

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pfam16732: ComP_DUS (This model is not part of the current CDD release)
Type IV minor pilin ComP, DNA uptake sequence receptor
ComP-DUS is the DNA-uptake sequence receptor of pathogenic Proteobacteria. ComP is a type IV minor pilin -site on the minor type IV pilin, C one of three minor (low abundance) pilins in pathogenic Proteobacteria Neisseria species (with PilV and PilX). These modulate Tfp-mediated properties without affecting Tfp biogenesis. ComP plays a prominent role in competence at the level of DNA uptake. Comp is exposed on the surface of Neisseria filaments, and it is this that recognises homotypic DNA through genus-specific DNA uptake sequence (DUS) motifs.
Statistics
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PSSM-Id: 522531
Aligned: 84 rows
Threshold Bit Score: 36.1441
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4NOA_A          7 IRSNR-TEGQALLSDAAARQERYYSQNPGVg----------YTKDVAKLGxSSANSPNNLYNLTI----ATPTSTTYTLT 71  Pseudomonas ae...
Q5NI59         35 LRNHR-TEATSELLSAASAADNYEIRFGSF-----------PSGSNIDSF-YHTNTQNSYYSLAYcsgeHQCPNVSYVIT 101 Francisella tu...
WP_015879989   36 RESRR-SEARSELSHIAGLQEQFFLQTQRYas-------lsDLGLSTAAD-NSYLTENGYYRITV----AVSASA-FLLT 101 Tolumonas auensis
ABM04942       39 RTANR-TAAQLALTKIAQEFERTSARQGGYpt--------aLTVPTDTAV-IAAVDSPDVYTITPspvpSERSSSTFKLF 108
Q5F6V4         36 RRARL-SEVKSTLLMNAQNLERYYRQKGTF----------------EKYD-STKLKQNKYFKITL----IKASPDHFTLQ 93  Neisseria gono...
ESQ13026       35 AKARR-AKMQAELTTLAQFMERIYTESGCYnpgedgdcsgaNSDAAEPDI-SAIDDASNHYDIDFv---GDVSADSFLLQ 109
WP_013235593   48 LKARR-AEGRAALLQVLLQQERQFAYQQRYqafep-aqgvpGESDDFKWY-SGGTPQTSAYALSAracdGASLDSCVLVT 124 Herbaspirillum...
CAL62505       37 LKARR-SEGRAALMKGMQQQERYYSLHTTYlafss--astdaEAKKFSWF-SGANAKASFYEISAqacsGKTIRDCVVLI 112
tigr:CJA_3210  43 LKTNRmSEAVPELTSLSQRLQRCYTAYGRFndd------scAVYKELDLG-GYVTPGKGYYEISI----SNVSPTAYTLT 111
WP_012031206   37 LRGYR-VDARNVLMSVAQKLEQNYSISHKYnqmsngdpidnALLNKWGLD-VSPATGTKRYDITL----SEIEEDKFTVK 110 Dichelobacter ...
4NOA_A         72 ATPI---------------NSQT--RDKt------CGKLT 88  Pseudomonas aeruginosa PAO1
Q5NI59        102 ATAQ---------------GTQT--ADTp------CANIE 118 Francisella tularensis subsp. tularensis
WP_015879989  102 AMAA---------------GSQS--SDLd------CLMFS 118 Tolumonas auensis
ABM04942      109 ATPI---------------TGFV--NDGd-----eCGEMT 126
Q5F6V4         94 AAPDtatnegetctvtlndGGTI----AasgtnqsCPGFD 129 Neisseria gonorrhoeae FA 1090
ESQ13026      110 AIPV---------------SGTGqaDD---------GLLQ 125
WP_013235593  125 ATPGg-------------pGVHA--GFSds----aCGRLH 145 Herbaspirillum seropedicae
CAL62505      113 AQPG---------------TGKV--NASyrd--pvCGALS 133
tigr:CJA_3210 112 ATAI---------------LSQA--EDTen----gCNELK 130
WP_012031206  111 ATAF---------------GSQA--SDE-------CKEFT 126 Dichelobacter nodosus
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